Albendazole Anthelmintic Tablets has high fat solubility and is easier to absorb from the digestive tract than other drugs. Due to the strong first-pass effect, the prototype drug in the blood is rarely or cannot be detected, mainly metabolized to the albendazole sulfoxide in the liver. With metabolites such as sulfone, sulfoxide has anti-helminth activity. After oral administration of albendazole, the half-lives of sulfoxide metabolism in cattle, sheep, pigs, chickens and rabbits were 20.5, 7.7-9, 5.9, 4.3 and 4.1 h, respectively. The half-lives of sulfone metabolites in these animals were 11.6 and 11.8, respectively. , 9.2, 2.5 and 9.6h, showing significant species differences. In addition to sulfoxides and sulfones, there are hydroxylation, hydrolysis and binding products that are excreted viabile.
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