Amoxicillin Injection-Veterinary Use|Broad-Spectrum Antibiotic

Amoxicillin Injection, a critical tool in veterinary medicine, is a broad-spectrum antibiotic derived from the amino-penicillin family. Developed by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this medication is designed to combat a wide range of bacterial infections in livestock, particularly in cattle and pigs. This article provides an in-depth analysis of its pharmacokinetic properties, advantages, technical specifications, and applications, while emphasizing its role in modern veterinary practices.

Product Overview

Amoxicillin Injection is a semisynthetic penicillin antibiotic with potent activity against both Gram-positive and Gram-negative bacteria. It is formulated as a sterile solution for intramuscular administration, ensuring rapid systemic absorption and effective therapeutic outcomes. The product is specifically tailored for veterinary use, addressing bacterial infections in cattle and pigs, which are common in agricultural settings.

Veterinary Amoxicillin Injection is a trusted solution for treating respiratory diseases caused by pathogens such as Mannheimia haemolytica and Pasteurella multocida. Its efficacy, combined with a favorable safety profile, makes it a preferred choice among veterinarians and livestock producers. The product is available in a 100ml bottle, with a shelf life of 3 years when stored properly.

Pharmacokinetic Properties

Understanding the pharmacokinetic profile of Amoxicillin Injection is essential for optimizing its therapeutic use. Here’s a detailed breakdown of its behavior in the body:

• Peak Concentration (Cmax): In cattle, the maximum plasma concentration (3.45 µg/ml) is achieved 2.45 hours post-intramuscular administration. In pigs, Cmax (3.54 µg/ml) is reached within 2 hours.
• Distribution: Amoxicillin distributes primarily to the extracellular compartment, facilitated by its low plasma protein binding (17%). It achieves similar concentrations in pulmonary, pleural, and bronchial tissues as in plasma, with diffusion into pleural, synovial, and lymphatic tissues.
• Metabolism: The drug is metabolized in the liver via hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20% of the original compound).
• Excretion: Amoxicillin is predominantly excreted via the kidneys in its active form, with secondary elimination through the biliary route and milk.

Advantages of Amoxicillin Injection

Amoxicillin Injection offers several advantages that make it a cornerstone of veterinary antibiotic therapy:

• Broad-Spectrum Activity: Effective against both Gram-positive and Gram-negative bacteria, including key pathogens in respiratory infections.
• Time-Dependent Efficacy: Its mechanism of action is optimized with consistent drug concentrations, ensuring prolonged bacterial suppression.
• Fast Onset of Action: Rapid absorption and distribution allow for quick therapeutic effects, critical in treating acute infections.
• Minimal Side Effects: When used as directed, the risk of adverse reactions is low, with transient local reactions at the injection site being the most common.

Technical Specifications

Parameter	Details
Composition	Each ml contains Amoxicillin 150mg.
Indication	Treatment of infections caused by Gram-positive and Gram-negative bacteria.
Dosage Form	100ml/bottle (sterile solution for intramuscular use).
Shelf Life	3 years when stored under recommended conditions.
Storage Conditions	Seal tightly, protect from light, and keep out of reach of children.
Withdrawal Period	Cattle and pigs: 28 days; Milk: 4 hours.

Applications in Veterinary Medicine

Amoxicillin Injection is widely used in veterinary practice for the following applications:

• Respiratory Infections: Targeting pathogens like Mannheimia haemolytica and Pasteurella multocida in cattle and pigs.
• Systemic Infections: Effective in treating bacterial infections affecting multiple organs, including the lungs, skin, and joints.
• Post-Operative Prophylaxis: Preventing bacterial infections following surgical procedures in livestock.
• Chronic Infections: Managing persistent bacterial infections where long-term antibiotic therapy is required.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals based in China. With a commitment to quality and innovation, the company develops products that meet international standards for safety and efficacy. Their expertise in antibiotic formulations ensures that Amoxicillin Injection is produced under strict quality control measures, adhering to Good Manufacturing Practices (GMP).

The company’s dedication to advancing veterinary healthcare is reflected in its comprehensive product portfolio, which includes antibiotics, vaccines, and other essential medications for livestock. By collaborating with veterinarians and agricultural experts, Shijiazhuang Shimu Pharmaceutical Co., Ltd. continues to play a vital role in improving animal health and productivity.

Important Safety Information

While Amoxicillin Injection is generally safe, certain precautions must be observed:

• Allergies: Do not use in animals with a known hypersensitivity to beta-lactam antibiotics.
• Adverse Reactions: Transient local reactions at the injection site may occur but are typically mild.
• Milk Withdrawal: Milk from treated animals must not be used for human consumption during treatment. A 4-hour withdrawal period is required for milk.
• Storage: Keep the product in a cool, dry place away from direct sunlight.

Conclusion

Amoxicillin Injection is a vital antibiotic in veterinary medicine, offering broad-spectrum efficacy, rapid action, and a favorable safety profile. Its pharmacokinetic properties, coupled with the expertise of Shijiazhuang Shimu Pharmaceutical Co., Ltd., ensure that it remains a reliable solution for treating bacterial infections in livestock. As the agricultural sector continues to evolve, the role of antibiotics like Amoxicillin Injection in maintaining animal health and food safety will remain indispensable.

References

For further information on pharmaceutical standards and research, refer to the National Institute of Standards and Technology (NIST), a U.S. government agency that develops and promotes measurement standards to support scientific and industrial advancements.