Lumpy Skin Disease (LSD) is a highly contagious viral infection that primarily affects cattle. Caused by the Lumpy Skin Disease Virus (LSDV), a member of the Capripoxvirus genus, this disease has been a growing concern in various regions, particularly in Africa, the Middle East, and parts of Asia. The disease not only poses a threat to livestock health but also impacts the agricultural economy, trade, and food security.