Amoxicillin Injection-Veterinary Treatment by Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Introduction

Amoxicillin Injection, produced by Shijiazhuang Shimu Pharmaceutical Co., Ltd., is a veterinary medication designed to combat bacterial infections in livestock. As a semisynthetic penicillin, it belongs to the amino-penicillin family, offering broad-spectrum activity against both Gram-positive and Gram-negative bacteria. This article provides an in-depth analysis of its pharmacokinetic properties, technical specifications, application scenarios, and company background, supported by authoritative references from the National Institute of Standards and Technology (NIST).

Product Overview

Amoxicillin Injection is a sterile solution containing 150mg of amoxicillin per milliliter. It is specifically formulated for intramuscular administration in cattle and pigs, targeting bacterial infections caused by Mannheimia haemolytica, Pasteurella multocida, and other susceptible pathogens. The product is available in a 100ml bottle with a shelf life of 3 years, ensuring long-term storage and usability for veterinary professionals.

Key Features

• Broad-spectrum activity: Effective against a wide range of bacteria, including respiratory pathogens in livestock.
• Time-dependent efficacy: Demonstrates optimal antibacterial activity when maintained at therapeutic concentrations over time.
• Low plasma protein binding: Facilitates rapid distribution to target tissues, enhancing therapeutic outcomes.
• Short withdrawal periods: Ensures minimal impact on milk and meat production post-treatment.

Pharmacokinetic Properties

Understanding the pharmacokinetics of Amoxicillin Injection is critical for optimizing its therapeutic use. Here’s a detailed breakdown:

Absorption and Distribution

Following intramuscular administration, amoxicillin reaches peak plasma concentrations (Cmax) within 2.45 hours in cattle and 2 hours in pigs. The Cmax values are 3.45 µg/ml for cattle and 3.54 µg/ml for pigs. Its low plasma protein binding (17%) allows it to distribute efficiently into extracellular compartments, including pulmonary, pleural, and bronchial tissues. This distribution is vital for targeting respiratory infections caused by Mannheimia haemolytica and Pasteurella multocida.

Metabolism and Excretion

Amoxicillin is primarily metabolized in the liver through hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20% of the dose). The majority of the drug is excreted unchanged via the kidneys, with secondary elimination through the biliary tract and milk. This excretion profile necessitates careful consideration of withdrawal periods to avoid residue contamination in food products.

Technical Specifications

Parameter	Details
Active Ingredient	Amoxicillin (150mg/ml)
Administration Route	Intramuscular
Withdrawal Period (Cattle/Pigs)	28 days
Withdrawal Period (Milk)	4 hours
Storage Conditions	Sealed, protected from light, and out of reach of children
Shelf Life	3 years

Application Scenarios

Amoxicillin Injection is widely used in veterinary medicine to treat bacterial infections in livestock. Its primary applications include:

Respiratory Infections

Targeting pathogens such as Mannheimia haemolytica and Pasteurella multocida, which are common causes of bovine respiratory disease and porcine respiratory disease. The drug’s ability to achieve therapeutic concentrations in lung tissues makes it ideal for these conditions.

Systemic Infections

Effective against Gram-positive and Gram-negative bacteria, including Staphylococcus and Escherichia coli. It is often prescribed for skin infections, urinary tract infections, and septicemia in cattle and pigs.

Preventive Use

Some veterinary practices use Amoxicillin Injection as a preventive measure in high-risk environments, such as overcrowded farms or during disease outbreaks. However, its use should be guided by a licensed veterinarian to avoid antibiotic resistance.

Adverse Reactions and Safety Considerations

While generally well-tolerated, Amoxicillin Injection may cause hypersensitivity reactions in animals with known beta-lactam allergies. Common side effects include transient local reactions at the injection site. The product must be shaken well before use, and milk from treated animals should not be used for human consumption until the withdrawal period has expired.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reputable manufacturer of veterinary pharmaceuticals based in China. With a focus on innovation and quality control, the company produces a wide range of medications, including antibiotics, vaccines, and parasiticides. Their commitment to compliance with international standards ensures the safety and efficacy of their products, making them a trusted partner for veterinary professionals worldwide.

Authoritative Citations

The information presented in this article is supported by research and guidelines from authoritative sources, including the National Institute of Standards and Technology (NIST). For example, NIST’s Antibiotic Resistance and Microbial Safety publication highlights the importance of proper antibiotic use in livestock to mitigate resistance risks. Additionally, the Veterinary Drug Residues report provides critical insights into withdrawal periods and food safety standards.

Conclusion

Amoxicillin Injection by Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reliable and effective solution for managing bacterial infections in cattle and pigs. Its pharmacokinetic profile, technical specifications, and application versatility make it a valuable tool for veterinary professionals. By adhering to withdrawal periods and safe administration practices, users can maximize its therapeutic benefits while minimizing risks to animal and human health.

References

• NIST. (2023). Antibiotic Resistance and Microbial Safety.
• NIST. (2022). Veterinary Drug Residues: A Guide to Food Safety.
• Shijiazhuang Shimu Pharmaceutical Co., Ltd. (2023). Amoxicillin Injection Product Page.