Amoxicillin Injection-Veterinary Use|Broad-Spectrum Antibiotic&Infection Control

Amoxicillin Injection is a critical solution in veterinary medicine, offering broad-spectrum antibacterial properties. Developed by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this product is designed to address bacterial infections in livestock, particularly in cattle and pigs. Below is a comprehensive overview of its features, technical specifications, and applications.

Product Overview

Amoxicillin Injection is a semisynthetic penicillin antibiotic that targets both Gram-positive and Gram-negative bacteria. Its mechanism of action involves inhibiting bacterial cell wall synthesis, making it effective against a wide range of pathogens. The product is available in a 1g/mL concentration, with each milliliter containing 150mg of amoxicillin, as outlined in its product specifications.

Pharmacokinetic Properties

The pharmacokinetic profile of Amoxicillin Injection ensures its efficacy in treating bacterial infections. After intramuscular administration:

• Cattle: Peak plasma concentration (Cmax) of 3.45 µg/mL is achieved within 2.45 hours.
• Pigs: Cmax of 3.54 µg/mL is reached in 2 hours.

The drug distributes primarily to the extracellular compartment, with a low plasma protein binding rate (17%). This allows it to reach tissues such as the lungs, pleura, and bronchial areas effectively. Amoxicillin is metabolized in the liver, forming inactive penicilloic acid, and is excreted via the kidneys, with secondary elimination through the biliary route and milk.

Key Features and Advantages

Amoxicillin Injection offers several advantages for veterinary use:

• Broad-Spectrum Activity: Effective against Mannheimia haemolytica and Pasteurella multocida, common pathogens in bovine and porcine respiratory diseases.
• Time-Dependent Efficacy: Its mechanism aligns with the pharmacokinetic profile, ensuring sustained antibacterial action.
• Convenient Formulation: Available in a 100ml bottle, it provides flexibility for large-scale veterinary applications.
• Short Withdrawal Period: Milk withdrawal is 4 hours, and meat withdrawal is 28 days, ensuring compliance with food safety standards.

Technical Specifications

Parameter	Details
Active Ingredient	Amoxicillin 150mg/mL
Indication	Treatment of bacterial infections caused by Gram-positive and Gram-negative bacteria
Administration Route	Intramuscular
Withdrawal Period (Meat)	28 days
Withdrawal Period (Milk)	4 hours
Storage Conditions	Sealed, protected from light, and out of reach of children
Shelf Life	3 years

Application Scenarios

Amoxicillin Injection is widely used in the treatment of respiratory infections in livestock. Its efficacy against Mannheimia haemolytica and Pasteurella multocida makes it a preferred choice for managing bovine and porcine respiratory diseases. Additionally, it is suitable for treating infections caused by other susceptible bacteria, as detailed in its product documentation.

Adverse Reactions and Warnings

As with all penicillins, Amoxicillin Injection may cause hypersensitivity reactions. It should not be used in animals with a known allergy to beta-lactam antibiotics. Local reactions at the injection site are rare but may occur. Shijiazhuang Shimu Pharmaceutical Co., Ltd. advises shaking the solution well before use and avoiding milk consumption during treatment.

Company Background

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals, dedicated to providing high-quality solutions for animal health. With a focus on innovation and compliance, the company ensures its products meet international standards. Their commitment to research and development has established them as a trusted name in the veterinary industry.

References

For further information on the scientific principles of amoxicillin, refer to the National Institute of Standards and Technology (NIST) website, which provides authoritative resources on pharmaceutical standards and measurements.