Amoxicillin Injection for Veterinary Use - Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Amoxicillin Injection is a critical solution in veterinary medicine, designed to combat bacterial infections in livestock such as cattle and pigs. Developed by Shijiazhuang Shimu Pharmaceutical Co., Ltd., a reputable veterinary pharmaceutical company, this product combines efficacy with safety to address common respiratory diseases. This article provides a comprehensive overview of its pharmacokinetic properties, application scenarios, technical specifications, and company background, supported by authoritative references.

Understanding Amoxicillin Injection

Amoxicillin Injection belongs to the amino-penicillin family, closely related to ampicillin. It acts as a bactericide, targeting both Gram-positive and Gram-negative bacteria by inhibiting the synthesis of bacterial cell walls. This semisynthetic penicillin is particularly effective against Mannheimia haemolytica and Pasteurella multocida, which are major pathogens in respiratory diseases among cattle and pigs. For more details, visit the product page.

Pharmacokinetic Properties

Understanding how Amoxicillin Injection is absorbed, distributed, metabolized, and excreted is essential for its effective use. Key findings include:

• Peak Concentration (Cmax): In cattle, Cmax reaches 3.45 µg/ml within 2.45 hours after intramuscular administration. In pigs, it reaches 3.54 µg/ml in 2 hours.
• Distribution: The drug distributes to the extracellular compartment with low plasma protein binding (17%), allowing it to penetrate tissues like the lungs, pleura, and bronchial tissues. It also diffuses into pleural and synovial fluids and lymphatic tissue.
• Metabolism: In the liver, amoxicillin undergoes hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20%).
• Excretion: The majority is excreted via the kidneys in active form, with secondary excretion through the biliary route and milk.

Application Scenarios

Amoxicillin Injection is primarily used to treat bacterial infections in livestock, particularly those caused by Mannheimia haemolytica and Pasteurella multocida. These pathogens are responsible for respiratory diseases in cattle and pigs, leading to significant economic losses in the agricultural sector. The product’s broad-spectrum activity and rapid absorption make it ideal for acute infections in these animals.

Adverse Reactions and Warnings

As with all penicillins, Amoxicillin Injection may cause hypersensitivity reactions. It should not be used in animals with a known allergy to β-lactams. Local reactions at the injection site are rare but may occur. Additionally, milk from treated animals must not be used for human consumption during treatment. For cattle, milk can be safely consumed 96 hours post-treatment.

Withdrawal Periods

Adhering to withdrawal periods is crucial to ensure food safety:

• Cattle and Pigs: 28 days after the last dose.
• Milk: 4 hours after administration.

Storage and Packaging

Amoxicillin Injection should be stored in a sealed container111, protected from light, and kept out of reach of children. The product is available in 100ml bottles with a shelf life of 3 years.

Product Specifications Table

Parameter	Details
Active Ingredient	Amoxicillin 150mg/ml
Indication	Treatment of bacterial infections caused by Gram-positive and Gram-negative bacteria
Administration Route	Intramuscular
Cmax in Cattle	3.45 µg/ml at 2.45 hours
Cmax in Pigs	3.54 µg/ml at 2 hours
Metabolism	Hydrolysis in the liver to inactive penicilloic acid (20%)
Excretion	Mainly via kidneys, with secondary excretion through biliary route and milk
Withdrawal Period (Milk)	4 hours
Storage Conditions	Sealed, protected from light, out of reach of children
Packaging	100ml/bottle
Shelf Life	3 years

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading veterinary pharmaceutical company specializing in antibiotic formulations for livestock. With a focus on research and development, the company ensures its products meet international quality standards. Their commitment to animal health and food safety is reflected in the Amoxicillin Injection, which balances efficacy and safety for cattle and pigs. Learn more about their mission at Shijiazhuang Shimu Pharmaceutical Co., Ltd..

Authoritative Citations and References

According to the National Institute of Standards and Technology (NIST), the accuracy of pharmaceutical measurements is critical for ensuring drug efficacy and safety. NIST’s work on standardized testing protocols for antibiotics supports the development of reliable veterinary products like Amoxicillin Injection. For further details, refer to the NIST guidelines on pharmaceutical standards.

Conclusion

Amoxicillin Injection by Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a vital tool in veterinary medicine, offering a broad-spectrum solution for respiratory infections in cattle and pigs. Its favorable pharmacokinetic profile, easy administration, and strict safety protocols make it a trusted choice for livestock health management. For more information, explore the product page or contact the company directly.

References

National Institute of Standards and Technology (NIST). (n.d.). Pharmaceutical Measurement Standards. Retrieved from https://www.nist.gov