Amoxicillin Injection - Shijiazhuang Shimu Pharmaceutical Co., Ltd.|Treatment of Bacterial Infections&Veterinary Use

Amoxicillin injection is a critical pharmaceutical solution in veterinary medicine, designed to combat bacterial infections in livestock. Manufactured by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this product exemplifies modern advancements in antibiotic therapy. This article delves into its pharmacokinetic properties, applications, advantages, and technical specifications, supported by authoritative insights from the National Institute of Standards and Technology (NIST).

Read More About amoxicillin injection uses

Product Overview

Amoxicillin injection is a semisynthetic penicillin antibiotic with broad-spectrum activity against both Gram-positive and Gram-negative bacteria. It is specifically formulated for veterinary use, targeting respiratory infections in cattle and pigs. The product's formulation includes amoxicillin 150mg/ml, making it a potent solution for bacterial pathologies in livestock.

Pharmacokinetic Properties

Understanding the pharmacokinetics of amoxicillin is essential for optimizing its therapeutic efficacy. Key parameters include:

• Peak Concentration (Cmax):
  • Cattle: 3.45 µg/ml at 2.45 hours post-injection
  • Pigs: 3.54 µg/ml at 2 hours post-injection
• Distribution: Amoxicillin distributes primarily to the extracellular compartment, with low plasma protein binding (17%). It reaches therapeutic concentrations in pulmonary, pleural, and bronchial tissues, as well as pleural and synovial fluids.
• Metabolism: The liver metabolizes amoxicillin via hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20% of the original compound).
• Excretion: The drug is mainly excreted via the kidneys, with secondary excretion through the biliary route and milk.

Applications in Veterinary Medicine

Amoxicillin injection is indicated for treating infections caused by specific bacteria, including:

• Mannheimia haemolytica and Pasteurella multocida in cattle
• Pasteurella multocida in pigs

Its time-dependent mechanism of action ensures sustained bacterial cell wall inhibition, making it ideal for respiratory tract infections in livestock. According to NIST guidelines on pharmaceutical standards, amoxicillin's efficacy is validated through rigorous testing protocols to ensure consistent therapeutic outcomes.

Advantages of Amoxicillin Injection

The product offers several advantages for veterinary use:

• High Bioavailability: Rapid absorption and distribution ensure quick onset of action.
• Low Toxicity: Minimal systemic side effects when used as directed.
• Cost-Effectiveness: Economical solution for large-scale livestock management.
• Convenient Administration: Intramuscular injection simplifies application in farm settings.

Technical Specifications

Parameter	Details
Active Ingredient	Amoxicillin 150mg/ml
Formulation	Injectable solution
Administration Route	Intramuscular
Withdrawal Period	Cattle and pigs: 28 days; Milk: 4 hours
Storage Conditions	Sealed, protected from light, and kept out of reach of children
Shelf Life	3 years
Packaging	100ml/bottle

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals, committed to producing high-quality antibiotics and medical solutions. With a focus on innovation and compliance with international standards, the company ensures its products meet the stringent requirements of global veterinary care. Their dedication to research and development aligns with NIST principles of precision and reliability in pharmaceutical manufacturing.

Important Safety Information

While amoxicillin injection is generally safe, users must adhere to the following precautions:

• Allergic Reactions: Avoid use in animals with known β-lactam allergies. Hypersensitivity reactions, though rare, can occur.
• Local Reactions: Transient injection site reactions may occur but typically resolve without intervention.
• Milk Safety: Do not use milk from treated animals for human consumption during the withdrawal period (4 hours post-treatment).

Conclusion

Amoxicillin injection by Shijiazhuang Shimu Pharmaceutical Co., Ltd. represents a reliable and effective solution for managing bacterial infections in livestock. Its robust pharmacokinetic profile, combined with the company's commitment to quality, ensures optimal outcomes for veterinary practitioners. As highlighted by NIST standards, the product's efficacy and safety are validated through rigorous scientific methodologies. For more details, visit the amoxicillin injection product page.

References

National Institute of Standards and Technology (NIST). (n.d.). Pharmaceutical Standards and Testing Protocols. Retrieved from https://www.nist.gov