Amoxicillin Injection for Cattle & Pigs | Shimu Pharma

Amoxicillin Injection is a critical veterinary antibiotic designed to combat bacterial infections in livestock, particularly in cattle and pigs. Developed by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this product is widely used for its efficacy against a broad spectrum of pathogens. This article explores its pharmacokinetic properties, technical specifications, application scenarios, and the company's commitment to quality.

Understanding Amoxicillin Injection

Amoxicillin is a semisynthetic penicillin with a structural resemblance to ampicillin. As a bactericidal antibiotic, it targets both Gram-positive and Gram-negative bacteria by inhibiting bacterial cell wall synthesis. Its mechanism of action involves binding to penicillin-binding proteins (PBPs), disrupting the cross-linking of peptidoglycan in the cell wall, ultimately leading to cell lysis.

Key Features of Amoxicillin Injection

The product's features are tailored for veterinary use, ensuring rapid and effective treatment of infections. Notable characteristics include:

• Broad-Spectrum Activity: Effective against pathogens like Mannheimia haemolytica and Pasteurella multocida, which are common in respiratory diseases in cattle and pigs.
• Time-Dependent Efficacy: Its therapeutic effect is maximized when drug concentrations remain above the minimum inhibitory concentration (MIC) for an extended period.
• Low Plasma Protein Binding: Only 17% of the drug binds to plasma proteins, allowing it to distribute widely in tissues.
• Short Withdrawal Period: 28 days for meat and 4 hours for milk, ensuring compliance with food safety regulations.

Technical Specifications

Parameter	Details
Active Ingredient	Amoxicillin 150mg/ml
Administration Route	Intramuscular
Cmax in Cattle	3.45 µg/ml at 2.45 hours
Cmax in Pigs	3.54 µg/ml at 2 hours
Metabolism	Hydrolysis in the liver to penicilloic acid (20%)
Excretion	Primarily via kidneys; secondarily through bile and milk
Storage Conditions	Sealed, protected from light, and out of reach of children
Shelf Life	3 years

Applications in Veterinary Medicine

Amoxicillin Injection is primarily used to treat respiratory infections in cattle and pigs. Its efficacy against Mannheimia haemolytica and Pasteurella multocida makes it a first-line treatment for conditions like bovine respiratory disease (BRD) and swine pneumonia. The drug's ability to penetrate tissues such as the lungs and pleura ensures targeted delivery, reducing the risk of systemic side effects.

Advantages of Shijiazhuang Shimu Pharmaceutical Co., Ltd.

As a leading manufacturer of veterinary pharmaceuticals, Shijiazhuang Shimu Pharmaceutical Co., Ltd. prioritizes quality and innovation. The company adheres to stringent manufacturing standards, ensuring that its products meet global regulatory requirements. Their commitment to research and development has led to the creation of reliable solutions like Amoxicillin Injection, which addresses critical challenges in livestock health.

Important Safety Information

While generally well-tolerated, Amoxicillin Injection may cause adverse reactions in sensitive animals. Key precautions include:

• Allergic Reactions: Avoid use in animals with a known allergy to beta-lactams.
• Local Reactions: Transient injection site reactions may occur but are typically mild.
• Milk Withdrawal: Do not use in dairy cattle during lactation; milk must be discarded for 4 hours post-treatment.

Compliance with Regulatory Standards

Shijiazhuang Shimu Pharmaceutical Co., Ltd. ensures its products align with international veterinary standards. The company's adherence to guidelines from organizations like the National Institute of Standards and Technology (NIST) underscores its dedication to precision and safety. NIST's role in developing measurement standards for pharmaceuticals is critical in validating the efficacy and consistency of products like Amoxicillin Injection.

Conclusion

Amoxicillin Injection by Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a vital tool in veterinary medicine, offering a reliable solution for bacterial infections in cattle and pigs. Its robust pharmacokinetic profile, combined with the company's commitment to quality, ensures effective and safe treatment. For more information, visit the product page or explore the company's website.

References

1. National Institute of Standards and Technology (NIST). https://www.nist.gov/ (Accessed: October 2023). NIST provides critical measurement standards that underpin pharmaceutical research and development.

2. Shijiazhuang Shimu Pharmaceutical Co., Ltd. Product specifications and technical data. https://www.skyvetpharm.com/amoxicillin-injection.html (Accessed: October 2023).