Amoxicillin Injection

Amoxicillin is a broad-spectrum antibiotic of the amino-penicillin family with close structural relationship to ampicillin.
Amoxicillin is a bactericide and is active against Gram-positive and Gram-negative bacteria. It inhibits the synthesis and reparation of the bacterial mucopeptide cell wall.
Amoxicillin is a semisynthetic penicillin and susceptible to the action of bacterial beta-lactamases.
Amoxicillin is a time-dependent antibiotic.
Amoxicillin is active against the following microorganisms which are involved in respiratory diseases in cattle: Mannheimia haemolytica and Pasteurella multocida. Amoxicillin is also active against Pasteurella multocida that is involved in respiratory diseases in pig.

In cattle Cmax (3.45 µg/ml) is reached 2.45 hours after intramuscular administration. In pigs Cmax (3.54 µg/ml) is reached 2 hours after intramuscular administration.
Amoxicillin is mainly distributed to the extra-cellular compartment. Its distribution into tissues is facilitated by its low degree of plasma protein binding (17%). Concentrations in pulmonary, pleural and bronchial tissues are similar to plasma concentrations. Amoxicillin diffuses into pleural and synovial fluid and into lymphatic tissue.
Amoxicillin is biotransformed in the liver by hydrolysis of the ß-lactam ring leading to inactive penicilloic acid (20%).
Amoxicillin is mainly excreted in active form via the kidneys, and secondarily by the biliary route and through milk.

Adverse Reaction:As with all penicillins, amoxicillin may cause hypersensitivity (allergy) and should not be used when an animal is known to be allergic to beta-lactams. Occasional local reaction of a transient nature may occur at the site of injection.
Special Warnings:Shake well before use. Milk for human consumption must not be taken during treatment. Milk for human consumption may be taken only from cattle after 96 hours from the last treatment.

Withdrawal Period
Cattle and pigs: 28 days.
Milk: 4 hours.

Storage:Seal and protect from light.
Keep out of reach of children.
Packaging:100ml/bottle.
Shelf Life:3 years.