Amoxicillin Injection-Veterinary Antibiotic | Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Amoxicillin Injection is a critical veterinary antibiotic designed to combat a wide range of bacterial infections in livestock. Developed by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this product exemplifies the intersection of pharmaceutical innovation and animal health. This article delves into its pharmacokinetic properties, advantages, technical specifications, and applications, while also highlighting the company's commitment to quality and safety.

Product Overview

Amoxicillin Injection is a semisynthetic penicillin with broad-spectrum antibacterial activity. It is specifically formulated for use in cattle and pigs, targeting pathogens like Mannheimia haemolytica and Pasteurella multocida—common culprits behind respiratory diseases. The product is available in a 100ml bottle, with a shelf life of 3 years when stored properly.

Pharmacokinetic Properties

Understanding the pharmacokinetics of Amoxicillin Injection is essential for optimizing its therapeutic efficacy. Here's a detailed breakdown:

Absorption and Distribution

After intramuscular administration, Amoxicillin reaches peak plasma concentrations (Cmax) in amoxicillin injection 1g at 2.45 hours in cattle and 2 hours in pigs. Its low plasma protein binding (17%) allows it to distribute efficiently into extracellular compartments, including pulmonary, pleural, and bronchial tissues. This distribution pattern ensures effective concentrations in areas prone to infection.

Metabolism and Excretion

Amoxicillin undergoes hepatic metabolism, primarily through hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20%). The majority of the drug is excreted via the kidneys in its active form, with secondary excretion through the biliary route and milk. This excretion profile underscores the importance of adhering to withdrawal periods to prevent residues in food products.

Advantages of Amoxicillin Injection

Amoxicillin Injection offers several distinct advantages that make it a preferred choice in veterinary medicine:

• Broad-Spectrum Activity: Effective against both Gram-positive and Gram-negative bacteria, including key pathogens in respiratory infections.
• Time-Dependent Efficacy: Its bactericidal action is maximized with sustained drug concentrations, aligning with dosing protocols for optimal outcomes.
• Minimal Adverse Reactions: While hypersensitivity is a risk, local reactions at the injection site are typically transient and manageable.
• Convenient Formulation: The 100ml bottle size ensures ease of administration, while the 3-year shelf life supports long-term storage.

Applications in Veterinary Medicine

Amoxicillin Injection is widely used in the treatment of bacterial infections in livestock, particularly in the following scenarios:

Respiratory Diseases

The product is specifically indicated for infections caused by Mannheimia haemolytica and Pasteurella multocida in cattle and pigs. Its ability to penetrate lung tissues makes it ideal for addressing conditions like pneumonia and bronchitis.

Systemic Infections

Due to its distribution into extracellular fluids and tissues, Amoxicillin Injection is effective in managing systemic infections such as septicemia and wound infections.

Important Safety Information

While Amoxicillin Injection is generally safe, certain precautions must be observed:

• Allergy Considerations: It should not be used in animals with known hypersensitivity to β-lactam antibiotics. Cross-reactivity with other penicillins is possible.
• Withdrawal Periods: The withdrawal period for meat is 28 days, and milk must be discarded for 4 hours post-treatment to ensure food safety.
• Storage: Keep the product sealed, protected from light, and out of reach of children.

Technical Specifications

Parameter	Details
Active Ingredient	Amoxicillin 150mg/ml
Indication	Treatment of bacterial infections caused by Gram-positive and Gram-negative bacteria
Administration Route	Intramuscular
Shelf Life	3 years
Packaging	100ml/bottle
Withdrawal Period	Cattle and pigs: 28 days; Milk: 4 hours

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

As a leading pharmaceutical company in China, Shijiazhuang Shimu Pharmaceutical Co., Ltd. is dedicated to developing high-quality veterinary products. With a focus on innovation and compliance, the company ensures its products meet stringent safety and efficacy standards. Their commitment to research and development aligns with global veterinary health initiatives, as highlighted by the National Institute of Standards and Technology (NIST)’s emphasis on precision and measurement in pharmaceutical manufacturing.

References and Authority

The information provided aligns with the principles of NIST, which underscores the importance of accurate measurements and standards in scientific and industrial applications. While NIST does not directly regulate veterinary pharmaceuticals, its work in metrology and quality control serves as a benchmark for industries worldwide.

References:

• National Institute of Standards and Technology (NIST)

For more details about amoxicillin injection uses and other products, visit Shijiazhuang Shimu Pharmaceutical Co., Ltd..