Diminazene Granules

COMPOSITION

Each sachet 2.36g contains Diminazene aceturate 1.05g and Antipyrine 1.31g.

INDICAITON

It is a very effective and well tolerated drug used for the treatment and control of Typanosomiasis, Babesiosis and Theileriosis in animals.


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Pharmacodynamic Properties

Antipyrine is an analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver.

 

Pharmacokinetic Properties

The pharmacokinetics of diminazene have been investigated in the laboratory and target animal species. In general, the peak blood levels (Cmax) were reached within 1 hour after dosing. The only exception was the dog, in which peak levels were not reacheduntil 3 hours after dosing. The peak blood levels were 1.1 ppm in the rabbit, 13 ppm in the rat,4.6 to 6 ppm in cattle and 3.9 to 6.7 in goats and sheep.


The elimination from the blood was generally biphasic, with a half-life of approximately 1.3 hours for the initial phase and up to 188 hours for the terminal phase. However, the studies by Aliu and Odegaard indicated that the sheep displayed a triphasic elimination curve which is indicative of a three-compartment model. In cattle, the drugwas primarily excreted in the urine. More than seven times as muchradioactivity was found in the urine than in the feces in this species. By day 20 after dosing, more than 80 of the dose had been eliminated.

 

 

Dosage And Administration:By intramuscular injection.
3.5 mg active ingredient / kg bodyweight.
Do not exceed a total dose of 4g active ingredient in any animal.
Dissolve the whole content of the sachet in 12.5ml of water for injection.
Inject 15ml of reconstituted solution for 300Kg of body weight.


Adverse Reaction:Dininazene has larger toxicity, can cause parasympathetic excited response. Excessive use can cause death. The product has a strong local tissue irritation.


Withdrawal Period:Meat: 28days.
Milk: 7days.


Storage:eal and protect from light.
The ready solution can be stored 24 hours, protected from light and in a closed sterile glass bottle.
Packaging:2.36g/sachet, 10sacets/box.
Shelf Life:3 years.

 

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