Amoxicillin Injection - Shijiazhuang Shimu Pharmaceutical Co., Ltd.|Veterinary Antibiotic,Broad-Spectrum Activity

Amoxicillin Injection is a widely used antibiotic in veterinary medicine, specifically formulated to treat bacterial infections in livestock. Developed by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this product belongs to the amino-penicillin family and is known for its broad-spectrum activity against both Gram-positive and Gram-negative bacteria. This article provides an in-depth analysis of its pharmacokinetic properties, technical specifications, application scenarios, and the company's background, supported by authoritative references.

Product Overview

Amoxicillin Injection is a semisynthetic penicillin designed for intramuscular administration in animals. It is particularly effective against respiratory pathogens such as Mannheimia haemolytica and Pasteurella multocida in cattle and pigs. The product is available in a 100ml bottle with a shelf life of 3 years and a concentration of 150mg/ml. Its formulation ensures rapid absorption and distribution, making it a preferred choice for treating infections in veterinary settings.

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Pharmacokinetic Properties

Understanding the pharmacokinetics of Amoxicillin Injection is critical for optimizing its therapeutic efficacy. After intramuscular administration, the drug reaches peak plasma concentrations (Cmax) within specific timeframes:

• Cattle: Cmax of 3.45 µg/ml is achieved 2.45 hours post-administration.
• Pigs: Cmax of 3.54 µg/ml is reached 2 hours after injection.

The drug is primarily distributed in the extracellular compartment due to its low plasma protein binding (17%). It effectively penetrates tissues such as the lungs, pleura, and bronchial regions, with concentrations comparable to plasma levels. Amoxicillin also diffuses into pleural, synovial, and lymphatic tissues, enhancing its ability to combat localized infections.

Metabolism occurs in the liver via hydrolysis of the β-lactam ring, producing inactive penicilloic acid (20% of the administered dose). Excretion is predominantly renal, with a smaller portion eliminated through the biliary route and milk. This distribution profile ensures sustained antibacterial activity in target tissues.

Technical Specifications

Parameter	Details
Active Ingredient	Amoxicillin (150mg/ml)
Formulation	Injectable Solution
Dosage	150mg/ml (1g per 6.67ml)
Administration Route	Intramuscular
Withdrawal Period	Cattle & Pigs: 28 days | Milk: 4 hours
Storage	Sealed, protected from light, and out of reach of children
Shelf Life	3 years

Application Scenarios

Amoxicillin Injection is specifically indicated for treating bacterial infections in livestock, particularly those caused by susceptible pathogens. Key application scenarios include:

• Respiratory Infections: Effective against Mannheimia haemolytica and Pasteurella multocida in cattle and pigs, which are common causes of bovine respiratory disease (BRD) and swine respiratory syndrome (SRS).
• Soft Tissue Infections: Its ability to penetrate tissues makes it suitable for treating abscesses, wounds, and other localized infections.
• Systemic Infections: Due to its broad-spectrum activity, it is used for septicemia and other systemic bacterial infections in veterinary settings.

For optimal results, the product should be administered under the guidance of a licensed veterinarian, ensuring proper dosage and adherence to withdrawal periods to prevent residues in food products.

Advantages of Amoxicillin Injection

Amoxicillin Injection offers several advantages that make it a preferred choice in veterinary medicine:

• Fast Onset of Action: Rapid absorption and distribution ensure quick therapeutic effects, which is critical in treating acute infections.
• Broad-Spectrum Activity: Effective against a wide range of Gram-positive and Gram-negative bacteria, reducing the need for multiple antibiotics.
• Cost-Effective: The 100ml formulation provides a high volume at a competitive price, making it economical for large-scale livestock operations.
• Minimal Side Effects: While hypersensitivity reactions are possible, the drug is generally well-tolerated, with transient local reactions being rare.

These benefits make Amoxicillin Injection a reliable solution for managing bacterial infections in agricultural settings.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reputable Chinese pharmaceutical company specializing in veterinary medications. With a focus on innovation and quality, the company has established itself as a trusted provider of antibiotics and other veterinary products. Their commitment to research and development ensures that their formulations meet international standards for efficacy and safety.

The company’s Amoxicillin Injection is part of a broader portfolio of veterinary pharmaceuticals designed to address the unique challenges of livestock health. Their products are widely used in China and exported to other regions, reflecting their dedication to improving animal welfare and agricultural productivity.

Important Safety Information

While Amoxicillin Injection is generally safe, users must adhere to the following precautions:

• Allergy Risk: Avoid use in animals with a known hypersensitivity to β-lactam antibiotics. Cross-reactivity with other penicillins is possible.
• Withdrawal Periods: Milk for human consumption must not be used during treatment. Cattle and pigs require a 28-day withdrawal period, while milk must be discarded for 4 hours post-administration.
• Storage: Keep the product in a sealed container111, away from light, and out of reach of children.

For detailed safety instructions, consult the product’s product page.

Authoritative References

The information provided in this article is supported by scientific research and regulatory guidelines. For further details on antibiotic use in veterinary medicine, refer to the following authoritative sources:

• National Institute of Standards and Technology (NIST) – Provides standards for pharmaceutical testing and quality control.
• U.S. Food and Drug Administration (FDA) – Offers guidelines on antibiotic use in animals.

Conclusion

Amoxicillin Injection is a vital tool in veterinary medicine, offering effective treatment for bacterial infections in cattle and pigs. Its favorable pharmacokinetic profile, broad-spectrum activity, and cost-effectiveness make it a preferred choice for livestock producers. Manufactured by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this product exemplifies the company’s commitment to quality and innovation in veterinary care.

For more information on Amoxicillin Injection, visit the product page or explore the company’s website.