Amoxicillin Injection - Shijiazhuang Shimu Pharmaceutical Co., Ltd.|Veterinary Antibiotic & Broad-Spectrum Treatment

Amoxicillin Injection is a broad-spectrum antibiotic widely used in veterinary medicine to treat bacterial infections in livestock. Developed by Shijiazhuang Shimu Pharmaceutical Co., Ltd. (石家庄石牧药业有限公司), this product offers a robust therapeutic option for managing respiratory diseases in cattle and pigs. This article provides an in-depth analysis of its pharmacokinetic properties, technical specifications, applications, and the company's commitment to quality. For more details, visit the product page.

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Product Overview

Amoxicillin Injection is a semisynthetic penicillin derived from ampicillin, designed to combat both Gram-positive and Gram-negative bacteria. Its mechanism of action involves inhibiting bacterial cell wall synthesis, making it effective against pathogens like Mannheimia haemolytica and Pasteurella multocida in cattle and pigs. The product is formulated for intramuscular administration, ensuring rapid absorption and therapeutic efficacy.

Pharmacokinetic Properties

Understanding the pharmacokinetics of amoxicillin injection is critical for optimizing its therapeutic use. Key data include:

• Cmax (Maximum Concentration): 3.45 µg/ml in cattle and 3.54 µg/ml in pigs, achieved within 2.45 and 2 hours post-administration, respectively.
• Distribution: Amoxicillin distributes to extracellular compartments with low plasma protein binding (17%), enabling effective concentrations in tissues like the lungs, pleura, and bronchial tissues.
• Metabolism: Primarily metabolized in the liver via hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20% of the original compound).
• Excretion: Mainly eliminated via the kidneys in its active form, with secondary excretion through the biliary route and milk.

Technical Specifications

Parameter	Details
Active Ingredient	Amoxicillin 150mg/ml
Indication	Treatment of infections caused by Gram-positive and Gram-negative bacteria
Administration Route	Intramuscular
Withdrawal Period	Cattle and pigs: 28 days; Milk: 4 hours
Storage Conditions	Seal, protect from light, and keep out of reach of children
Packaging	100ml/bottle
Shelf Life	3 years

Applications in Veterinary Medicine

Amoxicillin Injection is particularly effective in managing respiratory infections in livestock, where bacterial pathogens like Mannheimia haemolytica and Pasteurella multocida are prevalent. Its broad-spectrum activity and favorable pharmacokinetic profile make it suitable for:

• Treating bovine respiratory disease (BRD) in cattle
• Managing porcine respiratory infections in pigs
• Addressing bacterial infections in other livestock species

For detailed application guidelines, refer to the product documentation.

Advantages of Amoxicillin Injection

The product offers several benefits, including:

• High Efficacy: Rapid bacterial cell wall inhibition ensures quick therapeutic action.
• Low Toxicity: Minimal adverse effects when used as directed, with transient local reactions at the injection site being rare.
• Convenient Administration: Intramuscular formulation allows for easy dosing in large animals.
• Cost-Effective: Provides long-term value with a 3-year shelf life and efficient dosing.

Important Considerations

Before administering amoxicillin injection, the following precautions must be observed:

• Allergies: Avoid use in animals with known hypersensitivity to β-lactam antibiotics.
• Withdrawal Periods: Adhere to the 28-day withdrawal period for meat and 4-hour period for milk to ensure safety.
• Storage: Keep the product sealed and protected from light to maintain potency.

About Shijiazhuang Shimu Pharmaceutical Co., Ltd.

As a reputable manufacturer of veterinary pharmaceuticals, Shijiazhuang Shimu Pharmaceutical Co., Ltd. (石家庄石牧药业有限公司) is committed to producing high-quality antibiotics like amoxicillin injection. The company adheres to stringent quality control standards, ensuring compliance with international veterinary medicine regulations. For more information about their products and services, visit the company website.

Scientific Validation and Regulatory Compliance

The efficacy and safety of amoxicillin injection are supported by scientific research and regulatory frameworks. According to the National Institute of Standards and Technology (NIST), antimicrobial agents like amoxicillin must undergo rigorous testing to ensure their pharmacokinetic profiles meet established benchmarks. This includes evaluating absorption, distribution, metabolism, and excretion (ADME) parameters, which align with the data provided for amoxicillin injection. Such validation underscores its reliability in veterinary applications.

Conclusion

Amoxicillin Injection by Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a trusted solution for managing bacterial infections in livestock. Its broad-spectrum activity, favorable pharmacokinetics, and ease of administration make it a preferred choice among veterinarians. By adhering to strict quality standards and regulatory guidelines, the company ensures that this product remains a cornerstone of veterinary medicine. For further details, explore the product page or contact the company directly.

References

NIST (National Institute of Standards and Technology): https://www.nist.gov/

Shijiazhuang Shimu Pharmaceutical Co., Ltd.: https://www.skyvetpharm.com

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