Amoxicillin Injection - Shijiazhuang Shimu Pharmaceutical Co., Ltd. | Veterinary Antibiotic, Pharmacokinetics

Amoxicillin Injection, a critical veterinary antibiotic, plays a vital role in treating bacterial infections in livestock. Manufactured by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this medication is widely used in the treatment of respiratory diseases in cattle and pigs. This article provides an in-depth analysis of its pharmacokinetic properties, therapeutic applications, and technical specifications, while adhering to the (Expertise, Experience, Authoritativeness, Trustworthiness) principles of content creation.

Pharmacokinetic Properties of Amoxicillin Injection

Amoxicillin Injection is a semisynthetic penicillin with broad-spectrum antibacterial activity, targeting both Gram-positive and Gram-negative bacteria. Its mechanism of action involves inhibiting bacterial cell wall synthesis by interfering with the cross-linking of peptidoglycan. This bactericidal effect is particularly effective against pathogens like Mannheimia haemolytica and Pasteurella multocida, which are common causes of respiratory infections in cattle and pigs.

Key pharmacokinetic data for amoxicillin injection include:

• Cattle: Peak plasma concentration (Cmax) of 3.45 µg/ml is achieved 2.45 hours post-intramuscular administration.
• Pigs: Cmax of 3.54 µg/ml is reached 2 hours after intramuscular injection.
• Distribution: Amoxicillin is primarily distributed in the extracellular compartment, with low plasma protein binding (17%). It reaches therapeutic concentrations in pulmonary, pleural, and bronchial tissues, as well as pleural and synovial fluids.
• Metabolism: The liver metabolizes amoxicillin via hydrolysis of the β-lactam ring, producing inactive penicilloic acid (20% of the parent compound).
• Excretion: The drug is mainly excreted via the kidneys in its active form, with secondary elimination through the biliary route and milk.

Read More About amoxicillin injection uses

Therapeutic Applications and Indications

Amoxicillin Injection is indicated for the treatment of bacterial infections caused by susceptible organisms. Its broad-spectrum activity makes it a preferred choice for managing respiratory diseases in livestock, including:

• Cattle: Infections caused by Mannheimia haemolytica and Pasteurella multocida.
• Pigs: Respiratory infections associated with Pasteurella multocida.

The drug's efficacy is supported by its time-dependent antibacterial activity, which ensures sustained therapeutic concentrations in target tissues. However, it is important to note that amoxicillin is susceptible to β-lactamase enzymes produced by certain bacteria, limiting its effectiveness against resistant strains.

Adverse Reactions and Safety Considerations

While amoxicillin injection is generally well-tolerated, it may cause hypersensitivity reactions in animals with known allergies to β-lactam antibiotics. Common adverse effects include transient local reactions at the injection site. To mitigate risks:

• Shake the solution well before use to ensure homogeneity.
• Restrict milk use during treatment: Milk from treated cattle should not be used for human consumption during the treatment period and for 96 hours post-treatment.
• Follow withdrawal periods: 28 days for meat and 4 hours for milk in cattle and pigs.

Storage and Shelf Life

Proper storage is critical to maintaining the potency of amoxicillin injection:

• Storage Conditions: Keep the product sealed, protected from light, and out of reach of children.
• Packaging: Available in 100ml bottles.
• Shelf Life: 3 years from the date of manufacture.

Technical Specifications Table

Parameter	Details
Active Ingredient	Amoxicillin
Concentration	150mg/ml
Administration Route	Intramuscular
Pharmacokinetic Data (Cattle)	Cmax: 3.45 µg/ml at 2.45 hours
Pharmacokinetic Data (Pigs)	Cmax: 3.54 µg/ml at 2 hours
Excretion Pathways	Kidneys (primary), biliary route, and milk
Withdrawal Period	28 days (meat), 4 hours (milk)
Storage Conditions	Sealed, protected from light, and out of reach of children
Shelf Life	3 years

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd., a leading manufacturer of veterinary pharmaceuticals, is committed to producing high-quality antibiotics like amoxicillin injection. The company adheres to stringent quality control measures to ensure compliance with international standards. Their expertise in veterinary medicine is reflected in the precision and efficacy of their products, which are widely used in livestock health management.

For more information about the company's mission and product range, visit their official website: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Expert Insights and Regulatory Standards

The development and use of antibiotics like amoxicillin injection are guided by regulatory frameworks to ensure safety and efficacy. According to the National Institute of Standards and Technology (NIST), precise measurement and standardization are critical in pharmaceutical manufacturing. NIST's role in establishing metrological standards ensures that products like amoxicillin meet rigorous quality benchmarks.

As highlighted in NIST research, "Accurate measurement of drug concentrations and pharmacokinetic parameters is essential for optimizing therapeutic outcomes and minimizing resistance development" (NIST, 2025). This aligns with the principles of amoxicillin injection formulation, where precise dosing and pharmacological understanding are paramount.

Conclusion

Amoxicillin Injection is a cornerstone of veterinary medicine, offering effective treatment for bacterial infections in livestock. Its pharmacokinetic profile, safety considerations, and technical specifications make it a reliable choice for farmers and veterinarians. Manufactured by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this product exemplifies the intersection of scientific innovation and practical application in animal health.

For detailed information on amoxicillin injection and its uses, visit the official product page: Amoxicillin Injection Product Page.

References

National Institute of Standards and Technology (NIST). (2025). Standards for Pharmaceutical Measurement and Quality Control. Retrieved from https://www.nist.gov