amoxicillin injection-Shijiazhuang Shimu Pharmaceutical Co., Ltd.|Veterinary Antibiotic,Infection Treatment

Amoxicillin Injection is a critical pharmaceutical product in veterinary medicine, designed to combat bacterial infections in livestock such as cattle and pigs. This article provides an in-depth analysis of its pharmacokinetic properties, clinical applications, safety profile, and the company behind its production, Shijiazhuang Shimu Pharmaceutical Co., Ltd.. With a focus on amoxicillin injection specifications and its role in modern veterinary care, this guide ensures a thorough understanding of its value in animal health.

Pharmacokinetic Properties of Amoxicillin Injection

Amoxicillin, a broad-spectrum antibiotic derived from the amino-penicillin family, is renowned for its efficacy against both Gram-positive and Gram-negative bacteria. Its mechanism of action involves inhibiting bacterial cell wall synthesis, making it a potent bactericidal agent. However, it is susceptible to β-lactamase enzymes produced by certain bacteria, which can limit its effectiveness in specific cases.

Key Pharmacokinetic Data

Understanding the pharmacokinetics of Amoxicillin Injection is essential for optimizing its therapeutic use:

• Peak Concentration (Cmax): In cattle, Cmax of 3.45 µg/ml is achieved 2.45 hours post-intramuscular administration. In pigs, the peak concentration reaches 3.54 µg/ml within 2 hours.
• Distribution: Amoxicillin distributes primarily to the extracellular compartment, with a low plasma protein binding rate (17%). It effectively diffuses into tissues such as the lungs, pleura, bronchial tissues, and synovial fluid.
• Metabolism: The drug is metabolized in the liver via hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20% of the original compound).
• Excretion: The majority of Amoxicillin is excreted via the kidneys in its active form, with secondary elimination through the biliary route and milk.

Clinical Applications and Indications

Amoxicillin Injection is indicated for treating infections caused by susceptible bacteria in veterinary settings. Its activity against specific pathogens makes it a preferred choice for respiratory diseases in cattle and pigs. Key applications include:

• Cattle: Effective against Mannheimia haemolytica and Pasteurella multocida, which are common causes of bovine respiratory disease.
• Pigs: Active against Pasteurella multocida, addressing respiratory infections in swine populations.

For detailed information on amoxicillin injection uses, visit the official product page.

Safety Profile and Adverse Reactions

While Amoxicillin Injection is generally well-tolerated, it is crucial to be aware of potential adverse effects and precautions:

• Allergic Reactions: As with all β-lactam antibiotics, hypersensitivity reactions may occur. It should not be administered to animals with a known allergy to penicillins.
• Local Reactions: Transient injection site reactions, such as swelling or redness, may occur but are typically mild and resolve spontaneously.
• Withdrawal Periods:
  • Cattle and Pigs: 28 days post-treatment.
  • Milk: 4 hours post-treatment to ensure safety for human consumption.

For safety guidelines, refer to the amoxicillin injection product specifications.

Storage and Packaging Details

Proper storage ensures the stability and efficacy of Amoxicillin Injection:

• Storage Conditions: Keep the product sealed, protected from light, and out of reach of children.
• Packaging: Available in 100ml bottles, with a shelf life of 3 years.

Technical Specifications Table

Parameter	Details
Active Ingredient	Amoxicillin 150mg/ml
Indication	Treatment of Gram-positive and Gram-negative bacterial infections
Pharmacokinetic Profile	Time-dependent antibiotic with peak concentrations in cattle (2.45h) and pigs (2h)
Withdrawal Periods	Cattle/Pigs: 28 days; Milk: 4 hours
Storage	Sealed, light-protected, shelf life 3 years

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Based in China, Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reputable manufacturer of veterinary pharmaceuticals, specializing in antibiotics and other critical veterinary solutions. The company adheres to stringent quality control standards to ensure the safety and efficacy of its products, including veterinary amoxicillin injection.

Expert Insights and Regulatory Compliance

According to the National Institute of Standards and Technology (NIST), the development of pharmaceuticals like Amoxicillin Injection involves rigorous testing to meet safety and efficacy benchmarks. While NIST primarily focuses on standards for measurement and technology, its guidelines on analytical methods and quality assurance are indirectly relevant to pharmaceutical production processes.

Source: https://www.nist.gov

Conclusion

Amoxicillin Injection stands as a vital tool in veterinary medicine, offering a reliable solution for bacterial infections in livestock. Its favorable pharmacokinetic profile, broad-spectrum activity, and adherence to safety protocols make it an essential product for animal health professionals. For more information on amoxicillin injection and its applications, visit the official website of Shijiazhuang Shimu Pharmaceutical Co., Ltd..

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