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Amoxicillin

Amoxicillin

Amoxicillin

Amoxicillin is a moderate spectrum antibiotic that inhibits the growth of bacteria by interfering with the formation of the bacterial cell wall and is used to treat a variety of susceptible infections.

 

Amoxicillin picture

 

Summary

  • Used for: Infections of respiratory system, urinary tract, skin, gastrointestinal systems and Lyme borreliosis
  • Other names: Aminopenicillin
  • Species: Dogs, cats, ferrets, hedgehogs, birds, reptiles
  • Drug type: Antibiotic
  • Pregnancy and lactation: Not established
  • Side effects: Allergic reaction, loss of appetite, drooling, vomiting, nausea, diarrhea
  • FDA approved: Yes

General description

Amoxicillin is a moderate spectrum antibiotic that can be used to treat a variety of infections in many different species. Both gram-positive and gram-negative bacterial species causing infection can be susceptible to amoxicillin. It is not effective against viral or parasitic infections.

A prescription from your veterinarian is needed for purchase.

Uses

Respiratory infection, urinary tract infection, bacterial skin infection, gastrointestinal infections, Lyme borreliosis

How it works

Amoxicillin inhibits the formation of bacterial cell walls, preventing bacterial formation. Because of its effect on bacteria cell walls, amoxicillin can change the bacterial population normally found in an animal’s intestinal tract, leading to gastrointestinal side effects.

Dosage

Dogs: 11-22 milligrams per kilogram by mouth every 8-12 hours; Cats: 11-22 milligrams per kilogram by mouth every 8-24 hours; Ferrets: 20 milligrams per kilogram by mouth every 12 hours; Hedgehogs: 15 milligrams per kilogram by mouth every 12 hours; Birds: 100-125 milligrams per kilogram by mouth every 8-12 hours; Reptiles:22 milligrams per kilogram by mouth every 12-24 hours

Amoxicillin Injection

Forms

Tablets for oral use are available in 50, 100, 125, 150, 200, 250, 400, 500, and 875 milligram sizes. Oral suspension for veterinary use is available in 50 milligrams per milliliter (after reconstitution) in 15 or 30 milliliter bottles.

Storage information & handling

Tablets should be stored in a tightly sealed container at room temperature. Amoxicillin powder for liquid suspension can be stored in a tightly sealed container at room temperature until it is reconstituted, after which it requires refrigeration and use within 14 days.

What results can I expect?

With correct administration, the susceptible infection should resolve.

Missed dosage

Give the missed dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give two doses at once.

Overdose / acute toxicity:

Acute oral amoxicillin overdoses are unlikely to cause significant problems other than gastrointestinal distress. Hypersensitivity reactions can occur in patients who are sensitive to penicillin, and symptoms include labored breathing, hives, and facial swelling. An allergic reaction is a medical emergency, and veterinary treatment should be sought immediately should one occur.

Side effects

  • Hypersensitivity/allergic reaction (hives, facial swelling, labored breathing)
  • Loss of appetite
  • Nausea
  • Drooling
  • Vomiting
  • Diarrhea

Contraindications

  • Patients with a known sensitivity or allergy to the drug
  • Rabbits, guinea pigs, chinchillas, and hamsters can develop severe enterocolitis
  • Patients with septicemia, shock, or other grave illness should not be given oral amoxicillin

Drug interactions

Amoxicillin can interact with bacteriostatic antimicrobials (chloramphenicol, erythromycin, tetracyclines, macrolides, and sulfonamides), methotrexate, and probenecid.

Precaution

Avoid use in rabbits, guinea pigs, chincillas, hamsters, and similar species, as well as individual animals with known sensitivity to amoxicillin. The safety of amoxicillin has not been evaluated in pregnant and lactating animals.

Laboratory considerations

Amoxicillin can cause false positives with urine glucose determinations. Serum concentration of aminoglycosides can be falsely decreased.


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