Amoxicillin Injection-Veterinary Antibiotic|Bacterial Infection Treatment&Broad-Spectrum

Amoxicillin injection is a critical tool in the veterinary pharmaceutical industry, offering effective treatment for bacterial infections in livestock. This article delves into the pharmacokinetic properties, technical specifications, applications, and the company behind this essential medication. Whether you're a veterinarian, farm manager, or pharmaceutical professional, this guide provides in-depth insights into Amoxicillin Injection and its role in modern animal healthcare.

Product Overview

Amoxicillin injection is a semisynthetic penicillin antibiotic designed to combat a wide range of bacterial infections in animals. As a broad-spectrum antibiotic, it targets both Gram-positive and Gram-negative bacteria, making it a versatile choice for treating respiratory and other systemic infections in cattle and pigs. The product is formulated as a sterile solution, with each milliliter containing 150mg of amoxicillin. Its formulation ensures rapid absorption and distribution, providing effective therapeutic levels in the bloodstream and tissues.

Pharmacokinetic Properties

Understanding the pharmacokinetic profile of amoxicillin is essential for optimizing its therapeutic use. Here’s a detailed breakdown of its behavior in the body:

• Onset of Action: After intramuscular administration, amoxicillin reaches peak plasma concentration (Cmax) within 2 to 2.45 hours in cattle and pigs. For cattle, the Cmax is 3.45 µg/ml, while pigs achieve a slightly higher concentration of 3.54 µg/ml.
• Distribution: Amoxicillin distributes primarily to the extracellular compartment due to its low plasma protein binding (17%). It effectively reaches tissues such as the lungs, pleura, bronchial tissues, and synovial fluid, ensuring coverage against pathogens in these areas.
• Metabolism: The drug undergoes partial hepatic metabolism, with approximately 20% being converted into inactive penicilloic acid. This metabolic pathway ensures minimal systemic toxicity while maintaining efficacy.
• Excretion: Amoxicillin is primarily excreted via the kidneys in its active form, with secondary routes including the biliary system and milk. This excretion pattern is crucial for determining withdrawal periods and ensuring safety for both animals and consumers.

Technical Specifications

Parameter	Details
Active Ingredient	Amoxicillin (150mg/ml)
Indication	Treatment of infections caused by Gram-positive and Gram-negative bacteria
Withdrawal Period	Cattle and pigs: 28 days; Milk: 4 hours
Storage	Seal, protect from light, and keep out of reach of children
Packaging	100ml/bottle
Shelf Life	3 years

Key Features and Benefits

Amoxicillin Injection offers several advantages that make it a preferred choice in veterinary medicine:

• Broad-Spectrum Activity: Effective against a wide range of bacteria, including Mannheimia haemolytica and Pasteurella multocida, which are common causes of respiratory diseases in cattle and pigs.
• Time-Dependent Efficacy: Its mechanism of action is dependent on prolonged exposure to the bacteria, making it ideal for treating chronic or recurrent infections.
• Low Toxicity: Amoxicillin is generally well-tolerated, with minimal side effects when used as directed.
• Convenient Administration: Available in a ready-to-use formulation, it simplifies the treatment process for veterinarians and farm staff.

Applications in Veterinary Medicine

Amoxicillin injection is widely used in the treatment of bacterial infections across various livestock species. Its primary applications include:

• Respiratory Infections: Effective against Pasteurella multocida in pigs and Mannheimia haemolytica in cattle, which are leading causes of pneumonia and other respiratory diseases.
• Systemic Infections: Treats infections in the skin, soft tissues, and other organs caused by susceptible bacteria.
• Post-Operative Prophylaxis: Used to prevent infections following surgical procedures in animals.

Important Considerations

While Amoxicillin Injection is a powerful medication, it is essential to adhere to safety guidelines:

• Allergies: Avoid use in animals with a known hypersensitivity to beta-lactam antibiotics.
• Adverse Reactions: Although rare, transient local reactions at the injection site may occur. Monitor animals closely during treatment.
• Milk Withdrawal: Do not use milk from treated animals for human consumption until the withdrawal period has elapsed. For cattle, this period is 96 hours after the last dose.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Founded in Shijiazhuang Shimu Pharmaceutical Co., Ltd., this company has established itself as a reliable provider of veterinary pharmaceuticals. With a focus on quality and innovation, Shijiazhuang Shimu has developed a range of products that meet international standards for safety and efficacy. Their commitment to research and development ensures that their products, such as amoxicillin injection, are backed by rigorous testing and clinical validation.

Ensuring Safety and Efficacy

The development and use of antibiotics like amoxicillin require adherence to stringent safety protocols. According to the National Institute of Standards and Technology (NIST), accurate measurement and standardization are critical in pharmaceutical manufacturing. NIST's work in metrology and analytical chemistry plays a vital role in ensuring the consistency and reliability of drug formulations. While the provided NIST link is currently unavailable, the principles of measurement and quality control outlined by NIST are foundational to the pharmaceutical industry.

Conclusion

Amoxicillin Injection is an essential medication in veterinary medicine, offering effective treatment for bacterial infections in livestock. Its broad-spectrum activity, favorable pharmacokinetic profile, and ease of administration make it a preferred choice for veterinarians. By understanding its technical specifications, applications, and safety considerations, professionals can optimize its use and ensure the health and well-being of animals.

References

National Institute of Standards and Technology (NIST) (2025). Metrology and Pharmaceutical Standards. Retrieved from https://www.nist.gov/ (Note: This link is currently unavailable. For further information on NIST's role in pharmaceutical research, refer to their official publications and resources.)

Shijiazhuang Shimu Pharmaceutical Co., Ltd. (2025). Product Specifications and Safety Information. Retrieved from https://www.skyvetpharm.com/amoxicillin-injection.html