Amoxicillin Injection-Veterinary Antibiotic by Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Amoxicillin Injection is a veterinary amoxicillin injection designed to combat bacterial infections in livestock. As a broad-spectrum antibiotic, it is widely used in veterinary medicine to treat respiratory diseases in cattle and pigs. This article explores its pharmacokinetic properties, advantages, technical specifications, application scenarios, and the background of its manufacturer, Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Understanding Amoxicillin Injection

Amoxicillin is a semisynthetic penicillin with a structural similarity to ampicillin. It functions as a bactericidal agent, targeting both Gram-positive and Gram-negative bacteria by inhibiting the synthesis of bacterial cell walls. This mechanism makes it effective against a range of pathogens, including Mannheimia haemolytica and Pasteurella multocida, which are commonly associated with respiratory infections in cattle and pigs.

Pharmacokinetic Properties

The pharmacokinetics of Amoxicillin Injection vary slightly between species. In cattle, the maximum plasma concentration (Cmax) of 3.45 µg/ml is achieved 2.45 hours after intramuscular administration. For pigs, the Cmax of 3.54 µg/ml is reached within 2 hours. The drug distributes primarily to the extracellular compartment, with low plasma protein binding (17%), allowing it to penetrate tissues like the lungs, pleura, and bronchial tissues effectively.

Amoxicillin is metabolized in the liver via hydrolysis of the β-lactam ring, forming inactive penicilloic acid. It is primarily excreted through the kidneys, with secondary routes including the biliary tract and milk. This distribution profile ensures sustained therapeutic levels in target tissues.

Advantages of Amoxicillin Injection

Amoxicillin Injection offers several advantages, making it a preferred choice for veterinary applications. Its broad-spectrum activity against both Gram-positive and Gram-negative bacteria ensures versatility in treating diverse infections. Additionally, its time-dependent efficacy means that maintaining consistent drug concentrations in the bloodstream is critical for optimal results.

The product’s formulation allows for rapid absorption and distribution, minimizing the risk of bacterial resistance. Its low plasma protein binding further enhances its ability to reach infected tissues. These properties make it particularly effective for respiratory infections, where quick action is essential.

Technical Specifications

Parameter	Details
Composition	Each ml contains Amoxicillin 150mg.
Indication	Treatment of infections caused by Gram-positive and Gram-negative bacteria.
Pharmacokinetics	Cmax in cattle: 3.45 µg/ml (2.45h post-administration); Cmax in pigs: 3.54 µg/ml (2h post-administration).
Adverse Reactions	Hypersensitivity (allergy) in animals allergic to β-lactams; transient local reactions at injection sites.
Withdrawal Period	Cattle and pigs: 28 days; Milk: 4 hours.
Storage	Seal and protect from light. Keep out of reach of children.
Packaging	100ml/bottle.
Shelf Life	3 years.

Application Scenarios

Amoxicillin Injection is primarily used to treat respiratory diseases in cattle and pigs, including those caused by Mannheimia haemolytica and Pasteurella multocida. Its ability to penetrate lung and pleural tissues makes it effective for conditions such as pneumonia and bronchitis. The drug’s rapid onset of action ensures that infected animals receive timely treatment, reducing the risk of complications.

Additionally, its low plasma protein binding allows it to achieve therapeutic concentrations in extracellular fluids, making it suitable for infections in the respiratory tract, urinary system, and skin. The product is also used in cases where bacterial resistance to other antibiotics is a concern.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reputable manufacturer of veterinary pharmaceuticals, specializing in antibiotics and other essential medications for livestock. The company is committed to producing high-quality products that meet international standards. Their Amoxicillin Injection is a testament to their dedication to innovation and efficacy in veterinary care.

With a focus on research and development, Shijiazhuang Shimu ensures that their products are formulated to address the specific needs of the agricultural sector. Their commitment to quality control and compliance with regulatory guidelines further solidifies their position as a trusted supplier in the veterinary pharmaceutical industry.

Important Safety Information

Before administering Amoxicillin Injection, it is crucial to ensure that the animal is not allergic to β-lactam antibiotics. Hypersensitivity reactions, though rare, can occur and require immediate veterinary attention. The product should be shaken well before use to ensure uniform distribution of the active ingredient.

For milk production, the withdrawal period is 4 hours, meaning milk from treated animals should not be used for human consumption during this time. The withdrawal period for meat is 28 days, ensuring that residues are eliminated before slaughter.

Conclusion

Amoxicillin Injection by Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reliable and effective solution for treating bacterial infections in livestock. Its broad-spectrum activity, favorable pharmacokinetic profile, and safety record make it a valuable tool in veterinary medicine. By adhering to proper administration guidelines and withdrawal periods, farmers and veterinarians can ensure the health of their animals while maintaining the integrity of the food supply.

References

1. National Institute of Standards and Technology (NIST). (2023). "Standards for Pharmaceutical Measurements." Retrieved from https://www.nist.gov/. NIST provides critical standards and measurements that ensure the accuracy and reliability of pharmaceutical products, including antibiotics like Amoxicillin.

2. Shijiazhuang Shimu Pharmaceutical Co., Ltd. (2023). Amoxicillin Injection Product Page. Retrieved from https://www.skyvetpharm.com/amoxicillin-injection.html.

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