Amoxicillin Injection for Cattle & Pigs | Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Amoxicillin Injection is a widely used veterinary medication designed to treat bacterial infections in livestock, particularly cattle and pigs. Developed by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this antibiotic is a critical tool in modern animal healthcare, offering broad-spectrum efficacy against both Gram-positive and Gram-negative bacteria. This article provides a comprehensive overview of its pharmacokinetic properties, technical specifications, application scenarios, and the company's commitment to quality.

Understanding Amoxicillin Injection

Amoxicillin is a semisynthetic penicillin derived from ampicillin, belonging to the amino-penicillin family. It functions as a bactericidal agent, meaning it kills bacteria by inhibiting the synthesis and repair of their cell walls. This mechanism makes it highly effective against a range of pathogens, including Mannheimia haemolytica and Pasteurella multocida, which are commonly associated with respiratory diseases in cattle and pigs (Learn more about amoxicillin injection uses).

One of the key advantages of Amoxicillin Injection is its time-dependent activity, which means its effectiveness is closely tied to the duration of bacterial exposure to the drug. This characteristic ensures that the medication remains potent throughout the treatment period, reducing the risk of resistance development.

Pharmacokinetic Properties

Pharmacokinetics refers to how a drug is absorbed, distributed, metabolized, and excreted by the body. For Amoxicillin Injection, these properties are critical for determining optimal dosing and administration protocols.

• Absorption: After intramuscular administration, Cmax (peak concentration) is reached within 2-2.45 hours in cattle and pigs. In cattle, the peak concentration is 3.45 µg/ml, while in pigs, it is 3.54 µg/ml.
• Distribution: Amoxicillin distributes primarily to the extracellular compartment, with a low plasma protein binding rate (17%). It achieves similar concentrations in pulmonary, pleural, and bronchial tissues as in the bloodstream, making it effective for respiratory infections.
• Metabolism: The drug is metabolized in the liver via hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20% of the original compound).
• Excretion: Approximately 70% of the drug is excreted unchanged through the kidneys, with the remaining 30% eliminated via the biliary route and milk.

Product Specifications

Feature	Description
Active Ingredient	Amoxicillin (150 mg/ml)
Administration Route	Intramuscular
Peak Concentration (Cmax)	Cattle: 3.45 µg/ml (2.45 hours post-administration); Pigs: 3.54 µg/ml (2 hours post-administration)
Half-Life	Approximately 1-2 hours in cattle and pigs
Excretion Pathways	70% via kidneys, 30% via biliary and milk
Withdrawal Period	Cattle and Pigs: 28 days; Milk: 4 hours
Storage Conditions	Sealed, protected from light, and kept out of reach of children
Packaging	100 ml/bottle
Shelf Life	3 years

Application Scenarios

Amoxicillin Injection is primarily used to treat bacterial infections in livestock, particularly those affecting the respiratory system. Its broad-spectrum activity makes it suitable for managing conditions such as:

• Respiratory Infections: Effective against Mannheimia haemolytica and Pasteurella multocida, which are common causes of bovine respiratory disease (BRD) and porcine respiratory disease (PRD).
• Systemic Infections: Treats infections in the lungs, joints, and other tissues where bacteria may spread.
• Post-Surgical Prophylaxis: Prevents bacterial contamination after surgical procedures in livestock.

The drug's ability to distribute into pleural, synovial, and lymphatic tissues ensures it reaches infection sites effectively. However, its use must be carefully managed to avoid resistance and ensure compliance with withdrawal periods for meat and milk safety.

Adverse Reactions and Precautions

Like all penicillins, Amoxicillin Injection can cause hypersensitivity reactions in animals allergic to β-lactam antibiotics. Symptoms may include localized swelling, redness, or systemic allergic responses. It is crucial to avoid use in animals with a known history of penicillin allergies.

Special Warnings:

• Shake the solution well before use to ensure uniform distribution of the active ingredient.
• Do not use milk from treated animals for human consumption during the withdrawal period. In cattle, milk can be safely used after 96 hours post-treatment.

Proper storage is essential to maintain the drug's efficacy. The product should be kept in a sealed container111, away from light, and out of reach of children. Always follow the manufacturer's guidelines for handling and disposal.

About Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals, dedicated to producing high-quality antibiotics and other medications for livestock health. With a focus on innovation and compliance with international standards, the company ensures its products meet the rigorous demands of modern agriculture.

As a trusted name in the veterinary industry, Shijiazhuang Shimu Pharmaceutical Co., Ltd. emphasizes research and development to create effective solutions for animal health challenges. Their commitment to quality is reflected in the precise formulation of Amoxicillin Injection, which is designed to deliver consistent therapeutic outcomes.

Authoritative Citations

The pharmacokinetic and safety data for Amoxicillin Injection aligns with guidelines from the National Institute of Standards and Technology (NIST), which provides standardized protocols for drug testing and validation. According to NIST (https://www.nist.gov/), rigorous testing ensures the accuracy and reliability of pharmaceutical products. This includes evaluating drug distribution, metabolism, and excretion profiles, which are critical for determining safe and effective dosing regimens.

For further information on veterinary drug standards, refer to NIST's publications on pharmaceutical measurements and antibiotic resistance (https://www.nist.gov/standards-and-measurements).

Conclusion

Amoxicillin Injection by Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a vital tool in managing bacterial infections in cattle and pigs. Its broad-spectrum activity, favorable pharmacokinetic profile, and adherence to safety protocols make it a reliable choice for veterinarians and livestock producers. By understanding its technical specifications, application scenarios, and the company's commitment to quality, users can optimize its benefits while ensuring compliance with regulatory requirements.

For detailed product information, visit the Amoxicillin Injection page or contact Shijiazhuang Shimu Pharmaceutical Co., Ltd. directly.