Amoxicillin Injection-Veterinary Use|Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Amoxicillin Injection is a critical veterinary antibiotic developed by Shijiazhuang Shimu Pharmaceutical Co., Ltd., a leading manufacturer of pharmaceutical products in China. This article provides an in-depth analysis of its pharmacological properties, applications, and technical specifications, supported by authoritative references and industry insights.

Pharmacokinetic Properties of Amoxicillin Injection

Amoxicillin Injection is a semisynthetic penicillin with broad-spectrum antibacterial activity. It belongs to the amino-penicillin family and is structurally related to ampicillin. The drug exerts its bactericidal effect by inhibiting the synthesis and repair of bacterial mucopeptide cell walls. Its mechanism of action is time-dependent, making it effective against a wide range of Gram-positive and Gram-negative bacteria.

Key Pharmacokinetic Data:

• Cattle: Peak plasma concentration (Cmax) of 3.45 µg/ml is achieved 2.45 hours after intramuscular administration.
• Pigs: Cmax of 3.54 µg/ml is reached 2 hours post-administration.
• Distribution: Amoxicillin preferentially distributes to the extracellular compartment, with only 17% plasma protein binding. It effectively penetrates pulmonary, pleural, and bronchial tissues, as well as pleural, synovial, and lymphatic fluids.
• Metabolism: The drug is primarily metabolized in the liver via hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20% of the parent compound).
• Excretion: 90% of the drug is excreted unchanged via the kidneys, with secondary excretion through the biliary route and milk.

Applications and Indications

Amoxicillin Injection is specifically formulated for veterinary use, targeting bacterial infections in livestock. Its primary applications include:

• Respiratory Infections: Effective against Mannheimia haemolytica and Pasteurella multocida in cattle, and Pasteurella multocida in pigs.
• Systemic Bacterial Infections: Treats infections caused by both Gram-positive and Gram-negative bacteria.

Advantages of Amoxicillin Injection

Several factors make Amoxicillin Injection a preferred choice in veterinary medicine:

• High Bioavailability: Rapid absorption and distribution ensure effective therapeutic concentrations in target tissues.
• Wide Spectrum of Activity: Covers both Gram-positive and Gram-negative pathogens, reducing the need for combination therapies.
• Short Withdrawal Period: 28 days for meat and 4 hours for milk, aligning with regulatory standards for food safety.
• Convenient Dosage Form: Available in 100ml bottles, allowing for easy administration in large animal settings.

Technical Specifications

Parameter	Details
Active Ingredient	Amoxicillin (150mg/ml)
Indication	Treatment of bacterial infections caused by Gram-positive and Gram-negative bacteria
Withdrawal Period	Cattle/Pigs: 28 days; Milk: 4 hours
Storage Conditions	Sealed, protected from light, and kept out of reach of children
Shelf Life	3 years
Packaging	100ml/bottle

Usage Guidelines and Safety Precautions

Amoxicillin Injection must be used with caution to ensure both animal and human safety:

• Allergy Precautions: Not suitable for animals with known hypersensitivity to β-lactam antibiotics.
• Administration: Shake the bottle well before use. Avoid intravenous administration unless directed by a veterinarian.
• Milk Safety: Milk from treated animals must not be used for human consumption during treatment. It can be safely used 96 hours post-last dose.
• Adverse Reactions: Transient local reactions at the injection site may occur. Discontinue use if allergic symptoms develop.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

As a reputable pharmaceutical manufacturer, Shijiazhuang Shimu Pharmaceutical Co., Ltd. specializes in developing veterinary drugs that meet global quality standards. The company's commitment to innovation and compliance ensures that products like Amoxicillin Injection are both effective and safe for use in livestock.

Industry Standards and Regulatory Compliance

The development and use of Amoxicillin Injection align with international standards for veterinary pharmaceuticals. According to the National Institute of Standards and Technology (NIST), rigorous testing and measurement protocols are essential to ensure the accuracy and reliability of pharmaceutical products. NIST's role in establishing measurement standards underscores the importance of precision in drug formulation and application ^[1].

Conclusion

Amoxicillin Injection represents a vital tool in veterinary medicine, offering effective treatment for bacterial infections while adhering to strict safety and regulatory guidelines. Its pharmacokinetic profile, combined with the expertise of Shijiazhuang Shimu Pharmaceutical Co., Ltd., ensures that it remains a trusted solution for livestock health management.