Amoxicillin Injection-Veterinary Use|Broad-Spectrum Antibiotic&Veterinary Medicine

Introduction

Amoxicillin Injection is a critical antibiotic in veterinary medicine, designed to combat a wide range of bacterial infections in livestock. As a broad-spectrum bactericidal agent, it is particularly effective against both Gram-positive and Gram-negative bacteria. This article provides an in-depth analysis of its pharmacokinetic properties, adverse reactions, technical specifications, and applications, along with insights into the company behind this product, Shijiazhuang Shimu Pharmaceutical Co., Ltd..

Product Overview

Amoxicillin Injection is a semisynthetic penicillin derived from ampicillin, known for its efficacy in treating bacterial infections. It is specifically formulated for use in veterinary settings, targeting pathogens such as Mannheimia haemolytica and Pasteurella multocida in cattle and pigs. The product is available in a 100ml bottle, with a shelf life of 3 years, ensuring long-term usability for livestock producers.

The active ingredient, amoxicillin, works by inhibiting bacterial cell wall synthesis, a mechanism that makes it highly effective against a broad spectrum of pathogens. Its time-dependent action requires consistent dosing to maintain therapeutic levels in the bloodstream.

Pharmacokinetic Properties

Understanding the pharmacokinetics of Amoxicillin Injection is essential for optimal therapeutic outcomes. Here are the key details:

• Cmax (Maximum Plasma Concentration): In cattle, Cmax reaches 3.45 µg/ml 2.45 hours post-intramuscular administration. In pigs, it achieves 3.54 µg/ml within 2 hours.
• Distribution: Amoxicillin distributes primarily to the extracellular compartment, with low plasma protein binding (17%). It effectively reaches tissues such as the lungs, pleura, and bronchial tissues, matching plasma concentrations.
• Metabolism: The drug is metabolized in the liver via hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20% of the original compound).
• Excretion: The majority of amoxicillin is excreted via the kidneys, with secondary excretion through the biliary route and milk.

These properties ensure rapid onset of action and sustained efficacy, making it suitable for treating acute infections in livestock.

Adverse Reactions and Warnings

While Amoxicillin Injection is generally well-tolerated, it is important to be aware of potential adverse effects:

• Hypersensitivity Reactions: As with all penicillins, allergic reactions (e.g., anaphylaxis) may occur. It should not be administered to animals with a known allergy to β-lactams.
• Local Reactions: Transient injection site reactions, such as swelling or redness, may occur but typically resolve without intervention.
• Milk Withdrawal Period: Milk for human consumption must not be used during treatment. For cattle, the withdrawal period is 96 hours post-last dose, while the milk withdrawal period is 4 hours.

Always follow the product instructions for safe and effective use.

Technical Specifications

Applications in Veterinary Medicine

Amoxicillin Injection is widely used in veterinary practice to address bacterial infections in livestock. Key applications include:

• Respiratory Infections: Effective against Mannheimia haemolytica and Pasteurella multocida, which are common causes of bovine and porcine respiratory diseases.
• Systemic Infections: Treats infections affecting multiple organs, such as sepsis and abscesses.
• Post-Operative Prophylaxis: Prevents bacterial infections following surgical procedures in animals.

Its broad-spectrum activity and favorable pharmacokinetic profile make it a preferred choice for veterinarians managing livestock health.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reputable manufacturer of veterinary pharmaceuticals, dedicated to producing high-quality antibiotics and medications. With a focus on innovation and compliance with international standards, the company ensures that its products meet the rigorous demands of modern veterinary care. Their commitment to quality is reflected in the meticulous formulation of Amoxicillin Injection, which adheres to strict regulatory guidelines.

For more information about the company's mission and product range, visit their official website.

Conclusion

Amoxicillin Injection is a vital tool in the treatment of bacterial infections in veterinary medicine. Its broad-spectrum activity, favorable pharmacokinetic properties, and established safety profile make it an essential medication for livestock health. By adhering to proper dosing and withdrawal guidelines, veterinarians and producers can ensure effective treatment while maintaining the safety of the food supply. Shijiazhuang Shimu Pharmaceutical Co., Ltd. continues to play a critical role in advancing veterinary care through its commitment to quality and innovation.

References

National Institute of Standards and Technology (NIST) provides foundational research and standards that support the development of pharmaceuticals, including antibiotics. While this article focuses on veterinary applications, NIST's work in metrology and measurement science underpins the accuracy and reliability of drug formulations. For further information on NIST's contributions to scientific standards, visit their official website.