Amoxicillin Injection - Shijiazhuang Shimu Pharmaceutical|Pharmacokinetics&Veterinary Applications

Amoxicillin Injection is a critical pharmaceutical solution designed for the treatment of bacterial infections in livestock, including cattle and pigs. As a broad-spectrum antibiotic, it plays a vital role in veterinary medicine by targeting both Gram-positive and Gram-negative bacteria. This article provides an in-depth analysis of its pharmacokinetic properties, advantages, technical specifications, and applications, while also exploring the background of its manufacturer, Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Product Overview

Amoxicillin Injection is a semisynthetic penicillin with a chemical structure closely related to ampicillin. It functions as a bactericidal agent, inhibiting the synthesis and repair of bacterial cell walls by targeting the mucopeptide layer. This mechanism makes it highly effective against a wide range of pathogens, including Mannheimia haemolytica and Pasteurella multocida, which are commonly associated with respiratory diseases in cattle and pigs. The product is available in a 150mg/ml concentration, with a 100ml bottle packaging, ensuring ease of administration and storage.

Pharmacokinetic Properties

Understanding the pharmacokinetics of Amoxicillin Injection is essential for optimizing its therapeutic efficacy. Upon intramuscular administration, the drug reaches peak plasma concentrations (Cmax) within 2 to 2.45 hours in cattle and pigs. Its low plasma protein binding (17%) facilitates widespread distribution, with concentrations in tissues such as the lungs, pleura, and bronchial tissues closely matching plasma levels. This distribution pattern ensures effective targeting of respiratory pathogens.

Amoxicillin is primarily metabolized in the liver through hydrolysis of the β-lactam ring, forming inactive penicilloic acid. The majority of the drug is excreted via the kidneys in its active form, with secondary excretion through the biliary route and milk. These properties highlight its suitability for use in livestock, where rapid elimination and minimal accumulation are critical for safety and compliance with withdrawal periods.

Key Advantages of Amoxicillin Injection

Amoxicillin Injection offers several advantages that make it a preferred choice in veterinary medicine:

• Wide Spectrum of Activity: Effective against both Gram-positive and Gram-negative bacteria, including common respiratory pathogens in cattle and pigs.
• Time-Dependent Efficacy: Its bactericidal action is optimized with consistent drug concentrations over time, ensuring sustained therapeutic effects.
• Low Toxicity: Minimal adverse effects when used as directed, with only occasional local reactions at the injection site.
• Convenient Administration: Available in a 100ml bottle, allowing for easy dosing and storage.

Technical Specifications

Parameter	Details
Active Ingredient	Amoxicillin (150mg/ml)
Administration Route	Intramuscular
Peak Plasma Concentration (Cmax)	Cattle: 3.45 µg/ml (2.45 hours post-administration) Pigs: 3.54 µg/ml (2 hours post-administration)
Plasma Protein Binding	17%
Metabolism	Hydrolysis in the liver to penicilloic acid
Excretion	Primarily via kidneys; secondary via biliary and milk routes
Withdrawal Period	Cattle and Pigs: 28 days Milk: 4 hours
Storage Conditions	Sealed, protected from light, and kept out of children's reach
Shelf Life	3 years

Applications in Veterinary Medicine

Amoxicillin Injection is widely used in the treatment of bacterial infections in livestock, particularly those affecting the respiratory system. Its efficacy against Mannheimia haemolytica and Pasteurella multocida makes it a cornerstone in managing respiratory diseases in cattle and pigs. The drug's ability to achieve therapeutic concentrations in key tissues, such as the lungs and pleura, ensures targeted action against these pathogens.

Additionally, Amoxicillin Injection is employed in the prevention and treatment of infections caused by Gram-positive and Gram-negative bacteria in various veterinary settings. Its low toxicity profile and favorable pharmacokinetic properties make it a reliable option for large-scale animal health management.

Adverse Reactions and Safety Considerations

As with all penicillins, Amoxicillin Injection may cause hypersensitivity reactions in animals allergic to β-lactams. While rare, these reactions can range from mild local irritation at the injection site to more severe systemic responses. It is crucial to avoid use in animals with a known allergy to penicillin derivatives.

Special precautions include shaking the solution well before use to ensure homogeneity. Furthermore, milk from treated animals should not be used for human consumption during the withdrawal period, which is 4 hours for milk and 28 days for meat. These measures ensure compliance with food safety regulations and minimize the risk of residual drug contamination.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd., based in China, is a reputable manufacturer of veterinary pharmaceuticals, including Amoxicillin Injection. The company adheres to stringent quality control standards to ensure the safety and efficacy of its products. With a focus on innovation and compliance, Shimu Pharmaceutical has established itself as a trusted provider in the veterinary healthcare sector.

For more information about the company's products and services, visit Shijiazhuang Shimu Pharmaceutical Co., Ltd..

Conclusion

Amoxicillin Injection is an indispensable tool in veterinary medicine, offering a reliable solution for combating bacterial infections in livestock. Its broad-spectrum activity, favorable pharmacokinetic profile, and ease of use make it a preferred choice for veterinarians and livestock producers. By adhering to proper administration guidelines and withdrawal periods, stakeholders can ensure the safety of both animals and consumers.

References

National Institute of Standards and Technology (NIST) plays a critical role in advancing measurement science, which underpins the development of pharmaceutical standards. While NIST's primary focus is on technological innovation, its work in metrology and standards ensures the accuracy and reliability of medical products, including antibiotics like Amoxicillin Injection.

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