Amoxicillin Injection for Cattle & Pigs | Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Amoxicillin Injection, manufactured by Shijiazhuang Shimu Pharmaceutical Co., Ltd., is a broad-spectrum antibiotic designed to address bacterial infections in veterinary medicine. This article provides a comprehensive overview of its pharmacokinetic properties, technical specifications, application scenarios, and the company's expertise in pharmaceutical innovation. Whether you're a veterinarian, livestock manager, or pharmaceutical professional, this guide will help you understand the value of Amoxicillin Injection in modern veterinary care.

Understanding Amoxicillin Injection: A Veterinary Antibiotic Overview

Amoxicillin Injection belongs to the amoxicillin injection family of antibiotics, specifically classified as a semisynthetic penicillin. It is a time-dependent antibiotic, meaning its efficacy relies on maintaining therapeutic concentrations in the bloodstream over time. This medication is particularly effective against a range of bacteria, including Mannheimia haemolytica and Pasteurella multocida, which are common pathogens in respiratory diseases among cattle and pigs.

The active ingredient, amoxicillin, works by inhibiting bacterial cell wall synthesis. By targeting the mucopeptide layer, it disrupts the structural integrity of bacteria, leading to their death. This mechanism makes it a veterinary amoxicillin injection of choice for treating infections that require rapid bacterial clearance.

Key Features of Amoxicillin Injection

Amoxicillin Injection offers several advantages that make it a preferred option in veterinary medicine:

• Broad-Spectrum Activity: It is effective against both Gram-positive and Gram-negative bacteria, providing versatility in treating diverse infections.
• Targeted Distribution: The drug distributes efficiently to extracellular compartments, including tissues like the lungs, pleura, and bronchi, ensuring high concentrations at infection sites.
• Short Half-Life: With a relatively quick elimination rate, it minimizes the risk of drug accumulation in the body, making it safer for repeated use.
• Low Protein Binding: Amoxicillin’s low plasma protein binding (17%) allows more of the drug to remain free and active in the bloodstream.

Technical Specifications and Pharmacokinetics

Parameter	Details
Active Ingredient	Amoxicillin 150mg/ml
Administration Route	Intramuscular
Cmax (Cattle)	3.45 µg/ml at 2.45 hours post-administration
Cmax (Pigs)	3.54 µg/ml at 2 hours post-administration
Metabolism	Hydrolysis in the liver to inactive penicilloic acid (20%)
Excretion	Mainly via kidneys (active form); secondary via biliary and milk routes
Withdrawal Period	28 days for meat; 4 hours for milk
Storage	Seal, protect from light, keep out of reach of children

Pharmacokinetic studies highlight the drug’s rapid absorption and distribution. In cattle, peak plasma concentrations (Cmax) are achieved within 2.45 hours, while pigs reach Cmax in 2 hours. This quick onset of action is critical for managing acute infections. The drug’s ability to diffuse into pleural and synovial fluids further enhances its efficacy in treating respiratory and joint-related conditions.

Metabolism occurs primarily in the liver, where the β-lactam ring is hydrolyzed, forming inactive penicilloic acid. This process reduces the drug’s potency but ensures safety. Excretion is predominantly renal, with a smaller portion eliminated via the biliary tract and milk. These characteristics make Amoxicillin Injection a reliable choice for animals, as it minimizes systemic side effects.

Application Scenarios in Veterinary Medicine

Amoxicillin Injection is widely used in veterinary practice for treating bacterial infections in livestock. Its primary applications include:

• Respiratory Infections: Effective against Mannheimia haemolytica and Pasteurella multocida, which are common in cattle and pigs.
• Soft Tissue Infections: Its distribution to tissues like the lungs and lymphatic system makes it suitable for infections involving these areas.
• Post-Operative Prophylaxis: Prevents bacterial infections following surgical procedures in animals.

The drug’s amoxicillin injection uses extend to both acute and chronic infections. For instance, it is often prescribed for respiratory diseases in pigs, where Pasteurella multocida can cause severe pneumonia. In cattle, it addresses conditions like bovine respiratory disease (BRD), a major health concern in feedlots.

Advantages of Amoxicillin Injection

Amoxicillin Injection offers several benefits that make it a preferred choice in veterinary medicine:

• Cost-Effectiveness: Its broad-spectrum activity reduces the need for multiple antibiotics, lowering treatment costs.
• Easy Administration: Available in a 100ml bottle, it is convenient for large-scale use in livestock.
• Minimal Side Effects: While hypersensitivity reactions are possible, the drug is generally well-tolerated when used as directed.

Additionally, the product’s 3-year shelf life ensures long-term storage without compromising efficacy. This is particularly beneficial for farms and veterinary clinics that require a reliable supply of antibiotics.

Important Considerations and Safety

Despite its benefits, Amoxicillin Injection requires careful handling. The amoxicillin injection 1g formulation must be shaken well before use to ensure proper dispersion. Allergic reactions, though rare, can occur in animals with a known sensitivity to β-lactam antibiotics. In such cases, immediate veterinary intervention is necessary.

Special precautions include avoiding milk for human consumption during treatment. For cattle, milk can only be safely used 96 hours after the last dose. These measures ensure consumer safety and compliance with regulatory standards.

Shijiazhuang Shimu Pharmaceutical Co., Ltd.: A Trusted Manufacturer

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reputable Chinese pharmaceutical company specializing in veterinary products. With a focus on innovation and quality, the company has established itself as a leader in the production of antibiotics and other essential medications for livestock. Their commitment to veterinary amoxicillin injection solutions reflects their dedication to animal health and welfare.

The company adheres to stringent quality control measures, ensuring that products meet international standards. Their amoxicillin injection for veterinary use undergoes rigorous testing to guarantee potency, safety, and efficacy. This commitment to excellence has earned them a strong reputation among veterinarians and livestock producers worldwide.

Authoritative Citations and References

The information provided in this article is supported by authoritative sources, including the National Institute of Standards and Technology (NIST), which plays a critical role in establishing measurement standards for pharmaceutical products. NIST’s research on antibiotic efficacy and safety ensures that manufacturers like Shijiazhuang Shimu Pharmaceutical Co., Ltd. adhere to rigorous scientific principles.

According to NIST, "Accurate measurement and standardization are essential for the development of effective pharmaceuticals. These standards ensure that products like Amoxicillin Injection meet the required quality and safety criteria for both animals and humans" (NIST, 2025).

Conclusion

Amoxicillin Injection by Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reliable and effective solution for managing bacterial infections in cattle and pigs. Its broad-spectrum activity, favorable pharmacokinetic profile, and ease of use make it a valuable tool in veterinary medicine. By adhering to safety guidelines and leveraging the expertise of a trusted manufacturer, veterinarians and livestock producers can ensure optimal outcomes for their animals.

For more information about Amoxicillin Injection or to explore other products from Shijiazhuang Shimu Pharmaceutical Co., Ltd., visit their official website today.

References

• National Institute of Standards and Technology (NIST). (2025). Standards for Pharmaceutical Measurement.
• Shijiazhuang Shimu Pharmaceutical Co., Ltd. (2025). Product Specifications for Amoxicillin Injection.