Amoxicillin Injection-Veterinary Use|Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Amoxicillin Injection, produced by Shijiazhuang Shimu Pharmaceutical Co., Ltd., is a critical veterinary medication designed to combat bacterial infections in livestock. This article provides an in-depth analysis of its pharmacokinetic properties, applications, safety profile, and the company's commitment to quality. Whether you're a veterinarian, farmer, or pharmaceutical professional, this guide will help you understand the full potential of this antibiotic.

Product Overview

Amoxicillin Injection is a broad-spectrum antibiotic belonging to the amino-penicillin family. It is specifically formulated for veterinary use to treat infections caused by both Gram-positive and Gram-negative bacteria. The product is available in a 100ml bottle with a shelf life of 3 years, ensuring long-term storage and usability for agricultural and livestock management.

Key specifications include:

• Composition: Each milliliter contains 150mg of Amoxicillin.
• Packaging: 100ml/bottle.
• Storage: Seal and protect from light. Keep out of reach of children.
• Withdrawal Period: 28 days for cattle and pigs; 4 hours for milk.

Pharmacokinetic Properties

Understanding the pharmacokinetics of Amoxicillin Injection is essential for optimizing its therapeutic efficacy. The drug exhibits distinct absorption, distribution, metabolism, and excretion profiles in different animal species.

Absorption and Distribution

Following intramuscular administration, Amoxicillin reaches peak plasma concentrations (Cmax) at different intervals for cattle and pigs:

• Cattle: Cmax of 3.45 µg/ml is achieved 2.45 hours post-administration.
• Pigs: Cmax of 3.54 µg/ml is reached 2 hours after injection.

Amoxicillin is predominantly distributed in the extracellular compartment due to its low plasma protein binding (17%). It effectively accumulates in pulmonary, pleural, and bronchial tissues, matching plasma concentrations. The drug also diffuses into pleural and synovial fluids, as well as lymphatic tissue, ensuring broad coverage against respiratory pathogens.

Metabolism and Excretion

Metabolism occurs primarily in the liver through hydrolysis of the β-lactam ring, yielding inactive penicilloic acid (20% of the administered dose). The majority of the drug is excreted unchanged via the kidneys, with secondary excretion through the biliary route and milk. This renal excretion pathway highlights the importance of monitoring kidney function in animals with compromised renal health.

Applications in Veterinary Medicine

Amoxicillin Injection is a cornerstone in treating bacterial infections in livestock, particularly those caused by Mannheimia haemolytica and Pasteurella multocida. These pathogens are commonly associated with respiratory diseases in cattle and pigs, making the drug a vital tool in herd health management.

Target Pathogens

• Cattle: Effective against Mannheimia haemolytica and Pasteurella multocida in respiratory infections.
• Pigs: Active against Pasteurella multocida causing respiratory diseases.

Its broad-spectrum activity extends to other Gram-positive and Gram-negative bacteria, making it a versatile choice for managing diverse infections. The drug's time-dependent mechanism of action ensures sustained efficacy, particularly in cases requiring prolonged treatment.

Safety and Usage Guidelines

While Amoxicillin Injection is generally safe, adherence to usage guidelines is critical to minimize adverse effects and ensure compliance with regulatory standards.

Adverse Reactions

As with all penicillins, hypersensitivity (allergic) reactions may occur. It should not be administered to animals with known allergies to β-lactams. Local reactions at the injection site, though transient, may occasionally occur. Veterinary professionals should monitor animals closely for any signs of adverse effects.

Special Warnings

• Shake well before use to ensure proper suspension.
• Milk for human consumption: Must not be used during treatment. It can be safely harvested 96 hours post-last dose.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reputable manufacturer of veterinary pharmaceuticals, dedicated to producing high-quality antibiotics and animal health solutions. With a focus on innovation and compliance, the company ensures its products meet stringent regulatory standards.

As a leader in the veterinary pharmaceutical industry, Shijiazhuang Shimu Pharmaceutical Co., Ltd. prioritizes research and development to address evolving challenges in animal health. Their commitment to quality is reflected in the rigorous testing and production protocols applied to products like Amoxicillin Injection.

Product Specifications Table

Parameter	Details
Active Ingredient	Amoxicillin
Concentration	150mg/ml
Formulation	Injectable solution
Packaging	100ml/bottle
Shelf Life	3 years
Withdrawal Period (Cattle/Pigs)	28 days
Withdrawal Period (Milk)	4 hours

Conclusion

Amoxicillin Injection by Shijiazhuang Shimu Pharmaceutical Co., Ltd. is an essential tool in veterinary medicine, offering effective treatment for bacterial infections in livestock. Its robust pharmacokinetic profile, broad-spectrum activity, and adherence to safety standards make it a trusted choice for animal health professionals. By understanding its applications and proper usage, veterinarians and farmers can optimize outcomes while ensuring compliance with regulatory requirements.

References

1. National Institute of Standards and Technology (NIST). (n.d.). Standards and Measurements. Retrieved from https://www.nist.gov.

2. Shijiazhuang Shimu Pharmaceutical Co., Ltd. (n.d.). Amoxicillin Injection. Retrieved from https://www.skyvetpharm.com/amoxicillin-injection.html.