NSAIDs are the most commonly used pain relievers for horses. These medications work by reducing inflammation, which is often the source of pain. The most widely used NSAID for horses is phenylbutazone, often called “bute.” Others include flunixin meglumine (Banamine) and firocoxib (Equioxx). While effective, it's essential to use these medications under veterinary guidance, as they can have side effects, particularly with long-term use.