Amoxicillin Injection-Veterinary Use|Broad-Spectrum Antibiotic

Amoxicillin Injection is a broad-spectrum antibiotic developed by Shijiazhuang Shimu Pharmaceutical Co., Ltd., a leading manufacturer of veterinary pharmaceuticals. This product is specifically designed to treat bacterial infections in cattle and pigs, offering a reliable solution for respiratory diseases caused by pathogens such as Mannheimia haemolytica and Pasteurella multocida. With its time-dependent mechanism of action and low plasma protein binding, Amoxicillin Injection ensures effective therapeutic outcomes while minimizing adverse effects. Below, we explore the product features, technical specifications, application scenarios, and company background in detail.

Product Overview

Amoxicillin Injection is a semisynthetic penicillin that belongs to the amino-penicillin family. It is a bactericidal agent that targets both Gram-positive and Gram-negative bacteria by inhibiting the synthesis and repair of bacterial cell walls. This makes it highly effective against a wide range of pathogens, particularly those associated with respiratory infections in livestock. The product is available in a 100ml/bottle packaging, with a shelf life of 3 years when stored properly.

One of the key advantages of Amoxicillin Injection is its rapid absorption and distribution in the body. After intramuscular administration, the drug reaches peak plasma concentrations (Cmax) within 2–2.45 hours in cattle and pigs. Its low plasma protein binding (17%) allows it to diffuse efficiently into tissues such as the pulmonary, pleural, and bronchial tissues, where it exerts its antibacterial effects. This property is particularly beneficial for treating infections in the respiratory system, where high drug concentrations are critical for efficacy.

Technical Specifications

Parameter	Details
Active Ingredient	Amoxicillin 150mg/ml
Indication	Treatment of infections caused by Gram-positive and Gram-negative bacteria
Administration Route	Intramuscular injection
Peak Plasma Concentration (Cmax)	3.45 µg/ml (cattle), 3.54 µg/ml (pigs)
Half-Life	Approximately 1–2 hours (varies by species)
Metabolism	Hydrolysis in the liver to inactive penicilloic acid (20%)
Excretion	Mainly via kidneys; secondary excretion through biliary route and milk
Withdrawal Period	28 days (cattle/pigs), 4 hours (milk)
Storage	Seal, protect from light, and keep out of reach of children

Key Features and Advantages

Amoxicillin Injection offers several advantages that make it a preferred choice for veterinary use:

• Broad-Spectrum Activity: Effective against both Gram-positive and Gram-negative bacteria, including Mannheimia haemolytica and Pasteurella multocida, which are common causes of respiratory infections in cattle and pigs.
• Time-Dependent Action: The drug’s efficacy is closely tied to the duration of exposure to the pathogen, making it ideal for treating infections that require sustained antibacterial activity.
• Low Plasma Protein Binding: Ensures rapid and widespread distribution in the body, allowing the drug to reach target tissues efficiently.
• Minimal Adverse Reactions: While hypersensitivity (allergy) is a potential risk, local reactions at the injection site are usually transient and mild.
• Convenient Packaging: The 100ml/bottle format ensures easy administration and storage, with a long shelf life of 3 years.

Application Scenarios

Amoxicillin Injection is primarily used to treat respiratory infections in cattle and pigs, which are often caused by Mannheimia haemolytica and Pasteurella multocida. These bacteria can lead to conditions such as pneumonia, bronchitis, and septicemia, which are common in intensive farming environments. The drug’s ability to achieve high concentrations in pulmonary and pleural tissues makes it particularly effective for these applications.

In addition to respiratory infections, Amoxicillin Injection can be used to address other bacterial infections in livestock, including those affecting the urinary tract, skin, and soft tissues. However, it is important to note that the drug is not effective against beta-lactamase-producing bacteria, as it is susceptible to degradation by these enzymes. Therefore, it is recommended to use Amoxicillin Injection only when the causative pathogen is known to be susceptible to penicillin derivatives.

For optimal results, the drug should be administered intramuscularly after shaking the bottle well. It is also crucial to observe the withdrawal period of 28 days for meat and 4 hours for milk to ensure that residues do not enter the food supply. Farmers and veterinarians should follow strict protocols to avoid contamination of milk intended for human consumption.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reputable manufacturer of veterinary pharmaceuticals based in China. The company specializes in developing high-quality antibiotics and antimicrobial agents for livestock, with a focus on efficacy, safety, and compliance with international standards. Their commitment to innovation and research has positioned them as a trusted partner for farmers and veterinarians worldwide.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. adheres to Good Manufacturing Practices (GMP) to ensure that their products meet rigorous quality control standards. Their Amoxicillin Injection is formulated to deliver consistent therapeutic outcomes, with a composition of 150mg of amoxicillin per milliliter. The company’s dedication to animal health and sustainable farming practices aligns with global efforts to improve livestock welfare and reduce the spread of antibiotic-resistant bacteria.

Important Considerations

Before using Amoxicillin Injection, it is essential to consider the following:

• Allergies: The product should not be administered to animals with a known allergy to beta-lactam antibiotics.
• Resistance Monitoring: Due to the increasing prevalence of antibiotic resistance, it is crucial to use Amoxicillin Injection only when necessary and under the guidance of a licensed veterinarian.
• Storage: The drug must be stored in a sealed container111, protected from light, and kept out of reach of children.

References and Authoritative Citations

The development and use of antibiotics like Amoxicillin Injection are supported by scientific research and regulatory standards. According to the National Institute of Standards and Technology (NIST), precise measurement standards are critical for ensuring the accuracy, consistency, and safety of pharmaceutical products. These standards help manufacturers like Shijiazhuang Shimu Pharmaceutical Co., Ltd. produce high-quality antibiotics that meet global health requirements.

For further information on the pharmacokinetics and safety of antibiotics, refer to the following NIST resources:

• NIST Official Website
• NIST Publications

Conclusion

Amoxicillin Injection by Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reliable and effective solution for treating bacterial infections in cattle and pigs. With its broad-spectrum activity, rapid absorption, and minimal side effects, it is an essential tool for veterinarians and farmers. The product’s compliance with international standards and adherence to Good Manufacturing Practices (GMP) further underscore its quality and safety.

For more details about Amoxicillin Injection, including its applications, specifications, and usage guidelines, visit the official product page. To learn more about Shijiazhuang Shimu Pharmaceutical Co., Ltd. and their commitment to veterinary healthcare, explore their company website.

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