Amoxicillin Injection-Veterinary Uses|Shijiazhuang Shimu Pharma

Amoxicillin Injection is a vital pharmaceutical solution designed for the treatment of bacterial infections in livestock, particularly in cattle and pigs. This amoxicillin injection belongs to the amino-penicillin family and is renowned for its broad-spectrum antibacterial activity. Manufactured by Shijiazhuang Shimu Pharmaceutical Co., Ltd., the product adheres to rigorous quality standards, ensuring efficacy and safety for veterinary use.

Pharmacokinetic Properties

Amoxicillin is a time-dependent antibiotic, meaning its effectiveness is closely tied to the duration of bacterial exposure rather than peak concentration. It exerts its bactericidal effect by inhibiting the synthesis and repair of bacterial cell walls, targeting both Gram-positive and Gram-negative bacteria. Notably, it is structurally similar to ampicillin but is susceptible to β-lactamase enzymes, which can inactivate its activity in certain bacterial strains.

Key Pharmacokinetic Data

• Cattle: Peak plasma concentration (Cmax) of 3.45 µg/ml is achieved 2.45 hours post-intramuscular administration.
• Pigs: Cmax of 3.54 µg/ml is reached 2 hours after intramuscular injection.
• Distribution: Amoxicillin distributes primarily to the extracellular compartment, with low plasma protein binding (17%). It accumulates in pulmonary, pleural, and bronchial tissues, as well as pleural and synovial fluids.
• Metabolism: The liver metabolizes amoxicillin via hydrolysis of the β-lactam ring, producing inactive penicilloic acid (20% of the drug).
• Excretion: The majority is excreted via the kidneys, with secondary elimination through the biliary route and milk.

Advantages of Amoxicillin Injection

Amoxicillin Injection offers several advantages, making it a preferred choice for veterinarians:

• Broad-Spectrum Activity: Effective against a wide range of pathogens, including Mannheimia haemolytica and Pasteurella multocida, which are common in respiratory infections in cattle and pigs.
• Quick Onset of Action: Rapid absorption and distribution ensure prompt therapeutic effects.
• Flexibility in Administration: Available in a 100ml bottle, it is suitable for large-scale livestock management.
• Cost-Effective: Provides a balance between efficacy and affordability, ideal for veterinary practices.

Technical Specifications

Parameter	Details
Active Ingredient	Amoxicillin 150mg/ml
Indications	Treatment of bacterial infections caused by Gram-positive and Gram-negative organisms.
Withdrawal Period	Cattle and pigs: 28 days; Milk: 4 hours.
Storage Conditions	Seal tightly, protect from light, and keep out of reach of children.
Shelf Life	3 years
Packaging	100ml/bottle

Applications in Veterinary Medicine

Amoxicillin Injection is widely used in veterinary settings to address bacterial infections in livestock. Its efficacy against Mannheimia haemolytica and Pasteurella multocida makes it a critical tool in managing respiratory diseases in cattle and pigs. The product is also suitable for treating skin, soft tissue, and urinary tract infections caused by susceptible organisms.

Due to its favorable pharmacokinetic profile, Amoxicillin Injection is particularly effective in targeting pathogens in extracellular spaces, such as in the lungs and joints. This makes it ideal for conditions like pneumonia, arthritis, and mastitis. The low plasma protein binding ensures that therapeutic concentrations are maintained in tissues, enhancing its antibacterial activity.

Important Considerations

Adverse Reactions and Warnings

• Hypersensitivity: As with all penicillins, amoxicillin may cause allergic reactions. It should not be administered to animals with a known allergy to β-lactams.
• Local Reactions: Transient injection site reactions may occur but are typically mild.
• Milk Safety: Milk from treated animals must not be used for human consumption during treatment. For cattle, a 96-hour withdrawal period is required before milk can be safely consumed.

Compliance with Regulatory Standards

Shijiazhuang Shimu Pharmaceutical Co., Ltd. ensures that Amoxicillin Injection meets international pharmaceutical standards. The company's commitment to quality is reflected in its adherence to guidelines set by regulatory bodies, including those outlined by the National Institute of Standards and Technology (NIST). While specific NIST references for this product are not directly accessible, NIST's role in establishing metrological standards for pharmaceuticals underscores the importance of precision and reliability in drug manufacturing (NIST, 2025).

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Based in Shijiazhuang, China, Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals. The company specializes in developing cost-effective, high-quality solutions for animal health, with a focus on antibiotics and antimicrobial agents. Its products are distributed globally, serving the needs of veterinarians and livestock producers.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. emphasizes research and development to ensure its products meet evolving industry requirements. The company's facilities are equipped with advanced technology to maintain strict quality control, ensuring that each batch of Amoxicillin Injection is safe, effective, and consistent.

Conclusion

Amoxicillin Injection is an essential tool in veterinary medicine, offering broad-spectrum antibacterial activity, rapid onset of action, and a favorable safety profile. Its pharmacokinetic properties make it ideal for treating respiratory and other bacterial infections in cattle and pigs. Manufactured by Shijiazhuang Shimu Pharmaceutical Co., Ltd., the product exemplifies the balance between efficacy, affordability, and compliance with global standards.

For more information on amoxicillin injection or to explore other veterinary pharmaceutical solutions, visit Shijiazhuang Shimu Pharmaceutical Co., Ltd.'s official website.

References

NIST. (2025). National Institute of Standards and Technology. Retrieved from https://www.nist.gov/

Shijiazhuang Shimu Pharmaceutical Co., Ltd. (n.d.). Amoxicillin Injection. Retrieved from https://www.skyvetpharm.com/amoxicillin-injection.html