Amoxicillin Injection-Veterinary Solution by Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Amoxicillin Injection is a vital veterinary medication designed to combat bacterial infections in livestock, particularly in cattle and pigs. Manufactured by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this antibiotic belongs to the amino-penicillin family and is widely used for its broad-spectrum efficacy. This article explores the product's features, advantages, technical specifications, application scenarios, and the company's background, while adhering to Google's (Experience, Expertise, Authoritativeness, Trustworthiness) principles.

Product Features and Advantages

Amoxicillin Injection is a time-dependent antibiotic that effectively targets both Gram-positive and Gram-negative bacteria. Its mechanism of action involves inhibiting bacterial cell wall synthesis, making it a potent bactericidal agent. The product's key features include:

• Broad-Spectrum Activity: Effective against pathogens like Mannheimia haemolytica and Pasteurella multocida, which are common in respiratory infections in cattle and pigs.
• Fast Onset of Action: Achieves peak plasma concentrations (Cmax) within 2–2.45 hours after intramuscular administration, ensuring rapid therapeutic effects.
• Low Plasma Protein Binding: Only 17% of the drug binds to plasma proteins, allowing it to distribute efficiently into tissues such as the lungs, pleura, and bronchial tissues.
• Short Withdrawal Periods: 28 days for meat and 4 hours for milk, ensuring compliance with food safety regulations.

The Shijiazhuang Shimu Pharmaceutical Co., Ltd. emphasizes quality and safety, as reflected in the product's comprehensive formulation. Each milliliter contains 150 mg of amoxicillin, making it a concentrated solution for easy dosing in large animals.

Pharmacokinetic Properties

The pharmacokinetics of Amoxicillin Injection are critical to its efficacy. After intramuscular administration:

• Cattle: Cmax reaches 3.45 µg/ml at 2.45 hours.
• Pigs: Cmax reaches 3.54 µg/ml at 2 hours.

The drug is primarily excreted via the kidneys, with a minor route through the biliary system and milk. Its low protein binding (17%) facilitates diffusion into extracellular compartments, including pleural and synovial fluids. However, it is susceptible to beta-lactamase enzymes, which may limit its effectiveness against resistant strains.

Application Scenarios

Amoxicillin Injection is primarily used to treat respiratory infections in cattle and pigs. Specific applications include:

• Respiratory Diseases: Targeting Mannheimia haemolytica and Pasteurella multocida, which cause conditions like bovine respiratory disease (BRD) and swine pneumonia.
• Systemic Infections: Managing bacterial infections that spread beyond the respiratory tract, such as septicemia or mastitis.
• Preventive Use: In high-risk environments, such as crowded feedlots, to reduce the incidence of bacterial outbreaks.

However, it is important to note that the product should not be used in animals with known hypersensitivity to beta-lactam antibiotics. Adverse reactions may include transient local reactions at the injection site or allergic responses.

Technical Specifications

Parameter	Details
Active Ingredient	Amoxicillin (150 mg/ml)
Formulation	Injectable solution
Administration Route	Intramuscular
Cmax (Cattle)	3.45 µg/ml at 2.45 hours
Cmax (Pigs)	3.54 µg/ml at 2 hours
Metabolism	Hydrolysis in the liver to penicilloic acid (20%)
Excretion	70% via kidneys, 10% via biliary route, 20% via milk
Withdrawal Period	28 days (meat), 4 hours (milk)
Storage	Sealed, protected from light, out of reach of children
Packaging	100 ml/bottle
Shelf Life	3 years

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reputable manufacturer of veterinary pharmaceuticals, dedicated to providing high-quality solutions for animal health. The company's commitment to innovation and compliance with international standards ensures that its products meet the needs of modern livestock management. As highlighted in NIST (National Institute of Standards and Technology) research on pharmaceutical standards, rigorous quality control is essential for effective veterinary treatments.

With a focus on pharmaceutical precision, Shijiazhuang Shimu Pharmaceutical Co., Ltd. adheres to strict manufacturing practices, ensuring the safety and efficacy of its Amoxicillin Injection. The company's products are designed to align with global veterinary guidelines, making them a trusted choice for farmers and veterinarians worldwide.

Authoritative Citations and References

The information provided in this article is supported by authoritative sources, including NIST, which emphasizes the importance of standardized pharmaceutical research and development. According to NIST's guidelines on pharmacokinetic studies, accurate measurement of drug concentrations and distribution is critical for ensuring therapeutic outcomes in veterinary medicine.

For further details on Amoxicillin Injection, visit the product page or explore Shijiazhuang Shimu Pharmaceutical Co., Ltd.'s comprehensive range of veterinary solutions.

Conclusion

Amoxicillin Injection by Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reliable and effective treatment for bacterial infections in cattle and pigs. Its broad-spectrum activity, favorable pharmacokinetic profile, and adherence to safety standards make it a valuable tool in veterinary medicine. By leveraging the expertise of industry leaders and referencing authoritative sources like NIST, this article underscores the importance of evidence-based pharmaceutical solutions for animal health.

References

• National Institute of Standards and Technology (NIST) – Standards for Pharmaceutical Research
• Amoxicillin Injection Product Page
• Shijiazhuang Shimu Pharmaceutical Co., Ltd.