Amoxicillin Injection for Cattle & Pigs - Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Amoxicillin Injection is a critical veterinary medication designed to combat bacterial infections in livestock, particularly in cattle and pigs. Developed by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this product is a semisynthetic penicillin with broad-spectrum activity against both Gram-positive and Gram-negative bacteria. This article provides an in-depth analysis of its pharmacokinetic properties, technical specifications, application scenarios, and the company's commitment to veterinary healthcare.

Product Overview

Amoxicillin Injection is a bactericidal antibiotic derived from the amino-penicillin family, closely related to ampicillin. It is specifically formulated for use in veterinary medicine to treat infections caused by susceptible microorganisms. The product is available in a 100ml bottle, with each milliliter containing 150mg of amoxicillin. Its primary indication includes respiratory infections in cattle and pigs, such as those caused by Mannheimia haemolytica and Pasteurella multocida.

Pharmacokinetic Properties

Amoxicillin Injection exhibits favorable pharmacokinetic characteristics that ensure effective therapeutic outcomes. After intramuscular administration, the drug reaches peak plasma concentrations (Cmax) in cattle within 2.45 hours and in pigs within 2 hours. The Cmax values are 3.45 µg/ml for cattle and 3.54 µg/ml for pigs, demonstrating rapid absorption.

The drug is predominantly distributed in the extracellular compartment due to its low plasma protein binding (17%). It achieves therapeutic concentrations in critical tissues such as the lungs, pleura, and bronchial tissues, making it highly effective against respiratory pathogens. Amoxicillin also diffuses into pleural, synovial, and lymphatic tissues, further enhancing its efficacy.

Metabolism occurs primarily in the liver via hydrolysis of the β-lactam ring, resulting in the formation of inactive penicilloic acid (20% of the administered dose). The majority of the drug is excreted unchanged through the kidneys, with secondary elimination via the biliary route and milk. This excretion profile ensures prolonged therapeutic activity in target species.

Technical Specifications

Parameter	Details
Active Ingredient	Amoxicillin (150mg/ml)
Formulation	Injectable solution
Indication	Treatment of bacterial infections in cattle and pigs
Administration Route	Intramuscular
Withdrawal Period	Cattle and pigs: 28 days; Milk: 4 hours
Storage	Seal, protect from light, and keep out of reach of children
Shelf Life	3 years

Application Scenarios

Amoxicillin Injection is widely used in veterinary medicine to address bacterial infections in livestock. Its broad-spectrum activity makes it suitable for treating respiratory diseases, which are common in cattle and pigs. For instance, it is effective against Mannheimia haemolytica in cattle and Pasteurella multocida in pigs. The drug's ability to penetrate tissues and fluids ensures that it reaches the site of infection efficiently.

Additionally, Amoxicillin Injection is recommended for managing infections caused by both Gram-positive and Gram-negative bacteria. Its time-dependent mechanism of action means that maintaining therapeutic concentrations over an extended period is crucial for optimal efficacy. This makes it a preferred choice for treating chronic or severe infections in livestock.

Advantages of Amoxicillin Injection

Amoxicillin Injection offers several advantages that make it a reliable choice for veterinarians and livestock producers:

• Broad-Spectrum Activity: Effective against a wide range of bacteria, including both Gram-positive and Gram-negative species.
• Fast Onset of Action: Rapid absorption and distribution ensure quick therapeutic effects.
• Targeted Tissue Penetration: High concentrations in respiratory and inflammatory tissues enhance its efficacy against localized infections.
• Established Safety Profile: While hypersensitivity reactions are possible, the drug is generally well-tolerated when used as directed.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reputable manufacturer of veterinary pharmaceuticals, dedicated to providing high-quality products for livestock health. With a focus on innovation and compliance with international standards, the company ensures that its products meet rigorous quality and safety requirements. Their commitment to research and development has positioned them as a trusted supplier in the veterinary pharmaceutical industry.

For more information about the company's mission and product portfolio, visit their official website: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Important Safety Information

As with all penicillins, Amoxicillin Injection may cause hypersensitivity reactions in animals with a known allergy to beta-lactams. Local reactions at the injection site, such as swelling or redness, may occur but are typically transient. It is crucial to follow the recommended withdrawal periods to ensure the safety of food products derived from treated animals.

Withdrawal Period:

• Cattle and pigs: 28 days
• Milk: 4 hours

Conclusion

Amoxicillin Injection by Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a vital tool in the management of bacterial infections in cattle and pigs. Its pharmacokinetic properties, broad-spectrum activity, and targeted tissue penetration make it an effective treatment option. The product's adherence to strict quality standards ensures reliability and safety for both animals and consumers. For further details, refer to the official product page: Amoxicillin Injection Product Page.

References

While direct citations from NIST were not accessible due to technical limitations, the information provided aligns with established veterinary pharmacology principles. For further reading on antimicrobial standards and research, visit the National Institute of Standards and Technology (NIST): NIST Official Website.