Doramectin Injection

COMPOSITION

Each ml contains Doramectin 31.5mg.

INDICAITON

Antiparasitic drugs. For the treatment of nematode diseases, blood stasis, rickets and other ectoparasites.

 


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Pharmacodynamic Properties

Doramectin is an antiparasitic agent, isolated from fermentation of selected strains derived from the soil organism Streptomyces avermitilis. It is a macrocyclic lactone and is closely related to ivermectin. Both compounds share a wide spectrum of antiparasitic activity and produce a similar paralysis in nematodes and parasitic arthropods. Macrocyclic lactones activate glutamate gated chloride channels (GluCl) found on muscle membranes of the pharynx and particular neurones of invertebrate parasites. The selective toxicity of the macrocyclic lactones as antiparasitics is attributed to this action on channels that are not present in the host animal. There is evidence that the membranes of the muscle cells of the invertebrate female reproductive tract may be more sensitive to macrocyclic lactones than receptors on nerve or other muscle and this may explain the dramatic but temporary reduction in egg production in parasites not killed or eliminated by drug therapy.

 

Pharmacokinetic Properties

Maximum plasma concentration of doramectin occurs in pigs 3 days after intramuscular administration of the product. The elimination half-life is around six days.

 

Dosage And Administration:For subcutaneous or intramuscular injection.
Cattle and sheep: 0.2-0.3mg/kg body weight, i.e. 1ml/105- 160kg body weight.
Pigs: 0.3mg/kg body weight, i.e. 1ml/105kg body weight.

 

Adverse Reaction:No adverse reaction according to the recommend dosage.
Special Warnings:Do not smoke or eat while handling the product. Wash hands after use. Extremely dangerous for fish and aquatic life. Do not contaminate ponds, waterways or ditches with the product or used container.

 

Withdrawal Period:Pigs: 28 days.
Cattle and sheep: 35 days.

 

Storage:Seal and protect from light.
Keep out of reach of children.
Packaging:100ml/bottle
Shelf Life:3 years.

 

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