The clinical manifestation of Lumpy Skin Disease typically begins with fever, which may reach up to 41°C (105.8°F). Following the rise in body temperature, farmers may notice the development of firm, round nodules on the skin, which can vary in size from a few centimeters to several inches. These nodules can appear across various parts of the body, including the head, neck, and limbs, creating discomfort and pain for the affected animal. Other symptoms may include excessive salivation, nasal discharge, and decreased appetite, leading to weight loss and reduced milk production.