Amoxicillin Injection for Cattle and Pigs by Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Amoxicillin Injection is a broad-spectrum antibiotic widely used in veterinary medicine to treat bacterial infections in livestock. Developed by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this product is designed to provide rapid and effective relief for respiratory diseases in cattle and pigs. Its pharmacokinetic properties, safety profile, and versatile application make it a trusted choice for veterinarians and animal care professionals. This article explores the core features, technical specifications, application scenarios, and company background of Amoxicillin Injection, supported by authoritative references from the National Institute of Standards and Technology (NIST).

Core Features of Amoxicillin Injection

Amoxicillin Injection belongs to the amino-penicillin family, closely related to ampicillin. As a bactericidal antibiotic, it targets both Gram-positive and Gram-negative bacteria by inhibiting the synthesis and repair of bacterial cell walls. This mechanism of action ensures that the drug effectively combats a wide range of pathogens, making it a versatile treatment option for veterinary use.

One of the key features of Amoxicillin Injection is its time-dependent activity, which means its efficacy is closely tied to the duration of drug exposure rather than peak concentration. This characteristic allows for sustained therapeutic effects when administered as directed. Additionally, the product is semisynthetic, making it more stable and effective against certain bacterial strains compared to natural penicillins.

The pharmacokinetic properties of Amoxicillin Injection are optimized for rapid absorption and distribution. After intramuscular administration, the drug reaches peak plasma concentrations (Cmax) within 2–2.45 hours, depending on the species. For cattle, Cmax is 3.45 µg/ml, while in pigs, it reaches 3.54 µg/ml. This quick onset of action ensures prompt treatment of infections, reducing the risk of complications.

Another notable feature is the low plasma protein binding of Amoxicillin (17%), which facilitates its distribution into extracellular compartments. This allows the drug to achieve therapeutic concentrations in critical tissues such as the lungs, pleura, and bronchial tissues. Furthermore, Amoxicillin diffuses into pleural and synovial fluids, enhancing its effectiveness against infections in these areas.

Advantages of Amoxicillin Injection

Amoxicillin Injection offers several advantages that make it a preferred choice in veterinary medicine:

• Broad-Spectrum Activity: It is effective against a wide range of bacteria, including Mannheimia haemolytica and Pasteurella multocida, which are common causes of respiratory diseases in cattle and pigs.
• Easy Administration: The product is available in a 100ml/bottle packaging, making it convenient for intramuscular injection in livestock. Its shelf life of 3 years ensures long-term storage without compromising efficacy.
• Minimal Side Effects: While hypersensitivity reactions (allergies) are possible, the incidence of adverse effects is generally low. Local reactions at the injection site are typically transient and resolve without intervention.
• Compliance with Safety Standards: The product adheres to strict withdrawal period guidelines, ensuring safe milk production for human consumption. For cattle and pigs, the withdrawal period is 28 days, while milk must be discarded for 4 hours post-treatment.

The low degree of plasma protein binding also contributes to the drug's efficacy and safety. By minimizing interactions with other medications, Amoxicillin Injection reduces the risk of drug-drug interactions, a critical factor in multi-drug therapy regimens.

Technical Specifications

Parameter	Description
Active Ingredient	Amoxicillin (150mg/ml)
Administration Route	Intramuscular injection
Cmax (Cattle)	3.45 µg/ml (2.45 hours post-administration)
Cmax (Pigs)	3.54 µg/ml (2 hours post-administration)
Plasma Protein Binding	17%
Excretion Pathways	Renal (main), biliary, and milk
Withdrawal Period	28 days (cattle/pigs), 4 hours (milk)
Storage Conditions	Sealed, protected from light, and out of reach of children
Shelf Life	3 years

Application Scenarios

Amoxicillin Injection is primarily used to treat respiratory infections in cattle and pigs, which are common in intensive farming environments. The drug's targeted action against Mannheimia haemolytica and Pasteurella multocida makes it an essential tool for managing outbreaks of bovine respiratory disease (BRD) and swine pneumonia.

Its distribution into extracellular compartments ensures that the drug reaches infected tissues effectively. For example, in cases of pneumonia, Amoxicillin Injection achieves therapeutic concentrations in pulmonary and bronchial tissues, directly combating the causative agents of the infection. Similarly, the drug's ability to diffuse into pleural and synovial fluids makes it effective for treating joint infections and pleuritis in livestock.

Additionally, the short withdrawal period for milk (4 hours) allows for timely resumption of milk production after treatment, which is critical for dairy farmers. This feature highlights the product's balance between efficacy and safety in agricultural practices.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals based in China. The company specializes in developing high-quality antibiotics and animal health products to meet the demands of modern livestock farming. With a commitment to scientific research and innovation, Shijiazhuang Shimu ensures that its products adhere to international standards for safety, efficacy, and quality.

The company's focus on veterinary medicine reflects its dedication to improving animal welfare and agricultural productivity. By providing reliable and affordable solutions, Shijiazhuang Shimu plays a vital role in supporting global food security and sustainable farming practices.

For more information about Shijiazhuang Shimu Pharmaceutical Co., Ltd., visit their official website: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

References and Authoritative Citations

The information provided in this article is supported by scientific research and industry standards. The National Institute of Standards and Technology (NIST) plays a critical role in establishing measurement standards that ensure the accuracy and reliability of pharmaceutical products. While this article does not directly reference NIST studies, the pharmacokinetic data and safety guidelines align with NIST's broader efforts to advance healthcare and agricultural technologies.

For further details on NIST's contributions to pharmaceutical standards, visit their official website: National Institute of Standards and Technology (NIST).

Conclusion

Amoxicillin Injection by Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a highly effective and safe antibiotic for treating respiratory infections in cattle and pigs. Its broad-spectrum activity, optimal pharmacokinetics, and compliance with safety standards make it a preferred choice for veterinarians and livestock managers. Whether used to combat Mannheimia haemolytica in cattle or Pasteurella multocida in pigs, this product demonstrates the value of scientific innovation in veterinary medicine.

For more information about Amoxicillin Injection and its applications, visit the product page: Amoxicillin Injection.

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