Amoxicillin Injection for Veterinary Use | Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Amoxicillin injection is a critical medication in veterinary medicine, designed to combat a wide range of bacterial infections in livestock. Developed by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this antibiotic belongs to the amino-penicillin family and is renowned for its efficacy against both Gram-positive and Gram-negative bacteria. This article provides an in-depth analysis of its pharmacokinetic properties, applications, and technical specifications, supported by authoritative references and product imagery.

Product Overview

Amoxicillin injection is a semisynthetic penicillin antibiotic that works by inhibiting bacterial cell wall synthesis. Its broad-spectrum activity makes it a preferred choice for treating respiratory infections in cattle and pigs. The product is formulated to ensure rapid absorption and effective distribution throughout the body, with specific dosing guidelines tailored to different animal species.

Read More About amoxicillin injection uses

Key Features and Benefits

• Broad-Spectrum Activity: Effective against a wide range of bacteria, including Mannheimia haemolytica and Pasteurella multocida in cattle and pigs.
• Time-Dependent Efficacy: Amoxicillin's bactericidal action is optimized when maintained at therapeutic concentrations over time.
• Low Plasma Protein Binding: Ensures efficient distribution to target tissues, including respiratory and lymphatic systems.
• Short Withdrawal Period: 4 hours for milk and 28 days for meat, aligning with food safety standards.

Pharmacokinetic Properties

Understanding the pharmacokinetics of amoxicillin injection is essential for optimizing its therapeutic use. Here’s a detailed breakdown:

Administration and Absorption

After intramuscular administration, amoxicillin reaches peak plasma concentrations (Cmax) within 2 to 2.45 hours. In cattle, the Cmax is 3.45 µg/ml, while in pigs, it reaches 3.54 µg/ml. This rapid absorption ensures quick onset of action, making it ideal for acute infections.

Distribution and Metabolism

Amoxicillin distributes primarily to the extracellular compartment, with minimal plasma protein binding (17%). It achieves therapeutic concentrations in critical tissues such as the lungs, pleura, and bronchial tissues. The drug is metabolized in the liver via hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20% of the original compound).

Excretion

The primary route of excretion is through the kidneys, with secondary elimination via the biliary tract and milk. This makes it important to monitor withdrawal periods to ensure compliance with food safety regulations.

Technical Specifications

Parameter	Details
Active Ingredient	Amoxicillin 150mg/ml
Indications	Treatment of infections caused by Gram-positive and Gram-negative bacteria
Administration Route	Intramuscular
Withdrawal Period	Cattle and pigs: 28 days; Milk: 4 hours
Storage Conditions	Sealed, protected from light, and kept out of reach of children
Packaging	100ml/bottle
Shelf Life	3 years

Applications in Veterinary Medicine

Amoxicillin injection is widely used in veterinary practice for treating respiratory infections in livestock. Its efficacy against Mannheimia haemolytica and Pasteurella multocida makes it a cornerstone in managing bovine and porcine respiratory diseases. Additionally, it is effective in treating infections in other organs, such as the urinary tract and skin, where bacterial pathogens are prevalent.

Adverse Reactions and Precautions

While generally well-tolerated, amoxicillin injection may cause hypersensitivity reactions in animals with known allergies to β-lactams. Local reactions at the injection site, such as swelling or redness, are occasionally observed but typically resolve spontaneously. It is crucial to avoid using the drug in animals with a history of penicillin allergies.

Important Warnings:

• Shake the solution well before use.
• Do not use milk from treated animals for human consumption during the withdrawal period.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals, dedicated to producing high-quality antibiotics and other medicinal products. With a focus on innovation and compliance with international standards, the company ensures that its products meet the highest safety and efficacy criteria. Their commitment to research and development has made them a trusted name in the veterinary industry.

Conclusion

Amoxicillin injection remains a vital tool in the treatment of bacterial infections in livestock, offering a combination of broad-spectrum activity, favorable pharmacokinetics, and ease of administration. Its role in maintaining animal health and food safety underscores its importance in modern veterinary medicine. For more information, visit the Shijiazhuang Shimu Pharmaceutical Co., Ltd. website or explore the amoxicillin injection product page.

References

1. National Institute of Standards and Technology (NIST) - For authoritative guidelines on pharmaceutical standards and analytical methods.

2. Shijiazhuang Shimu Pharmaceutical Co., Ltd. - Manufacturer’s technical data and product specifications.