Amoxicillin Injection for Veterinary Use | Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Amoxicillin Injection is a critical veterinary medication designed to combat bacterial infections in livestock. As a broad-spectrum antibiotic, it plays a vital role in maintaining the health of cattle and pigs. This article provides an in-depth analysis of its pharmacokinetic properties, applications, safety profile, and the company behind its production, Shijiazhuang Shimu Pharmaceutical Co., Ltd..

Product Overview

Amoxicillin Injection is a semisynthetic penicillin with potent bactericidal activity against both Gram-positive and Gram-negative bacteria. It is specifically formulated for veterinary use, targeting respiratory infections in cattle and pigs. The product is available in a 100ml bottle with a shelf life of 3 years, ensuring long-term storage and usability.

Read More About amoxicillin injection uses

Pharmacokinetic Properties

Understanding the pharmacokinetics of Amoxicillin Injection is essential for optimizing its therapeutic efficacy. Here’s a detailed breakdown:

Peak Concentration (Cmax)

• Cattle: Cmax of 3.45 µg/ml is achieved 2.45 hours after intramuscular administration.
• Pigs: Cmax of 3.54 µg/ml is reached 2 hours post-administration.

Distribution and Metabolism

Amoxicillin is primarily distributed in the extracellular compartment, with a low plasma protein binding rate of 17%. It effectively reaches pulmonary, pleural, and bronchial tissues, as well as pleural and synovial fluids. The drug is metabolized in the liver via hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20%).

Excretion

Approximately 70% of Amoxicillin is excreted via the kidneys in its active form. Secondary excretion routes include the biliary tract and milk, highlighting the importance of withdrawal periods for dairy animals.

Key Applications and Indications

Amoxicillin Injection is specifically indicated for treating bacterial infections caused by Mannheimia haemolytica and Pasteurella multocida in cattle and pigs. These pathogens are commonly associated with respiratory diseases, making the medication a cornerstone in veterinary medicine. Its time-dependent mechanism of action ensures sustained bacterial suppression, reducing the risk of resistance development.

Safety Profile and Adverse Reactions

While generally well-tolerated, Amoxicillin Injection requires careful administration to mitigate risks:

• Hypersensitivity: As with all β-lactam antibiotics, it may cause allergic reactions. It should not be used in animals with a known allergy to penicillins.
• Local Reactions: Transient injection site reactions may occur but are typically mild.
• Withdrawal Periods:
  • Cattle and Pigs: 28 days
  • Milk: 4 hours

Storage and Handling

Proper storage is critical to maintaining the drug's efficacy:

• Storage Conditions: Keep sealed and protected from light. Store at 20-25°C (68-77°F).
• Precautions: Keep out of reach of children. Shake well before use to ensure uniform suspension.

Product Specifications

Parameter	Details
Active Ingredient	Amoxicillin 150mg/ml
Formulation	Injectable Solution
Packaging	100ml/bottle
Shelf Life	3 years
Withdrawal Period	28 days (cattle/pigs), 4 hours (milk)

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals, dedicated to producing high-quality antibiotics and treatments. The company adheres to stringent quality control standards to ensure the safety and efficacy of its products. With a focus on innovation and compliance, Shimu Pharmaceutical has established itself as a trusted name in the veterinary industry.

Scientific Validation and Industry Standards

The development and use of antibiotics like Amoxicillin Injection are guided by rigorous scientific standards. According to the National Institute of Standards and Technology (NIST), accurate measurements and standardized protocols are critical for pharmaceutical efficacy and safety. NIST’s research on antimicrobial resistance and drug formulation ensures that products like Amoxicillin meet global benchmarks for quality and reliability.

Conclusion

Amoxicillin Injection is an essential tool in veterinary medicine, offering a reliable solution for bacterial infections in livestock. Its broad-spectrum activity, favorable pharmacokinetics, and adherence to safety guidelines make it a preferred choice for veterinarians. By leveraging the expertise of Shijiazhuang Shimu Pharmaceutical Co., Ltd., the product exemplifies the intersection of scientific innovation and practical application in animal health.

References

NIST (National Institute of Standards and Technology). (n.d.). Standards and Measurements. Retrieved from https://www.nist.gov.

Shijiazhuang Shimu Pharmaceutical Co., Ltd.. (n.d.). Amoxicillin Injection. Retrieved from https://www.skyvetpharm.com/amoxicillin-injection.html.