Amoxicillin Injection - Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Amoxicillin Injection is a critical veterinary medication designed to combat bacterial infections in livestock, particularly in cattle and pigs. Manufactured by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this antibiotic is a cornerstone in veterinary medicine due to its broad-spectrum efficacy and favorable pharmacokinetic profile. This article explores the core features, technical specifications, application scenarios, and company background of this essential product.

Product Overview

Amoxicillin Injection is a semisynthetic penicillin derived from ampicillin, offering potent activity against both Gram-positive and Gram-negative bacteria. Its primary mechanism involves inhibiting bacterial cell wall synthesis by targeting the mucopeptide layer, making it a bactericidal agent. The product is specifically formulated for intramuscular administration, ensuring rapid systemic absorption and therapeutic effectiveness.

Key Features

• Broad-Spectrum Activity: Effective against pathogens like Mannheimia haemolytica and Pasteurella multocida, which are common in respiratory infections of cattle and pigs.
• Time-Dependent Antibiotic: Requires sustained plasma concentrations for optimal efficacy.
• Low Plasma Protein Binding: 17% binding, allowing for efficient distribution to extracellular compartments.
• Short Withdrawal Period: 28 days for meat and 4 hours for milk, ensuring compliance with food safety regulations.

Technical Specifications

Parameter	Value
Active Ingredient	Amoxicillin 150mg/ml
Administration Route	Intramuscular
Peak Plasma Concentration (Cmax)	Cattle: 3.45 µg/ml (2.45 hours post-administration); Pigs: 3.54 µg/ml (2 hours post-administration)
Half-Life	Approximately 1-2 hours (varies by species)
Excretion Pathways	Renal (main), biliary, and milk
Storage Conditions	Sealed, protected from light, and out of reach of children
Shelf Life	3 years

Pharmacokinetic Properties

Amoxicillin Injection demonstrates rapid absorption and distribution in target tissues. After intramuscular administration, the drug reaches peak plasma concentrations within 2-2.5 hours. Its low plasma protein binding (17%) facilitates diffusion into pulmonary, pleural, and bronchial tissues, where it effectively targets respiratory pathogens. The drug is primarily metabolized in the liver via β-lactamase hydrolysis, forming inactive penicilloic acid. Excretion occurs predominantly through the kidneys, with secondary routes including the biliary system and milk.

Application Scenarios

This antibiotic is widely used in veterinary medicine to treat infections caused by susceptible bacteria. Key applications include:

• Respiratory Infections: Targeting Mannheimia haemolytica and Pasteurella multocida in cattle and pigs.
• Systemic Infections: Addressing bacterial spread in tissues and organs.
• Post-Operative Prophylaxis: Preventing infections following surgical procedures.

For detailed usage guidelines, visit the Amoxicillin Injection Product Page.

Advantages

Shijiazhuang Shimu Pharmaceutical Co., Ltd. prioritizes quality and efficacy in its formulations. The advantages of this product include:

• High Bioavailability: Ensures rapid therapeutic action post-administration.
• Compliance with Regulatory Standards: Meets stringent veterinary drug safety and efficacy requirements.
• Cost-Effective: Provides value for livestock producers managing bacterial infections.
• Easy Handling: Simple storage and administration protocols.

Adverse Reactions and Warnings

As with all β-lactam antibiotics, Amoxicillin Injection carries risks of hypersensitivity reactions. Animals with known allergies to penicillins should not receive this medication. Common side effects include transient local reactions at the injection site. Additionally, milk from treated animals must be discarded for 4 hours post-treatment, and meat withdrawal periods are 28 days to ensure safety for human consumption.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals based in China. With a focus on innovation and quality, the company develops products that meet international standards. Their commitment to animal health and food safety positions them as a trusted partner for livestock producers worldwide.

For more information about the company, visit the Shijiazhuang Shimu Pharmaceutical Co., Ltd. Website.

Authoritative Citations

While the context does not directly reference NIST (National Institute of Standards and Technology) for this product, the principles of pharmaceutical quality control and regulatory compliance align with NIST's role in ensuring measurement accuracy and standards. For further insights into antibiotic efficacy and safety, consult NIST's research on analytical chemistry and biomedical measurements:

• NIST Official Website
• NIST Chemistry Division

Conclusion

Amoxicillin Injection by Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a vital tool in managing bacterial infections in cattle and pigs. Its broad-spectrum activity, favorable pharmacokinetics, and compliance with safety standards make it a preferred choice for veterinary professionals. By understanding its technical specifications and application scenarios, livestock producers can optimize treatment outcomes while ensuring food safety.

For detailed product information, visit the Amoxicillin Injection Product Page.