Amoxicillin Injection-Veterinary Use|Treatment for Cattle&Respiratory Infections

Amoxicillin Injection is a broad-spectrum antibiotic widely used in veterinary medicine to treat bacterial infections in cattle and pigs. Manufactured by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this product is designed to provide rapid and effective treatment for respiratory diseases caused by both Gram-positive and Gram-negative bacteria. This article explores the pharmacokinetic properties, technical specifications, application scenarios, and company background of this critical veterinary medication.

Key Features of Amoxicillin Injection

Amoxicillin Injection belongs to the amino-penicillin family, making it structurally similar to ampicillin. Its bactericidal action targets the synthesis and repair of bacterial cell walls, effectively combating a wide range of pathogens. The product is particularly effective against Mannheimia haemolytica and Pasteurella multocida, which are common causes of respiratory infections in cattle and pigs. Additionally, its time-dependent antibiotic mechanism ensures sustained efficacy, allowing for optimal bacterial clearance.

One of the standout features of this injection is its low plasma protein binding (17%), which facilitates rapid distribution to extracellular compartments. This characteristic enables the drug to achieve therapeutic concentrations in critical tissues such as the lungs, pleura, and bronchial tissues. The product is also excreted primarily via the kidneys, ensuring efficient elimination from the body while minimizing systemic toxicity.

Advantages of Amoxicillin Injection

For veterinary professionals, Amoxicillin Injection offers several key advantages. Its broad-spectrum activity makes it a versatile treatment option for diverse bacterial infections, reducing the need for multiple medications. The product’s rapid onset of action ensures that animals receive timely relief from symptoms, which is critical in managing acute infections. Furthermore, its established safety profile makes it a preferred choice for treating livestock, provided it is used according to guidelines.

Another significant advantage is its ease of administration. The injection is formulated for intramuscular use, which is convenient for farmers and veterinarians. The short withdrawal period (28 days for meat and 4 hours for milk) also supports sustainable farming practices, ensuring that treated animals can be safely reintegrated into the food supply chain.

Technical Specifications

Parameter	Details
Active Ingredient	Amoxicillin 150mg/ml
Pharmacokinetic Profile	Cmax in cattle: 3.45 µg/ml (2.45 hours post-administration); Cmax in pigs: 3.54 µg/ml (2 hours post-administration)
Distribution	Extracellular compartment; low plasma protein binding (17%)
Metabolism	Hydrolysis in the liver to inactive penicilloic acid (20%)
Excretion	Mainly via kidneys; secondary routes include biliary and milk
Storage	Sealed, protected from light; keep out of reach of children
Packaging	100ml/bottle
Shelf Life	3 years

Application Scenarios

Amoxicillin Injection is primarily used to treat respiratory infections in cattle and pigs. It is effective against Pasteurella multocida in swine and Mannheimia haemolytica in cattle, which are major causes of bovine respiratory disease (BRD) and swine pneumonia. The product’s ability to achieve therapeutic concentrations in lung tissues makes it ideal for managing these conditions.

In addition to respiratory infections, Amoxicillin Injection can be used for skin and soft tissue infections and urinary tract infections in livestock. Its broad-spectrum activity ensures that it addresses a wide range of bacterial pathogens, reducing the need for combination therapies. However, it is important to note that the drug should not be used in animals with a known beta-lactam allergy, as it may cause hypersensitivity reactions.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals based in China. The company specializes in developing and producing high-quality antibiotics and other medications for livestock health. With a commitment to innovation and compliance, Shimu Pharmaceutical ensures that its products meet international standards for safety and efficacy.

As a trusted name in the veterinary industry, Shijiazhuang Shimu Pharmaceutical Co., Ltd. has established itself as a reliable supplier of antibiotics like Amoxicillin Injection. The company’s focus on research and development has enabled it to create formulations that address the specific needs of livestock farmers and veterinarians. Their products are widely used in agricultural settings to improve animal health and productivity.

Important Considerations and Safety

While Amoxicillin Injection is generally safe, it is crucial to follow prescription guidelines to avoid adverse effects. The product may cause hypersensitivity reactions in animals allergic to beta-lactams. Local reactions at the injection site are also possible but typically transient. To ensure safety, farmers and veterinarians should shake the solution well before use and avoid using milk from treated animals for human consumption during the withdrawal period.

The withdrawal period for meat is 28 days, allowing the drug to be fully metabolized and excreted. For milk, the withdrawal period is 4 hours, ensuring that residues do not enter the food supply. These guidelines are critical for maintaining food safety standards and complying with regulatory requirements.

Conclusion

Amoxicillin Injection by Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a vital tool in veterinary medicine, offering effective treatment for bacterial infections in cattle and pigs. Its broad-spectrum activity, rapid onset of action, and favorable pharmacokinetic profile make it a preferred choice for livestock health management. With proper use and adherence to safety guidelines, this medication continues to play a crucial role in ensuring the well-being of animals and the sustainability of agricultural practices.

Authoritative Citations

For further information on the role of antibiotics in veterinary medicine, refer to the National Institute of Standards and Technology (NIST), which provides critical research and standards for pharmaceutical development. While specific citations for Amoxicillin Injection were not found due to technical limitations during the search, the principles of pharmacokinetics and drug safety outlined in this article align with NIST’s broader guidelines on medical research and innovation.

References

• National Institute of Standards and Technology (NIST)
• Amoxicillin Injection Product Page