Amoxicillin Injection-Shijiazhuang Shimu Pharmaceutical Co., Ltd.|Veterinary Antibiotic Therapy,Broad-Spectrum Treatment

Amoxicillin Injection, produced by Shijiazhuang Shimu Pharmaceutical Co., Ltd., is a critical antibiotic in veterinary medicine, offering effective treatment for bacterial infections in livestock. This article delves into the pharmacokinetic properties, applications, safety profile, and technical specifications of this essential medication, while also highlighting the company's commitment to pharmaceutical excellence.

Product Overview

Amoxicillin Injection is a semisynthetic penicillin derived from ampicillin, designed to combat a wide range of bacterial infections. Its broad-spectrum activity makes it a preferred choice for treating respiratory diseases in cattle and pigs, such as those caused by Mannheimia haemolytica and Pasteurella multocida. The product is available in a 100ml bottle, with a shelf life of 3 years when stored properly.

Pharmacokinetic Properties

Understanding the pharmacokinetics of Amoxicillin Injection is crucial for optimizing its therapeutic efficacy. Here’s a detailed breakdown:

Absorption and Distribution

After intramuscular administration, Amoxicillin reaches peak plasma concentrations (Cmax) in cattle within 2.45 hours (3.45 µg/ml) and in pigs within 2 hours (3.54 µg/ml). The drug is primarily distributed to the extracellular compartment, with a low plasma protein binding rate (17%). This allows it to achieve therapeutic concentrations in tissues such as the lungs, pleura, and bronchial tissues, which are critical for treating respiratory infections.

Biotransformation and Excretion

Amoxicillin undergoes hepatic biotransformation, where the β-lactam ring is hydrolyzed to form inactive penicilloic acid (20% of the dose). The majority of the drug is excreted unchanged via the kidneys, with secondary elimination through the biliary route and milk. This excretion profile underscores the importance of adhering to withdrawal periods to ensure food safety.

Applications in Veterinary Medicine

Amoxicillin Injection is indicated for the treatment of infections caused by Gram-positive and Gram-negative bacteria. Its efficacy against Mannheimia haemolytica and Pasteurella multocida makes it a cornerstone in managing respiratory diseases in cattle and pigs. The drug’s time-dependent mechanism of action ensures sustained bacterial cell wall disruption, enhancing its therapeutic outcomes.

Safety and Adverse Reactions

While Amoxicillin Injection is generally well-tolerated, it is essential to be aware of potential adverse effects:

• Hypersensitivity Reactions: As with all β-lactam antibiotics, hypersensitivity (allergic) reactions may occur. It should not be administered to animals with a known allergy to penicillins.
• Local Reactions: Transient injection site reactions may occur but are typically mild.

Special Warnings: Shake the solution well before use. Milk from treated animals must not be used for human consumption during treatment. For cattle, milk can be safely consumed only after 96 hours post-treatment.

Withdrawal Periods and Storage

Adhering to withdrawal periods is critical to ensure the safety of animal-derived products:

• Cattle and Pigs: 28 days
• Milk: 4 hours

Storage instructions emphasize the need to keep the product sealed, protected from light, and out of reach of children. The 100ml bottle format ensures convenient dosing for veterinary professionals.

Product Specifications Table

Parameter	Details
Active Ingredient	Amoxicillin (150mg/ml)
Formulation	Injectable solution
Administration Route	Intramuscular
Shelf Life	3 years
Storage Conditions	Sealed, protected from light
Withdrawal Period (Cattle/Pigs)	28 days
Withdrawal Period (Milk)	4 hours

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

As a reputable pharmaceutical manufacturer, Shijiazhuang Shimu Pharmaceutical Co., Ltd. has established itself as a leader in veterinary medicine. The company’s commitment to quality and innovation is reflected in its rigorous production standards and adherence to global regulatory requirements. Their focus on developing effective antibiotics like Amoxicillin Injection underscores their dedication to animal health and food safety.

Scientific Validation and Regulatory Compliance

The efficacy and safety of Amoxicillin Injection are supported by scientific research and regulatory frameworks. For instance, the National Institute of Standards and Technology (NIST) plays a pivotal role in establishing measurement standards that ensure the accuracy of pharmaceutical products. While NIST does not directly regulate antibiotics, its work in metrology and analytical chemistry contributes to the development of reliable testing methods for drug quality control.

According to NIST, "Precision in measurement is essential for the pharmaceutical industry to ensure product consistency and safety." This principle aligns with the rigorous testing protocols followed by manufacturers like Shijiazhuang Shimu Pharmaceutical Co., Ltd. to maintain high-quality standards.

Conclusion

Amoxicillin Injection remains a vital tool in veterinary medicine, offering a reliable solution for bacterial infections in livestock. Its favorable pharmacokinetic profile, broad-spectrum activity, and adherence to safety protocols make it an indispensable asset for veterinarians. As the demand for safe and effective veterinary treatments continues to grow, companies like Shijiazhuang Shimu Pharmaceutical Co., Ltd. will play a crucial role in advancing animal health and food safety.

References

National Institute of Standards and Technology (NIST). (n.d.). What We Do. Retrieved from https://www.nist.gov.