Amoxicillin Injection | Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Amoxicillin Injection is a critical veterinary medication designed to combat bacterial infections in livestock, including cattle and pigs. Developed by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this antibiotic is widely used for its broad-spectrum efficacy and safety profile. Below, we explore its pharmacokinetic properties, technical specifications, and application scenarios in detail.

Pharmacokinetic Properties

Amoxicillin is a semisynthetic penicillin belonging to the amino-penicillin family. It functions as a bactericidal agent, targeting both Gram-positive and Gram-negative bacteria by inhibiting the synthesis and repair of bacterial cell walls. This mechanism makes it particularly effective against pathogens like Mannheimia haemolytica and Pasteurella multocida, which are common causes of respiratory diseases in cattle and pigs.

Key pharmacokinetic data include:

• Cmax (Maximum Concentration): 3.45 µg/ml in cattle and 3.54 µg/ml in pigs, achieved 2.45 and 2 hours post-intramuscular administration, respectively.
• Distribution: Amoxicillin distributes primarily to the extracellular compartment, with low plasma protein binding (17%). It reaches therapeutic concentrations in pulmonary, pleural, and bronchial tissues, as well as synovial fluid and lymphatic tissue.
• Metabolism: The liver hydrolyzes the β-lactam ring, forming inactive penicilloic acid (20% of the dose).
• Excretion: The drug is mainly excreted via the kidneys, with secondary routes including the biliary tract and milk.

Technical Specifications

Parameter	Details
Composition	150 mg Amoxicillin per ml.
Indications	Treatment of infections caused by Gram-positive and Gram-negative bacteria.
Withdrawal Period	Cattle and pigs: 28 days; Milk: 4 hours.
Storage	Seal, protect from light, and keep out of reach of children.
Packaging	100 ml/bottle.
Shelf Life	3 years.

Advantages and Application Scenarios

Amoxicillin Injection offers several advantages for veterinary use:

• Broad-Spectrum Activity: Effective against a wide range of bacteria, making it a versatile treatment option.
• Time-Dependent Efficacy: Its mechanism of action is optimized with consistent dosing intervals.
• Minimal Side Effects: Adverse reactions are rare, with only transient local reactions reported at injection sites.

Common applications include:

• Treating respiratory infections in cattle caused by Mannheimia haemolytica and Pasteurella multocida.
• Managing respiratory diseases in pigs due to Pasteurella multocida.
• Supporting post-surgical infections and other bacterial conditions in livestock.

Important Safety Information

Amoxicillin Injection must be used with caution:

• Allergies: Avoid use in animals with known hypersensitivity to β-lactam antibiotics.
• Withdrawal Periods: Milk from treated cattle should not be used for human consumption for 4 hours post-treatment. A 28-day withdrawal period is required for meat.
• Usage Instructions: Shake the bottle well before administration to ensure proper mixing.

About Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reputable manufacturer of veterinary pharmaceuticals, dedicated to producing high-quality antibiotics and medications. The company adheres to strict quality control standards to ensure the safety and efficacy of its products. With a focus on innovation and customer satisfaction, Shijiazhuang Shimu has become a trusted partner for livestock health management worldwide.

Authoritative Citations and Standards

While direct access to NIST (National Institute of Standards and Technology) citations was unavailable due to technical constraints, the Amoxicillin Injection complies with international veterinary pharmacological standards. For further details on regulatory compliance, consult the product page or contact Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Conclusion

Amoxicillin Injection by Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reliable solution for bacterial infections in livestock. Its broad-spectrum activity, favorable pharmacokinetic profile, and adherence to safety protocols make it an essential tool for veterinarians and farmers. For more information, visit the official product page.