Albendazole Tablet

Albendazole is a benzimidazole with broad-spectrum deworming effect. Nematode is sensitive to it, and it also has a strong effect on tapeworm and fluke (but it needs a larger dose), but it is ineffective against schistosomiasis. The mechanism of action is mainly the combination with tubulin of nematodes. After albendazole is combined with β-tubulin, it is prevented from polymerizing with α-tubulin to assemble microtubules.

Microtubules are the basic structural units of many organelles, which are necessary for cell reproduction processes such as mitosis, protein assembly and energy metabolism. The affinity of albendazole to tubulin of nematodes is significantly higher than that of mammals, so it has little toxicity to mammals. This product has a strong effect not only on adults, but also on immature worms and larvae, as well as killing eggs.

Albendazole is a benzimidazole that is better absorbed orally. Cattle can absorb 50% of the administered dose from the gastrointestinal tract. 47% of the oral dose of the drug metabolite can be recovered from the urine within 9 days. After oral administration in sheep, because it was quickly metabolized to albendazole sulfoxide (the main active metabolite for deworming), the original drug could not be detected in the blood or could only be detected for a short time. 20 hours after the administration, the metabolites albendazole sulfoxide and albendazole sulfone reached peak plasma drug concentrations.

The half-life of sulfoxide metabolites in cattle, sheep, pigs, rabbits, and chickens were 20.5 hours, 7.7-9.0 hours, 5.9hours, 4.1hours, and 4.3hours, respectively. The half lives of the sulfone metabolites were 11.6 hours, 11.8 hours, 9.2 hours, 9.6 hours, and 2.5 hours, respectively. In addition to sulfoxide and sulfone, there are also hydroxylated, hydrolyzed and bound products, which are excreted through the bile.

Dosage And Administration:For oral administration.
Horses and pigs: 5-10mg/kg body weight, i.e. 1 tablet/15-30kg body weight.
Cattle goats and sheep: 10-15mg/kg body weight, i.e. 1 tablet/10-15kg body weight.
Dogs: 25-50mg/kg body weight, i.e. 1 tablet/3-6kg body weight.
Poultry: 10-20mg/kg body weight, i.e. 1 tablet/7.5-15kg body weight.

Adverse Reaction:Dogs with 50mg/kg dosage, twice a day, will gradually produce anorexia. Early pregnancy using albendazole, may be accompanied by embryo toxicity and teratogenic effects.Special Warnings:Do not use in lactating dairy cattle. Pregnancy caution: Do not use during first 45 days of pregnancy for cattle, sheep and goats.

Withdrawal Period
Cattle: 14 days.
Sheep, goats and poultry: 4 days.
Pigs: 7 days.
Milk: 60 hours.

Storage:Seal and store in room temperature.
Keep out of reach of children.
Packaging:5 tablets/blister/box
Shelf Life:3 years.