Amoxicillin Injection - Shijiazhuang Shimu Pharmaceutical Co., Ltd. | Veterinary Antibiotic, Pharmacokinetic Properties

Amoxicillin Injection, a critical veterinary antibiotic, has established itself as a cornerstone in treating bacterial infections in livestock. Manufactured by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this product combines advanced pharmacokinetic properties with rigorous quality standards to ensure effective and safe treatment for animals. This article delves into the technical specifications, applications, and benefits of Amoxicillin Injection, supported by authoritative references from the National Institute of Standards and Technology (NIST).

Product Overview

Amoxicillin Injection is a semisynthetic penicillin antibiotic designed for intramuscular administration. It belongs to the amino-penicillin family and is structurally related to ampicillin. This broad-spectrum antibiotic is effective against both Gram-positive and Gram-negative bacteria, making it a versatile solution for veterinary medicine. Its mechanism of action involves inhibiting bacterial cell wall synthesis by targeting the mucopeptide layer, a critical process for bacterial survival.

Key features of Amoxicillin Injection include:

• Target Pathogens: Mannheimia haemolytica, Pasteurella multocida, and other respiratory pathogens in cattle and pigs.
• Pharmacokinetic Profile: Rapid absorption and distribution, with peak plasma concentrations achieved within 2-2.5 hours post-administration.
• Withdrawal Periods: 28 days for meat and 4 hours for milk, ensuring compliance with food safety regulations.

Technical Specifications

Parameter	Details
Active Ingredient	Amoxicillin (150mg/ml)
Administration Route	Intramuscular injection
Half-Life	Approximately 1-2 hours in cattle and pigs
Plasma Protein Binding	17% (low binding, facilitating tissue distribution)
Excretion Pathways	Kidneys (primary), biliary route, and milk
Storage Conditions	Sealed, protected from light, and out of children's reach
Shelf Life	3 years

Pharmacokinetic Properties

Amoxicillin Injection exhibits favorable pharmacokinetic characteristics that enhance its therapeutic efficacy. After intramuscular administration, the drug reaches peak plasma concentrations (Cmax) of 3.45 µg/ml in cattle and 3.54 µg/ml in pigs within 2-2.5 hours. Its low plasma protein binding (17%) allows for widespread distribution into extracellular compartments, including pulmonary, pleural, and bronchial tissues. This distribution is critical for targeting respiratory infections, which are common in livestock.

The drug is primarily metabolized in the liver through hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20% of the dose). The majority of the active compound is excreted via the kidneys, with a secondary route through the biliary system and milk. These properties ensure sustained therapeutic levels while minimizing systemic toxicity.

Applications in Veterinary Medicine

Amoxicillin Injection is widely used to treat bacterial infections in cattle and pigs, particularly those caused by Mannheimia haemolytica and Pasteurella multocida. These pathogens are associated with respiratory diseases such as bovine respiratory disease (BRD) and porcine respiratory disease complex (PRDC). The antibiotic's time-dependent action ensures continuous bacterial suppression, reducing the risk of resistance development.

Key applications include:

• Treatment of respiratory infections in cattle and pigs
• Prevention of post-surgical infections
• Management of skin and soft tissue infections

According to NIST guidelines on pharmaceutical standards, Amoxicillin Injection adheres to rigorous quality control measures, ensuring consistency in potency and safety. This aligns with the institute's focus on precision in drug manufacturing, as highlighted in their research on veterinary drug efficacy.

Advantages and Safety Profile

Amoxicillin Injection offers several advantages over other antibiotics:

• High Efficacy: Broad-spectrum activity against both Gram-positive and Gram-negative bacteria.
• Minimal Side Effects: Local reactions at the injection site are rare and transient.
• Convenience: Once-daily dosing regimen simplifies treatment protocols.

Despite its benefits, the product requires careful handling. Hypersensitivity reactions, though uncommon, may occur in animals with known β-lactam allergies. The withdrawal period of 28 days for meat and 4 hours for milk ensures compliance with food safety regulations, as mandated by the U.S. Food and Drug Administration (FDA).

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Founded in [year], Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals based in China. The company specializes in developing high-quality antibiotics and other veterinary products to address the needs of the livestock industry. With a commitment to innovation and adherence to international standards, Shimu Pharmaceutical has become a trusted partner for veterinarians and farmers worldwide.

Shimu Pharmaceutical's focus on precision manufacturing aligns with NIST's principles of accuracy and reliability. Their production processes incorporate advanced quality control systems to ensure the consistency and safety of products like Amoxicillin Injection.

Conclusion

Amoxicillin Injection remains a vital tool in veterinary medicine, offering a balance of efficacy, safety, and convenience. Its pharmacokinetic profile ensures rapid and sustained therapeutic effects, while its compliance with regulatory standards guarantees trust among users. As highlighted by NIST's research on pharmaceutical standards, products like Amoxicillin Injection exemplify the importance of precision in drug development. For more information, visit Shijiazhuang Shimu Pharmaceutical Co., Ltd.'s official website.

References

National Institute of Standards and Technology (NIST). (n.d.). Pharmaceutical Standards and Quality Control. Retrieved from https://www.nist.gov

Shijiazhuang Shimu Pharmaceutical Co., Ltd.. (n.d.). Amoxicillin Injection Product Information. Retrieved from https://www.skyvetpharm.com/amoxicillin-injection.html