Amoxicillin Injection for Veterinary Use-Shijiazhuang Shimu Pharmaceutical Co., Ltd.|Broad-Spectrum Antibiotic&Effective Bacterial Treatment

Amoxicillin injection, a critical component in veterinary medicine, is a broad-spectrum antibiotic derived from the amino-penicillin family. This article provides an in-depth analysis of its pharmacokinetic properties, therapeutic applications, and the company behind its production, Shijiazhuang Shimu Pharmaceutical Co., Ltd.. The information is structured to offer a detailed understanding of this medication's efficacy, safety, and relevance in treating bacterial infections in livestock.

Pharmacokinetic Properties of Amoxicillin Injection

Amoxicillin is a bactericidal antibiotic that demonstrates activity against both Gram-positive and Gram-negative bacteria. Its mechanism of action involves inhibiting the synthesis and repair of bacterial mucopeptide cell walls, making it an effective treatment for various infections. As a time-dependent antibiotic, its efficacy is closely related to the duration of exposure to the pathogen rather than peak concentration.

Key Pharmacokinetic Data

• Cattle: Maximum plasma concentration (Cmax) of 3.45 µg/ml is achieved 2.45 hours after intramuscular administration.
• Pigs: Cmax of 3.54 µg/ml is reached 2 hours post-injection.
• Distribution: Amoxicillin predominantly distributes to the extracellular compartment with low plasma protein binding (17%). It reaches similar concentrations in pulmonary, pleural, and bronchial tissues as in plasma, diffusing into pleural, synovial, and lymphatic tissues.
• Metabolism: The drug is biotransformed in the liver via hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20%).
• Excretion: Primarily eliminated via the kidneys in its active form, with secondary excretion through the biliary route and milk.

Read More About amoxicillin injection uses

Therapeutic Applications in Veterinary Medicine

Amoxicillin injection is specifically indicated for treating infections caused by susceptible bacteria in cattle and pigs. Its efficacy against Mannheimia haemolytica and Pasteurella multocida makes it a vital tool in managing respiratory diseases in livestock. These pathogens are commonly associated with bovine and porcine respiratory conditions, necessitating targeted antibiotic therapy.

The drug's broad-spectrum activity extends to other Gram-positive and Gram-negative bacteria, providing a versatile solution for various bacterial infections. However, its use must be carefully managed to mitigate the risk of resistance development and ensure optimal therapeutic outcomes.

Adverse Reactions and Safety Considerations

As with all β-lactam antibiotics, amoxicillin may cause hypersensitivity reactions in animals. It should not be administered to animals with a known allergy to penicillins. Local reactions at the injection site, such as swelling or redness, may occur but are typically transient.

Important Warnings:

• Shake the vial well before use to ensure uniform distribution of the active ingredient.
• Milk from treated animals must not be used for human consumption during treatment. For cattle, milk can be safely harvested 96 hours after the last dose.

Withdrawal Periods and Storage Guidelines

Proper adherence to withdrawal periods is crucial to ensure the safety of animal products for human consumption. The withdrawal periods for amoxicillin injection are as follows:

• Cattle and Pigs: 28 days
• Milk: 4 hours

Storage Instructions: Store the product in a sealed container111, protected from light, and keep it out of reach of children. The recommended packaging is 100ml/bottle with a shelf life of 3 years.

Product Specifications Table

Parameter	Details
Active Ingredient	Amoxicillin 150mg/ml
Indication	Treatment of bacterial infections caused by Gram-positive and Gram-negative bacteria
Administration Route	Intramuscular
Pharmacokinetic Profile	Cmax in cattle: 3.45 µg/ml (2.45h); Cmax in pigs: 3.54 µg/ml (2h)
Metabolism	Hydrolysis in the liver to form penicilloic acid
Excretion	Renal (primary), biliary (secondary), and milk (secondary)
Withdrawal Period	Cattle/Pigs: 28 days; Milk: 4 hours
Storage	Sealed, light-protected, out of reach of children
Shelf Life	3 years

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reputable manufacturer of veterinary pharmaceuticals, specializing in the production of high-quality antibiotics and related products. With a commitment to scientific innovation and rigorous quality control, the company ensures that its products meet international standards for efficacy and safety.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is dedicated to addressing the challenges of animal health through advanced research and development. Their product portfolio includes a range of antibiotics, including amoxicillin injection, designed to support the health and productivity of livestock while adhering to regulatory guidelines.

Expert Insights and Industry Standards

The development and application of antibiotics like amoxicillin are guided by principles of antimicrobial stewardship, which emphasize the responsible use of these critical medications. According to the National Institute of Standards and Technology (NIST), rigorous testing and standardization are essential to ensure the accuracy and reliability of pharmaceutical products. NIST's role in advancing measurement science and technical standards contributes to the global effort to maintain drug quality and safety.

As highlighted by NIST, "Precision in measurements is foundational to the development of effective pharmaceuticals, ensuring that each dose delivers the intended therapeutic benefit while minimizing risks" (NIST, 2025).

Conclusion

Amoxicillin injection remains a cornerstone in the treatment of bacterial infections in veterinary medicine, offering a balance of efficacy, safety, and practicality. Its pharmacokinetic profile, coupled with the expertise of manufacturers like Shijiazhuang Shimu Pharmaceutical Co., Ltd., ensures that it meets the needs of both practitioners and livestock. By adhering to established guidelines and leveraging scientific advancements, the veterinary pharmaceutical industry continues to enhance animal health and welfare.

References

NIST (National Institute of Standards and Technology). (2025). https://www.nist.gov

Shijiazhuang Shimu Pharmaceutical Co., Ltd.. (n.d.). https://www.skyvetpharm.com