Amoxicillin Injection-Shijiazhuang Shimu Pharmaceutical Co., Ltd.|Veterinary Antibiotic & Broad-Spectrum Treatment

Amoxicillin Injection is a critical pharmaceutical solution designed for the treatment of bacterial infections in veterinary medicine. As a broad-spectrum antibiotic, it belongs to the amino-penicillin family, offering targeted efficacy against a wide range of pathogens. This article delves into the product's pharmacokinetic properties, applications, safety profile, and technical specifications, while also highlighting the company background of Shijiazhuang Shimu Pharmaceutical Co., Ltd. (石家庄石牧药业有限公司). For further details, visit the official product page: Amoxicillin Injection Page.

Product Overview

Amoxicillin Injection is a semisynthetic penicillin antibiotic formulated for intramuscular administration. It is specifically designed to combat infections caused by Gram-positive and Gram-negative bacteria, making it a versatile choice for veterinary applications. The product is available in a 100ml bottle, with a shelf life of 3 years when stored properly. Its primary use is in treating respiratory diseases in cattle and pigs, including infections caused by Mannheimia haemolytica and Pasteurella multocida.

Key features of the product include:

• Broad-spectrum activity against bacterial pathogens
• Time-dependent antibiotic action
• Rapid absorption following intramuscular injection
• Low plasma protein binding (17%), facilitating tissue distribution

Pharmacokinetic Properties

Understanding the pharmacokinetic profile of Amoxicillin Injection is essential for optimizing its therapeutic use. Here’s a detailed breakdown:

Absorption

After intramuscular administration, Amoxicillin reaches peak plasma concentrations (Cmax) within 2.45 hours in cattle and 2 hours in pigs. The Cmax values are 3.45 µg/ml in cattle and 3.54 µg/ml in pigs, indicating efficient systemic absorption.

Distribution

Amoxicillin is predominantly distributed in the extracellular compartment due to its low plasma protein binding. It achieves similar concentrations in pulmonary, pleural, and bronchial tissues as in plasma, enabling effective targeting of respiratory pathogens. The drug also diffuses into pleural, synovial, and lymphatic tissues, enhancing its therapeutic reach.

Metabolism

The liver metabolizes Amoxicillin through hydrolysis of the β-lactam ring, producing inactive penicilloic acid (20%). This metabolic pathway ensures the drug’s safety profile, as the metabolites are non-toxic.

Excretion

Amoxicillin is primarily excreted via the kidneys in its active form. Secondary routes include biliary excretion and milk secretion, which necessitates adherence to withdrawal periods to ensure food safety.

Applications in Veterinary Medicine

Amoxicillin Injection is widely used in livestock management to address bacterial infections. Its primary applications include:

• Respiratory infections in cattle and pigs caused by Mannheimia haemolytica and Pasteurella multocida
• Systemic bacterial infections requiring broad-spectrum coverage
• Preventive treatment in high-risk environments

The drug’s time-dependent mechanism ensures sustained antibacterial activity, making it suitable for conditions requiring prolonged therapeutic effects.

Safety and Adverse Reactions

While Amoxicillin Injection is generally safe, certain precautions must be observed:

• Hypersensitivity reactions: As with all beta-lactams, it may cause allergic reactions. It should not be administered to animals with known allergies to penicillins.
• Local reactions: Transient injection site reactions may occur but are typically mild.
• Milk withdrawal period: Milk from treated animals must not be used for human consumption during treatment. The withdrawal period is 4 hours for milk and 28 days for meat in cattle and pigs.

For detailed safety guidelines, refer to the product specifications.

Technical Specifications

Parameter	Details
Active Ingredient	Amoxicillin 150mg/ml
Formulation	Injectable solution
Administration Route	Intramuscular
Withdrawal Period	Cattle/Pigs: 28 days; Milk: 4 hours
Storage Conditions	Sealed, protected from light, and kept out of reach of children
Shelf Life	3 years

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. (石家庄石牧药业有限公司) is a leading manufacturer of veterinary pharmaceuticals, dedicated to developing high-quality antibiotics and treatments for livestock. With a focus on innovation and safety, the company ensures its products meet rigorous regulatory standards. Their commitment to animal health and food safety is reflected in the meticulous formulation of Amoxicillin Injection.

For more information about the company, visit their official website: Shijiazhuang Shimu Pharmaceutical Co., Ltd..

Conclusion

Amoxicillin Injection is a vital tool in veterinary medicine, offering effective treatment for bacterial infections while maintaining a favorable safety profile. Its pharmacokinetic advantages, broad-spectrum activity, and user-friendly formulation make it a preferred choice for livestock health management. As a product of Shijiazhuang Shimu Pharmaceutical Co., Ltd., it exemplifies the company’s dedication to quality and innovation in veterinary care.

References

1. National Institute of Standards and Technology (NIST) – For authoritative standards in pharmaceutical measurements and safety protocols.

2. Amoxicillin Injection Product Page – Detailed specifications and usage guidelines.

3. Shijiazhuang Shimu Pharmaceutical Co., Ltd. – Official company information and product portfolio.