Here is Nutrition Solution Calcium Manufacturer talking about animal drugs.
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Ivermectin is a member of the macrocyclic lactone class of endectocides that have a unique mode of action. Compounds of this course bind selectively and with high affinity for glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This also leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the muscle or nerve cell, leading to paralysis and death of the parasite. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA)
The margin of safety for chemicals of this class is attributable to the fact that mammals do not have glutamate-gated gas channels, the macrocyclic lactones have a low affinity for additional bronchial ligand-gated chloride channels and they don't readily cross the adrenal barrier.
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