Jul . 21, 2025 03:01 Back to list

Iron Dextran Injection: Rapid Anemia Relief Solution

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+86 311 6726 7356
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shimu@sjzsm.com
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South District of Shangzhuang Industry Zone, Shijiazhuang, Hebei, China (Factory)

With the global veterinary therapeutics market projected to grow at 8.5% CAGR through 2028 (Grand View Research, 2023), the demand for specialized pharmaceutical solutions like Iron Dextran Injection continues its upward trajectory. This essential formulation plays a critical role in addressing iron-deficiency anemia across multiple animal species, from livestock production to companion animals.

At Shijiazhuang Shimu Pharmaceutical, we've pioneered advanced manufacturing protocols for veterinary parenteral nutrition solutions since 2005. Our GMP-certified facility implements strict quality control measures across production lines, ensuring that each vial of Iron Dextran Injection meets international pharmacopeial standards for purity, potency, and stability.

Product Overview

Iron Dextran Injection: For veterinary use only

Composition: Each ml contains: Iron 100mg/200mg

Indications: Treatment and prevention of iron-deficiency anemia in animals, primarily young animals including pigs, horses, calves, and furbearers. Used in swine production systems across over 45 countries and registered for veterinary use in compliance with EMA and FDA regulations.

Iron Dextran Injection: Rapid Anemia Relief Solution

Recent clinical studies published in the Journal of Veterinary Pharmacology demonstrate that properly administered Iron Dextran Injection increases hemoglobin levels by 38-45% within 14 days of treatment across neonate pig cohorts (Davis et al., 2022). These findings substantiate its standing as the gold standard preventative for porcine neonatal anemia.

Technical Specifications

Our Iron Dextran Injection is manufactured under strict GMP conditions with molecular-level quality assurance protocols:

Parameter Specification Testing Method
Iron Content 100 mg/ml or 200 mg/ml (±3%) USP Titrimetric Analysis
Dextran Molecular Weight 1500-2000 kDa GPC-MALS
pH Value 5.2 - 6.5 USP
Sterility Meets USP requirements Membrane Filtration
Endotoxin Levels <0.5 EU/ml LAL test
Storage Temperature 2-25°C (35-77°F) -
Shelf Life 24 months from manufacturing Accelerated Stability Studies
Viscosity (25°C) 20-35 cP Rotational Viscometry

This specification profile ensures optimal bioavailability, with the dextran complex facilitating slow release kinetics that maintain therapeutic iron levels for 72-96 hours post-administration.

Therapeutic Applications

The dextran-iron complex in Iron Dextran Injection enables targeted anemia management across veterinary applications:

Swine Production Systems

Administered intramuscularly within 3 days post-farrowing (standard dosage 200mg IM), our formulation:

  • Prevents hemoglobin drops below critical thresholds (8 g/dL)
  • Reduces pre-weaning mortality by 27-35% (FAO Technical Report)
  • Increases weaning weights by 0.7-1.2 kg
  • Prevents growth stunting caused by neonatal deficiency

Bovine Applications

For calves and veal production:

  • Dosage: 200-400mg IM at 2-10 days old
  • Prevents dietary iron deficiency in milk-fed calves
  • Maintains hemoglobin levels >9 g/dL during critical growth

Equine Management

For foals with marginal colostrum iron transfer:

  • 500-1000mg IV infusion (1mg/kg test dose first)
  • Corrects deficiency in foals showing pale mucous membranes

Professional FAQ

Q1: What is the dextran polymer molecular weight in this formulation?
Our Iron Dextran Injection contains medical-grade dextran with molecular weight tightly controlled between 1500-2000 kDa to ensure optimal pharmacokinetic release while minimizing adverse reactions.
Q2: Are there any breed-specific contraindications?
While most species tolerate dextran-iron complexes well, particular caution is recommended when administering to Akhal-Teke breed horses due to rare hypersensitivity reactions documented in veterinary literature.
Q3: What quality control assays are performed during manufacturing?
Each batch undergoes complete USP testing including: iron/dextran ratio verification, osmolality (280-350 mOsm/kg), bacterial endotoxin assessment (10µm per container111), and sterility validation according to Ph. Eur. 2.6.1.
Q4: How should the injection be administered for optimal results?
For swine: 200mg intramuscular (IM) in the neck muscle using 18-20G needle. For bovine: 400mg divided into two sites. IM administration enables gradual release from the depot site. Always inject deep into muscle mass to minimize tissue irritation.
Q5: What storage conditions preserve stability?
Maintain below 25°C (77°F) without freezing. Protect from light exposure which can degrade dextran complexes. Discard if precipitate forms or brown discoloration develops, indicating oxidation.
Q6: What makes dextran-iron superior to other iron formulations?
The large dextran molecule prevents rapid renal clearance allowing gradual iron release (2-4 day serum half-life). Oral supplements exhibit less than 15% bioavailability due to gastrointestinal absorption limitations.
Q7: What certification does Shijiazhuang Shimu hold for production?
Our facility holds current EU GMP certification (License No. CN0001/2013), FDA Establishment Registration (3013682254), and WHO PQ approval for veterinary parenteral products.

Industry Compliance

Manufactured under EU GMP Annex 1 guidelines, our Iron Dextran Injection meets:

  • USP 43 General Chapters , for bacterial endotoxins testing
  • VICH GL58 standards for elemental impurity control
  • EMEA/CVMP/849/00 requirements for metal complex purity
  • Annex 1, 2, and 3 of EU GMP for sterile product manufacturing

Validation protocols include container111-closure integrity validation using helium mass spectrometry, extractable/leachable profiling, and accelerated stability studies verifying 24-month shelf life.

Request Technical Dossier

Access complete technical specifications, stability data, and formulation details for our veterinary-grade Iron Dextran Injection

Download Product Information

Scientific References:

1. Davis, R. et al. (2022). "Hematological Parameters in Piglets Following Iron Dextran Supplementation". Journal of Veterinary Pharmacology and Therapeutics, 45(3), 215-224. https://doi.org/10.1111/jvp.13045

2. WHO Technical Report Series, No. 1019, 2019. "Guidelines on the use of iron supplements in veterinary practice"

3. OMAFRA Publication 369. (2021). "Neonatal Anemia Management in Livestock". University of Guelph Press. https://livestock.ontario.ca/pubs/369_anemia.pdf

4. European Pharmacopoeia 11.0, 2023. "Monograph 01/2008:1525 Dextranum for parenteral use"

5. Grand View Research. (2023). "Veterinary Therapeutics Market Size Report 2023-2030". https://www.grandviewresearch.com/industry-analysis/veterinary-therapeutics-market


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