Amoxicillin Injection for Veterinary Use | Broad-Spectrum Antibiotic & Infection Treatment

Introduction to Amoxicillin Injection

Amoxicillin injection is a broad-spectrum antibiotic derived from the amino-penicillin family, closely related to ampicillin. It is a bactericidal agent effective against both Gram-positive and Gram-negative bacteria. This medication is widely used in veterinary medicine to treat infections caused by pathogens such as Mannheimia haemolytica and Pasteurella multocida, which are commonly associated with respiratory diseases in cattle and pigs.

Pharmacokinetic Properties

Understanding the pharmacokinetics of amoxicillin is critical for its effective use in veterinary applications. After intramuscular administration, the drug reaches peak plasma concentrations (Cmax) in different species:

• Cattle: Cmax of 3.45 µg/ml is achieved 2.45 hours post-administration.
• Pigs: Cmax of 3.54 µg/ml is reached 2 hours after injection.

Amoxicillin exhibits a low plasma protein binding rate (17%), allowing it to distribute effectively into extracellular compartments. It achieves therapeutic concentrations in tissues such as the lungs, pleura, and bronchial tissues, as well as in pleural, synovial, and lymphatic fluids. However, its biotransformation in the liver via hydrolysis of the β-lactam ring results in the formation of inactive penicilloic acid (20%).

The primary route of excretion is through the kidneys, with a secondary pathway via the biliary system and milk. This distribution profile underscores its suitability for treating infections in livestock and aquatic animals.

Key Features and Advantages

Amoxicillin injection offers several advantages that make it a preferred choice in veterinary medicine:

• Time-dependent antibiotic activity: Its efficacy is maximized when maintaining therapeutic concentrations over time.
• Targeted against respiratory pathogens: Effective against Mannheimia haemolytica and Pasteurella multocida, which are major causes of bovine and porcine respiratory diseases.
• Low protein binding: Facilitates rapid tissue penetration and ensures consistent drug levels in target areas.

Adverse Reactions and Precautions

Like all β-lactam antibiotics, amoxicillin carries a risk of hypersensitivity reactions. It should not be administered to animals with a known allergy to penicillins. While rare, local reactions at the injection site may occur but are typically transient.

Important warnings:

• Shake well before use to ensure uniform suspension.
• Milk for human consumption must be withheld during treatment. For cattle, milk can be safely used only after 96 hours post-treatment.

Withdrawal Periods

Adherence to withdrawal periods is essential to ensure food safety:

Species	Withdrawal Period
Cattle and Pigs	28 days
Milk	4 hours

Storage and Packaging

Amoxicillin injection should be stored in a sealed container111, protected from light, and kept out of reach of children. The product is available in a 100ml/bottle packaging, with a shelf life of 3 years under proper storage conditions.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Manufactured by Shijiazhuang Shimu Pharmaceutical Co., Ltd., a leading pharmaceutical company in China, Amoxicillin Injection exemplifies the company's commitment to quality and innovation in veterinary medicine. With a focus on veterinary antibiotics and animal health solutions, Shijiazhuang Shimu has established itself as a trusted provider of veterinary amoxicillin injection and other critical medications.

Technical Specifications

Parameter	Details
Active Ingredient	Amoxicillin 150mg/ml
Indication	Treatment of infections caused by Gram-positive and Gram-negative bacteria
Administration Route	Intramuscular
Withdrawal Period (Cattle/Pigs)	28 days
Withdrawal Period (Milk)	4 hours
Storage Conditions	Sealed, protected from light, out of reach of children
Shelf Life	3 years

Conclusion

Amoxicillin Injection is a vital tool in the treatment of bacterial infections in livestock, offering a combination of broad-spectrum activity, favorable pharmacokinetics, and minimal adverse effects. Its use is supported by the expertise of Shijiazhuang Shimu Pharmaceutical Co., Ltd., a company dedicated to advancing veterinary medicine through high-quality pharmaceutical products.

References

Information on the pharmacological properties of amoxicillin was referenced from National Institute of Standards and Technology (NIST), a trusted source for scientific and technical data.