Amoxicillin Injection - Shijiazhuang Shimu|Veterinary Use, Safety

Amoxicillin injection is a critical veterinary medication used to treat bacterial infections in livestock. As a semisynthetic penicillin, it belongs to the amino-penicillin family and exhibits broad-spectrum activity against both Gram-positive and Gram-negative bacteria. This article provides an in-depth analysis of its pharmacokinetic properties, clinical applications, safety profile, and the company behind its production. For more details, visit the product page.

Product Overview

Amoxicillin injection is a sterile solution containing 150mg of amoxicillin per milliliter. It is specifically formulated for veterinary use to address infections caused by susceptible microorganisms. The product is available in 100ml bottles and has a shelf life of three years when stored properly.

Pharmacokinetic Properties

Understanding the pharmacokinetics of amoxicillin is essential for optimizing its therapeutic efficacy. Here are key details:

Bioavailability and Distribution

After intramuscular administration, amoxicillin reaches peak plasma concentrations (Cmax) within 2 to 2.45 hours in cattle and pigs. The Cmax values are 3.45 µg/ml in cattle and 3.54 µg/ml in pigs. Its low plasma protein binding (17%) facilitates distribution into extracellular compartments, including pulmonary, pleural, bronchial, and synovial tissues. This distribution ensures effective concentrations in target areas of infection.

Metabolism and Excretion

Amoxicillin is primarily metabolized in the liver through hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20% of the parent compound). The majority of the drug is excreted unchanged via the kidneys, with secondary elimination through the biliary route and milk. This renal excretion pathway is critical for determining withdrawal periods.

Key Pharmacokinetic Parameters

Parameter	Cattle	Pigs
Cmax (µg/ml)	3.45	3.54
Time to Cmax (hours)	2.45	2
Plasma Protein Binding (%)	17	17
Renal Excretion (%)	Major	Major

Clinical Applications

Amoxicillin injection is indicated for treating bacterial infections in cattle and pigs. It is particularly effective against the following pathogens:

• Mannheimia haemolytica: A common cause of respiratory disease in cattle.
• Pasteurella multocida: Involved in respiratory infections in both cattle and pigs.

Its bactericidal action against these organisms makes it a preferred choice for managing respiratory conditions in livestock. For detailed usage guidelines, refer to the product documentation.

Adverse Reactions and Safety

While generally well-tolerated, amoxicillin injection may cause adverse effects, including:

• Hypersensitivity Reactions: Allergic responses to β-lactam antibiotics are possible. It should not be administered to animals with known allergies to penicillins.
• Local Reactions: Transient injection site reactions may occur but are typically mild.

Special Warnings: Shake the vial well before use. Milk from treated animals must not be used for human consumption during treatment. For cattle, milk can be safely consumed only after 96 hours post-treatment. Read more about safety precautions.

Withdrawal Periods

Withdrawal periods are critical to ensure food safety and compliance with regulatory standards:

• Cattle and Pigs: 28 days
• Milk: 4 hours

These periods allow the drug to be fully metabolized and excreted, minimizing residue risks in animal products.

Storage and Handling

Proper storage is essential to maintain the stability and potency of amoxicillin injection:

• Storage Conditions: Keep sealed, protect from light, and store at room temperature (15–30°C).
• Child Safety: Keep out of reach of children.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals, specializing in antibiotics and antimicrobial agents. With a commitment to quality and innovation, the company adheres to stringent production standards to ensure the safety and efficacy of its products. Their expertise in veterinary medicine has made them a trusted supplier for livestock health solutions. Learn more about the company here.

Why Choose Amoxicillin Injection?

Amoxicillin injection offers several advantages for veterinary use:

• Broad-Spectrum Activity: Effective against a wide range of bacteria, including those causing respiratory infections.
• Optimized Pharmacokinetics: Rapid absorption and distribution ensure quick therapeutic action.
• Proven Safety Profile: Minimal adverse effects when used as directed.

Conclusion

Amoxicillin injection is a vital tool in veterinary medicine, providing effective treatment for bacterial infections in cattle and pigs. Its favorable pharmacokinetic properties, combined with a robust safety profile, make it a preferred choice for livestock health management. For comprehensive information on its use and specifications, visit the product page.

References

1. National Institute of Standards and Technology (NIST) - For standards and guidelines on pharmaceutical quality and safety.

2. Shijiazhuang Shimu Pharmaceutical Co., Ltd. - Manufacturer of amoxicillin injection.