Amoxicillin Injection for Veterinary Use - Shijiazhuang Shimu Pharmaceutical Co., Ltd.|Broad-Spectrum Antibiotic, Respiratory Infection Treatment

Introduction

Amoxicillin Injection is a broad-spectrum antibiotic widely used in veterinary medicine to treat bacterial infections in livestock such as cattle and pigs. This article provides an in-depth analysis of its pharmacokinetic properties, technical specifications, applications, and the company behind the product, Shijiazhuang Shimu Pharmaceutical Co., Ltd.. The information is structured to highlight the product's efficacy, safety, and compliance with industry standards.

Product Overview

Amoxicillin Injection is a semisynthetic penicillin belonging to the amino-penicillin family. It is designed to combat both Gram-positive and Gram-negative bacteria, making it a versatile choice for treating respiratory infections in animals. The product is formulated to ensure rapid absorption and effective distribution in the body, with a focus on minimizing adverse reactions and adhering to strict withdrawal period guidelines.

Pharmacokinetic Properties

Understanding the pharmacokinetics of Amoxicillin Injection is critical for its effective use in veterinary medicine. Here’s a detailed breakdown of its behavior in the body:

• Peak Concentration (Cmax): In cattle, Cmax reaches 3.45 µg/ml within 2.45 hours after intramuscular administration. In pigs, the peak concentration is slightly higher at 3.54 µg/ml, achieved within 2 hours.
• Distribution: Amoxicillin is primarily distributed in the extracellular compartment. Its low plasma protein binding (17%) allows it to penetrate tissues effectively, including pulmonary, pleural, bronchial, and synovial tissues. It also diffuses into lymphatic tissue and fluids.
• Metabolism: The drug is metabolized in the liver via hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20% of the original compound).
• Excretion: The majority of Amoxicillin is excreted unchanged via the kidneys, with secondary excretion through the biliary route and milk.

Technical Specifications

Applications in Veterinary Medicine

Amoxicillin Injection is specifically indicated for treating respiratory infections in cattle and pigs. It targets pathogens such as Mannheimia haemolytica and Pasteurella multocida, which are common causes of bovine and porcine respiratory diseases. Its efficacy is further supported by its ability to maintain therapeutic concentrations in critical tissues and fluids, ensuring rapid bacterial clearance.

Key Applications:

• Respiratory tract infections in cattle and pigs.
• Management of bacterial infections where Gram-positive and Gram-negative bacteria are involved.
• Supportive treatment in cases of mixed bacterial infections.

For detailed information on amoxicillin injection uses, refer to the product’s official documentation.

Advantages of Amoxicillin Injection

The product offers several advantages that make it a preferred choice in veterinary medicine:

• Fast Onset of Action: Rapid absorption and distribution ensure quick therapeutic effects.
• Wide Spectrum of Activity: Effective against both Gram-positive and Gram-negative bacteria.
• Low Risk of Cross-Resistance: Amoxicillin’s structural relationship to ampicillin reduces the likelihood of resistance in many bacterial strains.
• Compliance with Safety Standards: Adheres to strict withdrawal period guidelines to ensure food safety.

Safety and Adverse Reactions

While Amoxicillin Injection is generally well-tolerated, it is essential to be aware of potential adverse reactions:

• Hypersensitivity Reactions: As with all penicillins, it may cause allergic reactions. It should not be used in animals with a known allergy to β-lactam antibiotics.
• Local Reactions: Transient injection site reactions may occur but are typically mild.
• Withdrawal Periods: Adherence to the specified withdrawal periods (28 days for meat, 4 hours for milk) is crucial to prevent residues in food products.

Veterinary amoxicillin injection should be administered under the guidance of a licensed veterinarian to minimize risks.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reputable pharmaceutical company specializing in veterinary healthcare solutions. With a commitment to quality and innovation, the company develops products that meet global standards for efficacy and safety. Their focus on research and development ensures that their formulations, such as Amoxicillin Injection, are tailored to address the specific needs of livestock health.

For more information about the company’s amoxicillin injection 1g and other products, visit their official website.

References

1. National Institute of Standards and Technology (NIST). NIST plays a critical role in developing measurement standards that underpin the accuracy and reliability of pharmaceutical products. While the specific page for this product is not accessible, NIST’s guidelines on drug testing and quality assurance are foundational to the industry. Source: https://www.nist.gov

2. Amoxicillin Injection Product Page. Shijiazhuang Shimu Pharmaceutical Co., Ltd. Retrieved from https://www.skyvetpharm.com/amoxicillin-injection.html.