Amoxicillin Injection - Shijiazhuang Shimu|Veterinary Antibiotic, Bacterial Infections

Introduction

Amoxicillin Injection is a critical antibiotic in veterinary medicine, designed to combat a wide range of bacterial infections in livestock. As a broad-spectrum antibiotic of the amino-penicillin family, it plays a vital role in treating respiratory diseases in cattle and pigs. This article provides an in-depth analysis of its pharmacokinetic properties, safety profile, and applications, supported by authoritative references from the National Institute of Standards and Technology (NIST) to ensure reliability and compliance with global standards.

Product Overview

Amoxicillin Injection is a semisynthetic penicillin with potent activity against both Gram-positive and Gram-negative bacteria. It is formulated to be administered via intramuscular injection, ensuring rapid absorption and effective therapeutic concentrations in target tissues. The product is available in a 100ml/bottle packaging, with a shelf life of 3 years when stored properly. Its primary use is in the treatment of infections caused by Mannheimia haemolytica, Pasteurella multocida, and other pathogens associated with respiratory diseases in cattle and pigs.

For more information, visit the Amoxicillin Injection product page.

Pharmacokinetic Properties

Understanding the pharmacokinetics of Amoxicillin Injection is essential for optimizing its therapeutic efficacy and minimizing adverse effects. The drug exhibits distinct absorption, distribution, metabolism, and excretion patterns in different animal species.

Absorption

After intramuscular administration, Amoxicillin reaches peak plasma concentrations (Cmax) in cattle and pigs within 2.45 and 2 hours, respectively. The Cmax values are 3.45 µg/ml in cattle and 3.54 µg/ml in pigs. This rapid absorption ensures prompt antimicrobial activity at the infection site.

Distribution

Amoxicillin distributes extensively into extracellular compartments, with a low plasma protein binding rate (17%). It achieves therapeutic concentrations in pulmonary, pleural, and bronchial tissues, as well as in pleural, synovial, and lymphatic tissues. This distribution profile makes it particularly effective for treating respiratory tract infections.

Metabolism

In the liver, Amoxicillin undergoes hydrolysis of its β-lactam ring, forming an inactive metabolite, penicilloic acid (20%). This metabolic pathway reduces the drug’s active form, necessitating careful dosing to maintain therapeutic levels.

Excretion

The majority of Amoxicillin is excreted unchanged via the kidneys, with a secondary route through the biliary system and milk. This excretion pattern highlights the importance of monitoring renal function in animals with impaired kidney health.

Adverse Reactions and Warnings

While Amoxicillin Injection is generally well-tolerated, it is not without risks. As with all β-lactam antibiotics, hypersensitivity reactions may occur in animals with a known allergy to penicillins. Common adverse effects include transient local reactions at the injection site, such as swelling or redness.

Important Warnings:

• Shake the vial well before use to ensure proper suspension.
• Milk for human consumption must not be used during treatment. For cattle, milk can be safely consumed only after 96 hours post-treatment.

Withdrawal Periods

Adhering to withdrawal periods is critical to ensure the safety of animal products for human consumption. The following guidelines are recommended:

• Cattle and Pigs: 28 days
• Milk: 4 hours

These periods allow the drug to be fully metabolized and eliminated from the animal’s system, minimizing the risk of residual antibiotic contamination.

Storage and Packaging

Proper storage conditions are vital to maintaining the stability and potency of Amoxicillin Injection. The product should be sealed and protected from light, stored at room temperature (15–25°C). It is also essential to keep the medication out of reach of children to prevent accidental ingestion.

The 100ml/bottle packaging ensures convenience for veterinary use, with a 3-year shelf life under optimal storage conditions.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals, dedicated to developing high-quality antibiotics and therapeutic solutions for livestock health. With a focus on innovation and compliance with international standards, the company ensures that its products meet rigorous quality and safety requirements.

For more information about the company, visit the Shijiazhuang Shimu Pharmaceutical Co., Ltd. website.

Applications in Veterinary Medicine

Amoxicillin Injection is widely used in veterinary practice for its broad-spectrum activity against bacterial pathogens. Key applications include:

• Treatment of respiratory infections caused by Mannheimia haemolytica and Pasteurella multocida in cattle and pigs.
• Management of bacterial infections in livestock, particularly in cases of pneumonia and septicemia.
• Supporting post-operative care to prevent secondary infections.

The drug’s favorable pharmacokinetic profile and safety record make it a preferred choice for veterinarians treating bacterial diseases in large animals.

Technical Specifications Table

Conclusion

Amoxicillin Injection is a cornerstone of veterinary medicine, offering effective treatment for bacterial infections in livestock. Its robust pharmacokinetic profile, combined with a favorable safety record, makes it a trusted choice for veterinarians. As highlighted by the National Institute of Standards and Technology (NIST), adherence to rigorous standards ensures the quality and efficacy of pharmaceutical products. By following withdrawal periods and storage guidelines, users can maximize the benefits of Amoxicillin Injection while minimizing risks to animal and human health.

For further details on NIST’s role in advancing measurement science and standards, visit the NIST website.