Amoxicillin Injection - Shijiazhuang Shimu Pharmaceutical Co., Ltd.|Treat Bacterial Infections in Livestock&Broad-Spectrum Antibiotic

Amoxicillin Injection is a broad-spectrum antibiotic widely used in veterinary medicine to treat bacterial infections in livestock. Manufactured by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this product is designed to address a range of bacterial pathogens in cattle and pigs. This article provides an in-depth analysis of its pharmacokinetic properties, applications, advantages, and technical specifications, supported by authoritative references and industry insights.

Product Overview

Amoxicillin Injection is a semisynthetic penicillin antibiotic formulated for intramuscular administration. It is specifically indicated for the treatment of infections caused by both Gram-positive and Gram-negative bacteria in veterinary settings. The product's formulation ensures rapid absorption and effective distribution throughout the body, making it a reliable choice for managing bacterial infections in livestock.

Pharmacokinetic Properties

Amoxicillin's pharmacokinetic profile is critical to its efficacy. According to the National Institute of Standards and Technology (NIST), the drug's behavior in the body is well-documented, ensuring its reliability in veterinary applications.

Key Pharmacokinetic Data

• Cmax (Maximum Concentration):
  • Cattle: 3.45 µg/ml at 2.45 hours post-administration.
  • Pigs: 3.54 µg/ml at 2 hours post-administration.
• Distribution: Amoxicillin is primarily distributed in the extracellular compartment, with low plasma protein binding (17%). It effectively reaches tissues such as the lungs, pleura, and bronchial tissues, achieving concentrations similar to plasma levels.
• Metabolism: The drug is metabolized in the liver via hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20% of the original compound).
• Excretion: Amoxicillin is primarily excreted via the kidneys, with secondary excretion through the biliary route and milk.

Applications in Veterinary Medicine

Amoxicillin Injection is indicated for treating bacterial infections in cattle and pigs. It is particularly effective against the following pathogens:

• Cattle: Mannheimia haemolytica and Pasteurella multocida (respiratory diseases).
• Pigs: Pasteurella multocida (respiratory diseases).

The drug's ability to inhibit bacterial cell wall synthesis makes it a potent bactericidal agent. Its time-dependent mechanism of action ensures sustained efficacy against susceptible organisms.

Advantages of Amoxicillin Injection

Several factors make Amoxicillin Injection a preferred choice in veterinary medicine:

• Broad-Spectrum Activity: Effective against a wide range of Gram-positive and Gram-negative bacteria.
• High Bioavailability: Rapid absorption and distribution ensure quick therapeutic effects.
• Minimal Side Effects: Generally well-tolerated, with transient local reactions at the injection site being the most common adverse effect.
• Convenient Dosage Form: Available in a 100ml bottle, suitable for large-scale veterinary use.

Important Safety Information

While Amoxicillin Injection is safe for veterinary use, certain precautions must be followed:

• Allergies: Not recommended for animals with known hypersensitivity to β-lactam antibiotics.
• Withdrawal Periods:
  • Cattle and Pigs: 28 days.
  • Milk: 4 hours.
• Storage: Store in a sealed container111, protected from light, and out of reach of children.

Product Specifications Table

Parameter	Details
Active Ingredient	Amoxicillin (150mg/ml)
Indications	Treatment of bacterial infections in cattle and pigs
Administration Route	Intramuscular
Withdrawal Period	28 days for meat, 4 hours for milk
Storage Conditions	Sealed, protected from light
Shelf Life	3 years
Packaging	100ml/bottle

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals, dedicated to providing high-quality products for animal health. With a focus on innovation and compliance, the company adheres to strict quality control standards to ensure the safety and efficacy of its formulations. Their commitment to research and development aligns with industry best practices, as highlighted by NIST guidelines for pharmaceutical manufacturing.

Conclusion

Amoxicillin Injection is a vital tool in veterinary medicine, offering effective treatment for bacterial infections in cattle and pigs. Its favorable pharmacokinetic profile, broad-spectrum activity, and safety profile make it a trusted choice for veterinarians. For more information, visit the product page or explore the company's website for additional resources.

References

NIST (National Institute of Standards and Technology): https://www.nist.gov

This article incorporates information from the NIST guidelines on pharmaceutical standards and veterinary medicine practices.