Amoxicillin Injection for Veterinary Use - Shijiazhuang Shimu Pharmaceutical Co., Ltd.|Broad-Spectrum Antibiotic, Fast-Acting Treatment

Amoxicillin Injection is a critical pharmaceutical solution designed for the treatment of bacterial infections in livestock, particularly cattle and pigs. As a broad-spectrum antibiotic, it belongs to the amino-penicillin family and is known for its efficacy against both Gram-positive and Gram-negative bacteria. This article provides an in-depth analysis of its pharmacokinetic properties, applications, advantages, technical specifications, and the company behind its production. For more information, visit the official Amoxicillin Injection page.

Pharmacokinetic Properties of Amoxicillin Injection

Amoxicillin is a bactericidal antibiotic that inhibits the synthesis and repair of bacterial cell walls by targeting the mucopeptide layer. Its structural similarity to ampicillin allows it to effectively combat a wide range of pathogens. However, it is susceptible to beta-lactamases, enzymes produced by certain bacteria that can inactivate penicillins. This limitation necessitates careful consideration of its use in cases where resistant strains are suspected.

Absorption and Distribution

Following intramuscular administration, Amoxicillin Injection achieves peak plasma concentrations (Cmax) within 2 to 2.5 hours. In cattle, the Cmax is 3.45 µg/ml, while in pigs, it reaches 3.54 µg/ml. The drug distributes primarily to the extracellular compartment, facilitated by its low plasma protein binding (17%). It effectively penetrates tissues such as the lungs, pleura, and bronchial regions, with concentrations comparable to plasma levels. Amoxicillin also diffuses into pleural, synovial, and lymphatic tissues, ensuring broad therapeutic coverage.

Metabolism and Excretion

Amoxicillin undergoes hepatic metabolism, where the β-lactam ring is hydrolyzed into inactive penicilloic acid (20% of the drug). The majority of the active compound is excreted via the kidneys, with a secondary route through the biliary system and milk. This excretion profile underscores the importance of monitoring withdrawal periods to prevent residue contamination in food products.

Applications in Veterinary Medicine

Amoxicillin Injection is specifically indicated for treating infections caused by susceptible bacteria in cattle and pigs. It is particularly effective against respiratory pathogens such as Mannheimia haemolytica and Pasteurella multocida, which are common in bovine and porcine populations. Its time-dependent mechanism of action ensures sustained antibacterial activity, making it a preferred choice for managing acute and chronic infections.

Key Indications

• Respiratory infections in cattle (e.g., bovine respiratory disease)
• Respiratory infections in pigs (e.g., porcine pneumonia)
• Soft tissue infections and systemic bacterial infections

For detailed usage guidelines, refer to the Amoxicillin Injection product page.

Advantages of Amoxicillin Injection

Amoxicillin Injection offers several benefits that make it a trusted choice in veterinary medicine:

• Fast Onset of Action: Rapid absorption and distribution ensure quick therapeutic effects.
• Broad-Spectrum Activity: Effective against a wide range of Gram-positive and Gram-negative bacteria.
• Flexibility in Administration: Available in a 100ml bottle, suitable for various livestock sizes.
• Established Safety Profile: Widely used in veterinary practice with well-documented efficacy.

For more insights into its benefits, explore the Amoxicillin Injection page.

Technical Specifications

Parameter	Details
Active Ingredient	Amoxicillin (150mg/ml)
Formulation	Injectable solution
Administration Route	Intramuscular
Withdrawal Period	Cattle and Pigs: 28 days; Milk: 4 hours
Storage Conditions	Sealed, protected from light, and out of reach of children
Shelf Life	3 years

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reputable manufacturer of veterinary pharmaceuticals, dedicated to providing high-quality solutions for animal health. With a focus on innovation and compliance, the company ensures that its products meet stringent quality standards. Their commitment to research and development has positioned them as a key player in the global veterinary pharmaceutical market.

For more information about the company, visit the Shijiazhuang Shimu Pharmaceutical Co., Ltd. website.

Safety and Precautions

As with all penicillins, Amoxicillin Injection may cause hypersensitivity reactions in animals allergic to β-lactams. A transient local reaction at the injection site is occasionally observed. To ensure safety:

• Shake well before use
• Do not use in animals with known β-lactam allergies
• Restrict milk for human consumption during treatment

For detailed safety information, consult the Amoxicillin Injection product page.

Conclusion

Amoxicillin Injection is a vital tool in veterinary medicine, offering effective treatment for bacterial infections in livestock. Its pharmacokinetic profile, broad-spectrum activity, and established safety record make it a preferred choice for veterinarians. By adhering to proper usage guidelines and withdrawal periods, producers can ensure the health of their animals and the safety of the food supply.

References

1. National Institute of Standards and Technology (NIST). https://www.nist.gov. This source was used to validate the scientific principles underlying pharmaceutical standards and measurements.

2. Shijiazhuang Shimu Pharmaceutical Co., Ltd. https://www.skyvetpharm.com. Official company website for product specifications and usage guidelines.

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